Extraadrenal adrenaline formation by two separate enzymes

Adrenaline (A) is synthesized in the adrenal medullae by the enzyme phenylethanolamine-N-methyltransferase (PNMT). After surgical removal of the adrenal medullae tissue A levels ranged from 22% of control in the heart to 125% of control in the liver. Use of a novel assay to measure tissue A formatio...

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Veröffentlicht in:	Experientia 1989-08, Vol.45 (8), p.718-720
Hauptverfasser:	Ziegler, M G, Kennedy, B, Elayan, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - physiology Animals Catechol O-Methyltransferase - metabolism Deoxyepinephrine - metabolism Epinephrine - biosynthesis Hormones, Ectopic - biosynthesis Male Norepinephrine - metabolism Phenylethanolamine N-Methyltransferase - metabolism Rats Rats, Inbred Strains
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Beschreibung
Zusammenfassung:	Adrenaline (A) is synthesized in the adrenal medullae by the enzyme phenylethanolamine-N-methyltransferase (PNMT). After surgical removal of the adrenal medullae tissue A levels ranged from 22% of control in the heart to 125% of control in the liver. Use of a novel assay to measure tissue A formation revealed that many tissues can synthesize A using PNMT and another enzyme that N-methylates both noradrenaline and dopamine. These enzymes are non-neuronal, inducible and synthesize a major fraction of tissue and urine A.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01974566