Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens
Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was...
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Veröffentlicht in: | Agents and Actions 1977-07, Vol.7 (2), p.299-304 |
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creator | Karakoz, I Vosmik, F Blaszczyk, B Krejci, J Pekarek, J Hraba, T Hala, K |
description | Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. Significant reduction of anti-HSA titres was found after 50 mg/animal doses of 6-mercaptopurine, colcemid (1 mg/KBW), 25 MG/KBW or cyclophosphamide and after the methotrexate treatment. |
doi_str_mv | 10.1007/BF01969988 |
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In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. Significant reduction of anti-HSA titres was found after 50 mg/animal doses of 6-mercaptopurine, colcemid (1 mg/KBW), 25 MG/KBW or cyclophosphamide and after the methotrexate treatment.</description><identifier>ISSN: 0065-4299</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/BF01969988</identifier><identifier>PMID: 899978</identifier><language>eng</language><publisher>Switzerland</publisher><subject>animal diseases ; animal health ; Animals ; Chickens ; Comb and Wattles - pathology ; Cyclophosphamide - pharmacology ; Dactinomycin - pharmacology ; Demecolcine - pharmacology ; Hypersensitivity, Delayed - pathology ; Hypersensitivity, Delayed - physiopathology ; Immunization ; Immunosuppressive Agents - pharmacology ; Immunosuppressive Agents - toxicity ; Mercaptopurine - pharmacology ; Methotrexate - pharmacology ; Tuberculin</subject><ispartof>Agents and Actions, 1977-07, Vol.7 (2), p.299-304</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c264t-6701f2725beefe25e00f67c63b74518740ee92e8bc0159e2d6a7dbb207d381983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/899978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karakoz, I</creatorcontrib><creatorcontrib>Vosmik, F</creatorcontrib><creatorcontrib>Blaszczyk, B</creatorcontrib><creatorcontrib>Krejci, J</creatorcontrib><creatorcontrib>Pekarek, J</creatorcontrib><creatorcontrib>Hraba, T</creatorcontrib><creatorcontrib>Hala, K</creatorcontrib><title>Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens</title><title>Agents and Actions</title><addtitle>Agents Actions</addtitle><description>Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. Significant reduction of anti-HSA titres was found after 50 mg/animal doses of 6-mercaptopurine, colcemid (1 mg/KBW), 25 MG/KBW or cyclophosphamide and after the methotrexate treatment.</description><subject>animal diseases</subject><subject>animal health</subject><subject>Animals</subject><subject>Chickens</subject><subject>Comb and Wattles - pathology</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Dactinomycin - pharmacology</subject><subject>Demecolcine - pharmacology</subject><subject>Hypersensitivity, Delayed - pathology</subject><subject>Hypersensitivity, Delayed - physiopathology</subject><subject>Immunization</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - toxicity</subject><subject>Mercaptopurine - pharmacology</subject><subject>Methotrexate - pharmacology</subject><subject>Tuberculin</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEURoP4qtWNa8GshdGbzCPJsharQsGFFtwNmcydNtp5kEwK_feOTNHVXZzD4fIRcs3gngGIh8cFMJUpJeURmbCEQ6RAfh6TCUCWRglX6pxceP8FkKZMsjNyKpVSQk5IPjO93dl-T9uK7rSzbfDU1nVoWh-6zqH3doe0dGHtadvQPhToTNjahm72HTqPjbeHgkM9xAZpgGZjzffALslJpbcerw53SlaLp4_5S7R8e36dz5aR4VnSR5kAVnHB0wKxQp4iQJUJk8WFSIaPRQKIiqMsDLBUIS8zLcqi4CDKWDIl4ym5G7vGtd47rPLO2Vq7fc4g_90o_99okG9GuQtFjeWfOo4y4NsRV7rN9dpZn6_eObAYeCJBgIh_ABFZbM8</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Karakoz, I</creator><creator>Vosmik, F</creator><creator>Blaszczyk, B</creator><creator>Krejci, J</creator><creator>Pekarek, J</creator><creator>Hraba, T</creator><creator>Hala, K</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197707</creationdate><title>Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens</title><author>Karakoz, I ; Vosmik, F ; Blaszczyk, B ; Krejci, J ; Pekarek, J ; Hraba, T ; Hala, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c264t-6701f2725beefe25e00f67c63b74518740ee92e8bc0159e2d6a7dbb207d381983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>animal diseases</topic><topic>animal health</topic><topic>Animals</topic><topic>Chickens</topic><topic>Comb and Wattles - pathology</topic><topic>Cyclophosphamide - pharmacology</topic><topic>Dactinomycin - pharmacology</topic><topic>Demecolcine - pharmacology</topic><topic>Hypersensitivity, Delayed - pathology</topic><topic>Hypersensitivity, Delayed - physiopathology</topic><topic>Immunization</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Immunosuppressive Agents - toxicity</topic><topic>Mercaptopurine - pharmacology</topic><topic>Methotrexate - pharmacology</topic><topic>Tuberculin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karakoz, I</creatorcontrib><creatorcontrib>Vosmik, F</creatorcontrib><creatorcontrib>Blaszczyk, B</creatorcontrib><creatorcontrib>Krejci, J</creatorcontrib><creatorcontrib>Pekarek, J</creatorcontrib><creatorcontrib>Hraba, T</creatorcontrib><creatorcontrib>Hala, K</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karakoz, I</au><au>Vosmik, F</au><au>Blaszczyk, B</au><au>Krejci, J</au><au>Pekarek, J</au><au>Hraba, T</au><au>Hala, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1977-07</date><risdate>1977</risdate><volume>7</volume><issue>2</issue><spage>299</spage><epage>304</epage><pages>299-304</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>Drug induced immunosuppression of chicken immune response was studied in F1 hybrids of the CB and IC inbred lines. In tuberculin reaction complete inhibition of wattle swelling was induced by the administration of methotrexate, colcemid (1 mg/KBW), and 6-mercaptopurine. The cellular infiltration was substantially reduced in these cases. Cyclophosphamide and colcemid (0.1 mg/KBW) reduced partially the wattle swelling but had no apparent effect on the cellular infiltration. Acetinomycin D did not affect in measurable degree the wattle swelling. The histologic picture was in this case the same as in the control animals. The same drug administration schedule had less pronounced effect on anti-HSA antibody production. No anti-HSA antibody was found after the 500 mg/animal doses of 6-mercaptopurine. Significant reduction of anti-HSA titres was found after 50 mg/animal doses of 6-mercaptopurine, colcemid (1 mg/KBW), 25 MG/KBW or cyclophosphamide and after the methotrexate treatment.</abstract><cop>Switzerland</cop><pmid>899978</pmid><doi>10.1007/BF01969988</doi><tpages>6</tpages></addata></record> |
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subjects | animal diseases animal health Animals Chickens Comb and Wattles - pathology Cyclophosphamide - pharmacology Dactinomycin - pharmacology Demecolcine - pharmacology Hypersensitivity, Delayed - pathology Hypersensitivity, Delayed - physiopathology Immunization Immunosuppressive Agents - pharmacology Immunosuppressive Agents - toxicity Mercaptopurine - pharmacology Methotrexate - pharmacology Tuberculin |
title | Activity of various immunosuppressive drugs on tuberculin hypersensitivity reaction in chickens |
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