use of cyclophosphamide as an enhancer of the vaccine against foot-and-mouth disease
The immunization of biungulate animals with killed foot-and-mouth disease virus (FMDV) requires periodic vaccinations due to a low vaccine immunogenicity. Therefore, FMDV antigens need to be combined with adjuvants such as aluminium hydroxide, saponin or oil emulsions. Animal handling for periodic i...
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| Veröffentlicht in: | Experientia 1996, Vol.52 (6), p.605-607 |
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| creator | Portiansky, E.L Gonzalez, P.H Laguens, R.P |
| description | The immunization of biungulate animals with killed foot-and-mouth disease virus (FMDV) requires periodic vaccinations due to a low vaccine immunogenicity. Therefore, FMDV antigens need to be combined with adjuvants such as aluminium hydroxide, saponin or oil emulsions. Animal handling for periodic inoculations, and the repeated doses of vaccines that have to be administered increase the commercialization costs. Moreover, the use of adjuvants may induce adverse effects. In the present work we show that it is possible to increase the life span of neutralizing antibodies in serum when a single dose of cyclophosphamide (Cy) is administered four days before vaccination with aluminium hydroxidesaponin FMDV vaccine. |
| doi_str_mv | 10.1007/BF01969738 |
| format | Article |
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Therefore, FMDV antigens need to be combined with adjuvants such as aluminium hydroxide, saponin or oil emulsions. Animal handling for periodic inoculations, and the repeated doses of vaccines that have to be administered increase the commercialization costs. Moreover, the use of adjuvants may induce adverse effects. In the present work we show that it is possible to increase the life span of neutralizing antibodies in serum when a single dose of cyclophosphamide (Cy) is administered four days before vaccination with aluminium hydroxidesaponin FMDV vaccine.</description><identifier>ISSN: 0014-4754</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/BF01969738</identifier><identifier>PMID: 8698098</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; antibodies ; antibody formation ; Aphthovirus ; Aphthovirus - immunology ; Cattle ; Cattle Diseases - prevention & control ; cyclophosphamide ; Cyclophosphamide - adverse effects ; Cyclophosphamide - therapeutic use ; Female ; Foot-and-Mouth Disease - prevention & control ; foot-and-mouth disease virus ; heifers ; immunostimulation ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - therapeutic use ; Leukopenia - chemically induced ; live vaccines ; neutralizing antibodies ; protective antigens ; viral antigens ; Viral Vaccines ; virus neutralization</subject><ispartof>Experientia, 1996, Vol.52 (6), p.605-607</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c332t-6d78360e72e90d0839631864060afe96907070209429df8bad9fd08c16fda2563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8698098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Portiansky, E.L</creatorcontrib><creatorcontrib>Gonzalez, P.H</creatorcontrib><creatorcontrib>Laguens, R.P</creatorcontrib><title>use of cyclophosphamide as an enhancer of the vaccine against foot-and-mouth disease</title><title>Experientia</title><addtitle>Experientia</addtitle><description>The immunization of biungulate animals with killed foot-and-mouth disease virus (FMDV) requires periodic vaccinations due to a low vaccine immunogenicity. 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| fulltext | fulltext |
| identifier | ISSN: 0014-4754 |
| ispartof | Experientia, 1996, Vol.52 (6), p.605-607 |
| issn | 0014-4754 1420-9071 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01969738 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals antibodies antibody formation Aphthovirus Aphthovirus - immunology Cattle Cattle Diseases - prevention & control cyclophosphamide Cyclophosphamide - adverse effects Cyclophosphamide - therapeutic use Female Foot-and-Mouth Disease - prevention & control foot-and-mouth disease virus heifers immunostimulation Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Leukopenia - chemically induced live vaccines neutralizing antibodies protective antigens viral antigens Viral Vaccines virus neutralization |
| title | use of cyclophosphamide as an enhancer of the vaccine against foot-and-mouth disease |
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