Modification of adjuvant inflammation in rats deficient in essential fatty acids
Rats deficient in essential fatty acids (EFA) did not develop as much foot swelling on receiving injections of complete Freund's adjuvant as did normal controls. Both the acute inflammation and the chronic inflammation were affected. This reduction in the chronic phase of adjuvant inflammation...
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| Veröffentlicht in: | Agents and Actions 1976-09, Vol.6 (5), p.636-641 |
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| container_title | Agents and Actions |
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| creator | Denko, C W |
| description | Rats deficient in essential fatty acids (EFA) did not develop as much foot swelling on receiving injections of complete Freund's adjuvant as did normal controls. Both the acute inflammation and the chronic inflammation were affected. This reduction in the chronic phase of adjuvant inflammation was restored to normal levels by feeding a small supplement of corn oil as a dietary source of EFA. Since the EFA are biologic precursors of prostaglandins (PG), the lack of EFA is thought to influence adjuvant-induced inflammation by reducing available PG mediators of inflammation. |
| doi_str_mv | 10.1007/BF01971583 |
| format | Article |
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Both the acute inflammation and the chronic inflammation were affected. This reduction in the chronic phase of adjuvant inflammation was restored to normal levels by feeding a small supplement of corn oil as a dietary source of EFA. Since the EFA are biologic precursors of prostaglandins (PG), the lack of EFA is thought to influence adjuvant-induced inflammation by reducing available PG mediators of inflammation.</description><identifier>ISSN: 0065-4299</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/BF01971583</identifier><identifier>PMID: 970293</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Acute Disease ; Adrenal Glands - drug effects ; Animals ; Chronic Disease ; Fatty Acids, Essential - deficiency ; Inflammation - diet therapy ; Inflammation - etiology ; Male ; Oils - therapeutic use ; Organ Size - drug effects ; Prostaglandins - physiology ; Rats ; Spleen - drug effects ; Thymus Gland - drug effects ; Zea mays</subject><ispartof>Agents and Actions, 1976-09, Vol.6 (5), p.636-641</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-537a0f2ae888cbc1c9406b0e3f6d3a502c2db5dfc523c578b15e5c895ea800863</citedby><cites>FETCH-LOGICAL-c281t-537a0f2ae888cbc1c9406b0e3f6d3a502c2db5dfc523c578b15e5c895ea800863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/970293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Denko, C W</creatorcontrib><title>Modification of adjuvant inflammation in rats deficient in essential fatty acids</title><title>Agents and Actions</title><addtitle>Agents Actions</addtitle><description>Rats deficient in essential fatty acids (EFA) did not develop as much foot swelling on receiving injections of complete Freund's adjuvant as did normal controls. Both the acute inflammation and the chronic inflammation were affected. This reduction in the chronic phase of adjuvant inflammation was restored to normal levels by feeding a small supplement of corn oil as a dietary source of EFA. Since the EFA are biologic precursors of prostaglandins (PG), the lack of EFA is thought to influence adjuvant-induced inflammation by reducing available PG mediators of inflammation.</description><subject>Acute Disease</subject><subject>Adrenal Glands - drug effects</subject><subject>Animals</subject><subject>Chronic Disease</subject><subject>Fatty Acids, Essential - deficiency</subject><subject>Inflammation - diet therapy</subject><subject>Inflammation - etiology</subject><subject>Male</subject><subject>Oils - therapeutic use</subject><subject>Organ Size - drug effects</subject><subject>Prostaglandins - physiology</subject><subject>Rats</subject><subject>Spleen - drug effects</subject><subject>Thymus Gland - drug effects</subject><subject>Zea mays</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAUhYP4qqMb1y6yciFUb5JJmyx1cFQY0YWCu3KbB2ToY2xaYf691Q66OgfOx1l8hJwzuGYA-c3dEpjOmVRijyRsziHVoD72SQKQyXTOtT4mJzGuAaRkih2RQ50D1yIhr8-tDT4Y7EPb0NZTtOvhC5uehsZXWNfTEBraYR-pdSMb3O9MXYxjC1hRj32_pWiCjafkwGMV3dkuZ-R9ef-2eExXLw9Pi9tVarhifSpFjuA5OqWUKQ0zeg5ZCU74zAqUwA23pbTeSC6MzFXJpJNGaelQAahMzMjl9Lvp2s_Bxb6oQzSuqrBx7RALJaQUXMEIXk2g6doYO-eLTRdq7LYFg-LHXvFvb4Qvdq9DWTv7h066xDeKTWoi</recordid><startdate>197609</startdate><enddate>197609</enddate><creator>Denko, C W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197609</creationdate><title>Modification of adjuvant inflammation in rats deficient in essential fatty acids</title><author>Denko, C W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-537a0f2ae888cbc1c9406b0e3f6d3a502c2db5dfc523c578b15e5c895ea800863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Acute Disease</topic><topic>Adrenal Glands - drug effects</topic><topic>Animals</topic><topic>Chronic Disease</topic><topic>Fatty Acids, Essential - deficiency</topic><topic>Inflammation - diet therapy</topic><topic>Inflammation - etiology</topic><topic>Male</topic><topic>Oils - therapeutic use</topic><topic>Organ Size - drug effects</topic><topic>Prostaglandins - physiology</topic><topic>Rats</topic><topic>Spleen - drug effects</topic><topic>Thymus Gland - drug effects</topic><topic>Zea mays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Denko, C W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Denko, C W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of adjuvant inflammation in rats deficient in essential fatty acids</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1976-09</date><risdate>1976</risdate><volume>6</volume><issue>5</issue><spage>636</spage><epage>641</epage><pages>636-641</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>Rats deficient in essential fatty acids (EFA) did not develop as much foot swelling on receiving injections of complete Freund's adjuvant as did normal controls. 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| fulltext | fulltext |
| identifier | ISSN: 0065-4299 |
| ispartof | Agents and Actions, 1976-09, Vol.6 (5), p.636-641 |
| issn | 0065-4299 1420-908X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01971583 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Acute Disease Adrenal Glands - drug effects Animals Chronic Disease Fatty Acids, Essential - deficiency Inflammation - diet therapy Inflammation - etiology Male Oils - therapeutic use Organ Size - drug effects Prostaglandins - physiology Rats Spleen - drug effects Thymus Gland - drug effects Zea mays |
| title | Modification of adjuvant inflammation in rats deficient in essential fatty acids |
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