Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens

Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was...

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Veröffentlicht in:Agents and Actions 1977-07, Vol.7 (2), p.299-304
Hauptverfasser: Karakoz, I, Vosmik, F, Blaszczyk, B, Krejci, J, Pekarek, J, Hraba, T, Hala, K
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container_end_page 304
container_issue 2
container_start_page 299
container_title Agents and Actions
container_volume 7
creator Karakoz, I
Vosmik, F
Blaszczyk, B
Krejci, J
Pekarek, J
Hraba, T
Hala, K
description Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. Significant reduction of anti-HSA titres was found after 50 mg/animal doses of 6-mercaptopurine, colcemid (1 mg/KBW), 25 MG/KBW or cyclophosphamide and after the methotrexate treatment.
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In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. 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subjects animal diseases
animal health
Animals
Chickens
Comb and Wattles - pathology
Cyclophosphamide - pharmacology
Dactinomycin - pharmacology
Demecolcine - pharmacology
Hypersensitivity, Delayed - pathology
Hypersensitivity, Delayed - physiopathology
Immunization
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - toxicity
Mercaptopurine - pharmacology
Methotrexate - pharmacology
Tuberculin
title Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens
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