Platelet heterogeneity and dense tubular system changes on activation

Platelets impregnated with heavy metals appeared as 3 distinct morphological types: 'reticular' cells with a polygonal dense tubular network and stained granules, dark metallophilic cells, and pale metallophobic cells with microvesicles and non-staining granules. On stimulation, type 1 cel...

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Veröffentlicht in:	Experientia 1981-01, Vol.37 (1), p.96-98
Hauptverfasser:	Yarom, R, Lijovetzky, G, Havivi, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adolescent Adult Blood Platelets - drug effects Blood Platelets - ultrastructure Cytoplasm - ultrastructure Cytoplasmic Granules - ultrastructure Female Humans Male Metals Microscopy, Electron Staining and Labeling Thrombin - pharmacology
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description	Platelets impregnated with heavy metals appeared as 3 distinct morphological types: 'reticular' cells with a polygonal dense tubular network and stained granules, dark metallophilic cells, and pale metallophobic cells with microvesicles and non-staining granules. On stimulation, type 1 cells decreased while type 3 cells increased, suggesting that with activation dense tubules break up into microvesicles and granules become metallophobic. In the type 2 cells a different functional mechanism may exist.
doi_str_mv	10.1007/BF01965592
format	Article
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In the type 2 cells a different functional mechanism may exist.</description><subject>Adenosine Diphosphate - pharmacology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - ultrastructure</subject><subject>Cytoplasm - ultrastructure</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Metals</subject><subject>Microscopy, Electron</subject><subject>Staining and Labeling</subject><subject>Thrombin - pharmacology</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYxoMoc04v3oWcPAjVN2k-mqOO-QEDPei5ZOmbrdKms0mF_fdWNvTyPPDw4zn8CLlkcMsA9N3DIzCjpDT8iEyZ4JAZ0OyYTAGYyISW4pScxfgJkINkakImiimutJySxVtjEzaY6AYT9t0aA9ZpR22oaIUhIk3DamhsT-MuJmyp29iwxki7QK1L9bdNdRfOyYm3TcSLQ8_Ix-Piff6cLV-fXub3y8zxgqdMskopox2X2vtKaQ-8QKk8B6bHKEThxlHb3LtCOw_GKJuvBDJuBNd5kc_I9f5323dfA8ZUtnV02DQ2YDfEUkupGZNyBG_2oOu7GHv05bavW9vvSgblr7Py39kIXx1eh1WL1R96kJT_AGEMZZY</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Yarom, R</creator><creator>Lijovetzky, G</creator><creator>Havivi, Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810101</creationdate><title>Platelet heterogeneity and dense tubular system changes on activation</title><author>Yarom, R ; Lijovetzky, G ; Havivi, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-51d6697c257ffd67f028e56f2017f20848c67f7a3fc87cf0996a3b4e129427383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adenosine Diphosphate - pharmacology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - ultrastructure</topic><topic>Cytoplasm - ultrastructure</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Metals</topic><topic>Microscopy, Electron</topic><topic>Staining and Labeling</topic><topic>Thrombin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yarom, R</creatorcontrib><creatorcontrib>Lijovetzky, G</creatorcontrib><creatorcontrib>Havivi, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yarom, R</au><au>Lijovetzky, G</au><au>Havivi, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet heterogeneity and dense tubular system changes on activation</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>37</volume><issue>1</issue><spage>96</spage><epage>98</epage><pages>96-98</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><abstract>Platelets impregnated with heavy metals appeared as 3 distinct morphological types: 'reticular' cells with a polygonal dense tubular network and stained granules, dark metallophilic cells, and pale metallophobic cells with microvesicles and non-staining granules. 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source	MEDLINE; SpringerLink Journals
subjects	Adenosine Diphosphate - pharmacology Adolescent Adult Blood Platelets - drug effects Blood Platelets - ultrastructure Cytoplasm - ultrastructure Cytoplasmic Granules - ultrastructure Female Humans Male Metals Microscopy, Electron Staining and Labeling Thrombin - pharmacology
title	Platelet heterogeneity and dense tubular system changes on activation
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