Calcium-dependent histidine and histamine release from superfused synaptosomes
The release of radioactive histidine and histamine was studied in a superfusion system by using guinea pig synaptosomes which were preloaded with 3H-histidine. Depolarization by 50 mM K+ induced a simultaneous release of histidine and histamine. The stimulated release of both of these substances was...
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| Veröffentlicht in: | Agents and Actions 1990-04, Vol.30 (1-2), p.220-222 |
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| container_end_page | 222 |
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| container_title | Agents and Actions |
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| creator | Tikkanen, T Raatikainen, O Tuomisto, L |
| description | The release of radioactive histidine and histamine was studied in a superfusion system by using guinea pig synaptosomes which were preloaded with 3H-histidine. Depolarization by 50 mM K+ induced a simultaneous release of histidine and histamine. The stimulated release of both of these substances was diminished when calcium was removed. The calcium-dependency of histamine release, previously demonstrated in brain slices, was confirmed using synaptosomes. It was also demonstrated that potassium-induced histidine release from guinea pig synaptosomes under superfusion conditions is at least partially calcium-dependent. |
| doi_str_mv | 10.1007/BF01969043 |
| format | Article |
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Depolarization by 50 mM K+ induced a simultaneous release of histidine and histamine. The stimulated release of both of these substances was diminished when calcium was removed. The calcium-dependency of histamine release, previously demonstrated in brain slices, was confirmed using synaptosomes. 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It was also demonstrated that potassium-induced histidine release from guinea pig synaptosomes under superfusion conditions is at least partially calcium-dependent.</description><subject>Animals</subject><subject>Calcium - physiology</subject><subject>Guinea Pigs</subject><subject>Histamine Release - drug effects</subject><subject>Histidine - metabolism</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Potassium - pharmacology</subject><subject>Synaptosomes - drug effects</subject><subject>Synaptosomes - metabolism</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AURQdRaq1u3AtZuRCib76SzFKLVaHoRsFdmM68YCSTxHnJov--rS10dblwOIvD2DWHew6QPzwtgJvMgJInbMqVgNRA8X3KpgCZTpUw5pxdEP0CaM0LPmETnhmtlJqy97ltXD2G1GOPrcd2SH5qGmpft5jY1v8_G3YvYoOWMKliFxIae4zVSOgTWre2HzrqAtIlO6tsQ3h12Bn7Wjx_zl_T5cfL2_xxmTqh-JCiNsJoaYVb-Yp7byvvnM9UxsEa5VZCmCwXSkl0SmW584VBKAA914WptJczdrv39rH7G5GGMtTksGlsi91IZW6KQnKpt-DdHnSxI4pYlX2sg43rkkO5i1ce423hm4N1XAX0R3RfS24AEcpqxw</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Tikkanen, T</creator><creator>Raatikainen, O</creator><creator>Tuomisto, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199004</creationdate><title>Calcium-dependent histidine and histamine release from superfused synaptosomes</title><author>Tikkanen, T ; Raatikainen, O ; Tuomisto, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-e592953a2cbdf1ddafdccd64610a94cb229672443ec4467cd89e080ed1589f5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Calcium - physiology</topic><topic>Guinea Pigs</topic><topic>Histamine Release - drug effects</topic><topic>Histidine - metabolism</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Potassium - pharmacology</topic><topic>Synaptosomes - drug effects</topic><topic>Synaptosomes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tikkanen, T</creatorcontrib><creatorcontrib>Raatikainen, O</creatorcontrib><creatorcontrib>Tuomisto, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tikkanen, T</au><au>Raatikainen, O</au><au>Tuomisto, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium-dependent histidine and histamine release from superfused synaptosomes</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1990-04</date><risdate>1990</risdate><volume>30</volume><issue>1-2</issue><spage>220</spage><epage>222</epage><pages>220-222</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>The release of radioactive histidine and histamine was studied in a superfusion system by using guinea pig synaptosomes which were preloaded with 3H-histidine. 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| fulltext | fulltext |
| identifier | ISSN: 0065-4299 |
| ispartof | Agents and Actions, 1990-04, Vol.30 (1-2), p.220-222 |
| issn | 0065-4299 1420-908X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Calcium - physiology Guinea Pigs Histamine Release - drug effects Histidine - metabolism In Vitro Techniques Male Potassium - pharmacology Synaptosomes - drug effects Synaptosomes - metabolism |
| title | Calcium-dependent histidine and histamine release from superfused synaptosomes |
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