The pharmacologic evaluation of locomotor activity versus inflammatory parameters in rat adjuvant arthritis
Adjuvant-induced arthritis (AA) is an experimental model of inflammatory joint disease in the rat which mimics rheumatoid arthritis. Although paw inflammation (e.g., swelling) is commonly used to monitor the efficacy of antiarthritic drugs, a reduction in locomotor function may provide a more sensit...
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| Veröffentlicht in: | Agents and Actions 1993-03, Vol.39 Spec No (S1), p.C201-C203 |
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| container_title | Agents and Actions |
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| creator | Selph, J L Boncek, V M Soroko, F E Harris, T M Cochran, F R |
| description | Adjuvant-induced arthritis (AA) is an experimental model of inflammatory joint disease in the rat which mimics rheumatoid arthritis. Although paw inflammation (e.g., swelling) is commonly used to monitor the efficacy of antiarthritic drugs, a reduction in locomotor function may provide a more sensitive evaluation of "functional disability" in AA rats. The purpose of the present study was to investigate the effect of dietary therapy with prednisolone or ibuprofen on locomotor activity as well as arthritic symptoms in established AA (days 20-42). AA rats demonstrated an increase in arthritis scores, spleen weights, fibrinogen, and WBC along with a reduction in locomotor function. Prednisolone (2 mg/kg/day) exhibited a positive therapeutic effect on all these parameters. Ibuprofen (50 mg/kg/day) consistently lowered arthritis scores and fibrinogen; however, locomotor function only improved on day 35. In conclusion, the measurement of locomotor activity in concert with other experimental parameters may provide a more meaningful evaluation of disease severity or improvement in AA. |
| doi_str_mv | 10.1007/BF01972766 |
| format | Article |
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Although paw inflammation (e.g., swelling) is commonly used to monitor the efficacy of antiarthritic drugs, a reduction in locomotor function may provide a more sensitive evaluation of "functional disability" in AA rats. The purpose of the present study was to investigate the effect of dietary therapy with prednisolone or ibuprofen on locomotor activity as well as arthritic symptoms in established AA (days 20-42). AA rats demonstrated an increase in arthritis scores, spleen weights, fibrinogen, and WBC along with a reduction in locomotor function. Prednisolone (2 mg/kg/day) exhibited a positive therapeutic effect on all these parameters. Ibuprofen (50 mg/kg/day) consistently lowered arthritis scores and fibrinogen; however, locomotor function only improved on day 35. In conclusion, the measurement of locomotor activity in concert with other experimental parameters may provide a more meaningful evaluation of disease severity or improvement in AA.</description><identifier>ISSN: 0065-4299</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/BF01972766</identifier><identifier>PMID: 8273568</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; Arthritis, Experimental - diet therapy ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - physiopathology ; Female ; Fibrinogen - metabolism ; Ibuprofen - therapeutic use ; Joints - physiopathology ; Leukocyte Count - drug effects ; Motor Activity - drug effects ; Organ Size - drug effects ; Prednisolone - therapeutic use ; Rats ; Rats, Inbred Lew ; Spleen - drug effects ; Spleen - pathology</subject><ispartof>Agents and Actions, 1993-03, Vol.39 Spec No (S1), p.C201-C203</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c197t-b07768751d42ef76de0c4658f3a5e6764b9aa96bef8def3f1401f9062806c5913</citedby><cites>FETCH-LOGICAL-c197t-b07768751d42ef76de0c4658f3a5e6764b9aa96bef8def3f1401f9062806c5913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8273568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selph, J L</creatorcontrib><creatorcontrib>Boncek, V M</creatorcontrib><creatorcontrib>Soroko, F E</creatorcontrib><creatorcontrib>Harris, T M</creatorcontrib><creatorcontrib>Cochran, F R</creatorcontrib><title>The pharmacologic evaluation of locomotor activity versus inflammatory parameters in rat adjuvant arthritis</title><title>Agents and Actions</title><addtitle>Agents Actions</addtitle><description>Adjuvant-induced arthritis (AA) is an experimental model of inflammatory joint disease in the rat which mimics rheumatoid arthritis. Although paw inflammation (e.g., swelling) is commonly used to monitor the efficacy of antiarthritic drugs, a reduction in locomotor function may provide a more sensitive evaluation of "functional disability" in AA rats. The purpose of the present study was to investigate the effect of dietary therapy with prednisolone or ibuprofen on locomotor activity as well as arthritic symptoms in established AA (days 20-42). AA rats demonstrated an increase in arthritis scores, spleen weights, fibrinogen, and WBC along with a reduction in locomotor function. Prednisolone (2 mg/kg/day) exhibited a positive therapeutic effect on all these parameters. Ibuprofen (50 mg/kg/day) consistently lowered arthritis scores and fibrinogen; however, locomotor function only improved on day 35. In conclusion, the measurement of locomotor activity in concert with other experimental parameters may provide a more meaningful evaluation of disease severity or improvement in AA.</description><subject>Animals</subject><subject>Arthritis, Experimental - diet therapy</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - physiopathology</subject><subject>Female</subject><subject>Fibrinogen - metabolism</subject><subject>Ibuprofen - therapeutic use</subject><subject>Joints - physiopathology</subject><subject>Leukocyte Count - drug effects</subject><subject>Motor Activity - drug effects</subject><subject>Organ Size - drug effects</subject><subject>Prednisolone - therapeutic use</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Spleen - drug effects</subject><subject>Spleen - pathology</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo67p68S7k5EGoJm3z0aMurgoLXlbwVqZp4kbbpiZpYf-9lV30NMO8Dy_Mg9AlJbeUEHH3sCK0EKng_AjNaZ6SpCDy_RjNCeEsydOiOEVnIXwSwhiVdIZmMhUZ43KOvjZbjfst-BaUa9yHVViP0AwQreuwM7hxyrUuOo9BRTvauMOj9mEI2HamgbaFKdvhHjy0Ok7JdMceIob6cxihmxYft95GG87RiYEm6IvDXKC31eNm-ZysX59elvfrRE1fxKQiQnApGK3zVBvBa01Uzpk0GTDNBc-rAqDglTay1iYzNCfUFISnknDFCpot0PW-t_fue9Ahlq0NSjcNdNoNoRScZmIqmsCbPai8C8FrU_betuB3JSXlr9ny3-wEXx1ah6rV9R96UJn9AC5RdaI</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Selph, J L</creator><creator>Boncek, V M</creator><creator>Soroko, F E</creator><creator>Harris, T M</creator><creator>Cochran, F R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>The pharmacologic evaluation of locomotor activity versus inflammatory parameters in rat adjuvant arthritis</title><author>Selph, J L ; Boncek, V M ; Soroko, F E ; Harris, T M ; Cochran, F R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c197t-b07768751d42ef76de0c4658f3a5e6764b9aa96bef8def3f1401f9062806c5913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arthritis, Experimental - diet therapy</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - physiopathology</topic><topic>Female</topic><topic>Fibrinogen - metabolism</topic><topic>Ibuprofen - therapeutic use</topic><topic>Joints - physiopathology</topic><topic>Leukocyte Count - drug effects</topic><topic>Motor Activity - drug effects</topic><topic>Organ Size - drug effects</topic><topic>Prednisolone - therapeutic use</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Spleen - drug effects</topic><topic>Spleen - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selph, J L</creatorcontrib><creatorcontrib>Boncek, V M</creatorcontrib><creatorcontrib>Soroko, F E</creatorcontrib><creatorcontrib>Harris, T M</creatorcontrib><creatorcontrib>Cochran, F R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selph, J L</au><au>Boncek, V M</au><au>Soroko, F E</au><au>Harris, T M</au><au>Cochran, F R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pharmacologic evaluation of locomotor activity versus inflammatory parameters in rat adjuvant arthritis</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1993-03</date><risdate>1993</risdate><volume>39 Spec No</volume><issue>S1</issue><spage>C201</spage><epage>C203</epage><pages>C201-C203</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>Adjuvant-induced arthritis (AA) is an experimental model of inflammatory joint disease in the rat which mimics rheumatoid arthritis. Although paw inflammation (e.g., swelling) is commonly used to monitor the efficacy of antiarthritic drugs, a reduction in locomotor function may provide a more sensitive evaluation of "functional disability" in AA rats. The purpose of the present study was to investigate the effect of dietary therapy with prednisolone or ibuprofen on locomotor activity as well as arthritic symptoms in established AA (days 20-42). AA rats demonstrated an increase in arthritis scores, spleen weights, fibrinogen, and WBC along with a reduction in locomotor function. Prednisolone (2 mg/kg/day) exhibited a positive therapeutic effect on all these parameters. Ibuprofen (50 mg/kg/day) consistently lowered arthritis scores and fibrinogen; however, locomotor function only improved on day 35. In conclusion, the measurement of locomotor activity in concert with other experimental parameters may provide a more meaningful evaluation of disease severity or improvement in AA.</abstract><cop>Switzerland</cop><pmid>8273568</pmid><doi>10.1007/BF01972766</doi></addata></record> |
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| ispartof | Agents and Actions, 1993-03, Vol.39 Spec No (S1), p.C201-C203 |
| issn | 0065-4299 1420-908X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Arthritis, Experimental - diet therapy Arthritis, Experimental - drug therapy Arthritis, Experimental - physiopathology Female Fibrinogen - metabolism Ibuprofen - therapeutic use Joints - physiopathology Leukocyte Count - drug effects Motor Activity - drug effects Organ Size - drug effects Prednisolone - therapeutic use Rats Rats, Inbred Lew Spleen - drug effects Spleen - pathology |
| title | The pharmacologic evaluation of locomotor activity versus inflammatory parameters in rat adjuvant arthritis |
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