Surfactant replacement therapy : a new risk factor in developing retinopathy of prematurity ?
We documented the prevalence of retinopathy of prematurity (ROP) in a group of 46 infants suffering from a moderate or severe respiratory distress syndrome and treated with surfactant replacement therapy (SRT) and 61 controls admitted in the year prior to the institution of SRT. Mortality in the tre...
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| Veröffentlicht in: | European journal of pediatrics 1994-02, Vol.153 (2), p.113-116 |
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| container_title | European journal of pediatrics |
| container_volume | 153 |
| creator | TERMOTE, J. U. M SCHALIJ-DELFOS, N. E WITTEBOL-POST, D BROUWERS, H. A. A HOOGERVORST, B. R CATS, B. P |
| description | We documented the prevalence of retinopathy of prematurity (ROP) in a group of 46 infants suffering from a moderate or severe respiratory distress syndrome and treated with surfactant replacement therapy (SRT) and 61 controls admitted in the year prior to the institution of SRT. Mortality in the treatment group was lower than in the control group (15.5% versus 23.8; P = 0.29). The ROP prevalence in the treatment group was 47.8% and in the control group 27.9%. To analyse the contribution of SRT alone to the prevalence of ROP, multivariate analysis using logistic regression technique was used. The odds ratio for SRT was 5.2 with a 95% confidence interval of 1.3-20.7, P = 0.02. The prevalence of severe ROP in the surfactant treated group was not increased compared to the control group. From our data we conclude that SRT increases the risk of developing ROP but is not associated with more severe forms of ROP. |
| doi_str_mv | 10.1007/BF01959221 |
| format | Article |
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U. M ; SCHALIJ-DELFOS, N. E ; WITTEBOL-POST, D ; BROUWERS, H. A. A ; HOOGERVORST, B. R ; CATS, B. P</creator><creatorcontrib>TERMOTE, J. U. M ; SCHALIJ-DELFOS, N. E ; WITTEBOL-POST, D ; BROUWERS, H. A. A ; HOOGERVORST, B. R ; CATS, B. P</creatorcontrib><description>We documented the prevalence of retinopathy of prematurity (ROP) in a group of 46 infants suffering from a moderate or severe respiratory distress syndrome and treated with surfactant replacement therapy (SRT) and 61 controls admitted in the year prior to the institution of SRT. Mortality in the treatment group was lower than in the control group (15.5% versus 23.8; P = 0.29). The ROP prevalence in the treatment group was 47.8% and in the control group 27.9%. To analyse the contribution of SRT alone to the prevalence of ROP, multivariate analysis using logistic regression technique was used. The odds ratio for SRT was 5.2 with a 95% confidence interval of 1.3-20.7, P = 0.02. The prevalence of severe ROP in the surfactant treated group was not increased compared to the control group. From our data we conclude that SRT increases the risk of developing ROP but is not associated with more severe forms of ROP.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/BF01959221</identifier><identifier>PMID: 8157017</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Humans ; Infant, Newborn ; Intensive care medicine ; Medical sciences ; Pulmonary Surfactants - adverse effects ; Pulmonary Surfactants - therapeutic use ; Respiratory Distress Syndrome, Newborn - drug therapy ; Retinopathy of Prematurity - chemically induced ; Retrospective Studies ; Risk Factors</subject><ispartof>European journal of pediatrics, 1994-02, Vol.153 (2), p.113-116</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-437c45856a7f39387d32d965dcf32e18c515aa86a959e051f9baa3f684c064b53</citedby><cites>FETCH-LOGICAL-c311t-437c45856a7f39387d32d965dcf32e18c515aa86a959e051f9baa3f684c064b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3881099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8157017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TERMOTE, J. U. M</creatorcontrib><creatorcontrib>SCHALIJ-DELFOS, N. E</creatorcontrib><creatorcontrib>WITTEBOL-POST, D</creatorcontrib><creatorcontrib>BROUWERS, H. A. A</creatorcontrib><creatorcontrib>HOOGERVORST, B. R</creatorcontrib><creatorcontrib>CATS, B. P</creatorcontrib><title>Surfactant replacement therapy : a new risk factor in developing retinopathy of prematurity ?</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>We documented the prevalence of retinopathy of prematurity (ROP) in a group of 46 infants suffering from a moderate or severe respiratory distress syndrome and treated with surfactant replacement therapy (SRT) and 61 controls admitted in the year prior to the institution of SRT. Mortality in the treatment group was lower than in the control group (15.5% versus 23.8; P = 0.29). The ROP prevalence in the treatment group was 47.8% and in the control group 27.9%. To analyse the contribution of SRT alone to the prevalence of ROP, multivariate analysis using logistic regression technique was used. The odds ratio for SRT was 5.2 with a 95% confidence interval of 1.3-20.7, P = 0.02. The prevalence of severe ROP in the surfactant treated group was not increased compared to the control group. From our data we conclude that SRT increases the risk of developing ROP but is not associated with more severe forms of ROP.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Pulmonary Surfactants - adverse effects</subject><subject>Pulmonary Surfactants - therapeutic use</subject><subject>Respiratory Distress Syndrome, Newborn - drug therapy</subject><subject>Retinopathy of Prematurity - chemically induced</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotVYv3oUcPAmrmc1mN_EitVgVCh7UoyzTbGJX94skVfbfu6Wlnmbgfd6BeQg5B3YNjGU393MGSqg4hgMyhoTHEbAsPSRjxhMWpaDUMTnx_osNsAI5IiMJImOQjcnH69pZ1AGbQJ3pKtSmNsMeVsZh19NbirQxv9SV_ptuwNbRsqGF-TFV25XN59AKZdN2GFY9bS3tnKkxrF0Zenp3So4sVt6c7eaEvM8f3mZP0eLl8Xk2XUSaA4Qo4ZlOhBQpZpYrLrOCx4VKRaEtjw1ILUAgyhSHJw0TYNUSkdtUJpqlyVLwCbna3tWu9d4Zm3eurNH1ObB8oyj_VzTAF1u4Wy9rU-zRnZMhv9zl6DVW1mGjS7_HuJTAlOJ_n65tnA</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>TERMOTE, J. U. M</creator><creator>SCHALIJ-DELFOS, N. E</creator><creator>WITTEBOL-POST, D</creator><creator>BROUWERS, H. A. A</creator><creator>HOOGERVORST, B. R</creator><creator>CATS, B. P</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19940201</creationdate><title>Surfactant replacement therapy : a new risk factor in developing retinopathy of prematurity ?</title><author>TERMOTE, J. U. M ; SCHALIJ-DELFOS, N. E ; WITTEBOL-POST, D ; BROUWERS, H. A. A ; HOOGERVORST, B. R ; CATS, B. P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-437c45856a7f39387d32d965dcf32e18c515aa86a959e051f9baa3f684c064b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Pulmonary Surfactants - adverse effects</topic><topic>Pulmonary Surfactants - therapeutic use</topic><topic>Respiratory Distress Syndrome, Newborn - drug therapy</topic><topic>Retinopathy of Prematurity - chemically induced</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TERMOTE, J. U. M</creatorcontrib><creatorcontrib>SCHALIJ-DELFOS, N. E</creatorcontrib><creatorcontrib>WITTEBOL-POST, D</creatorcontrib><creatorcontrib>BROUWERS, H. A. A</creatorcontrib><creatorcontrib>HOOGERVORST, B. R</creatorcontrib><creatorcontrib>CATS, B. 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P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactant replacement therapy : a new risk factor in developing retinopathy of prematurity ?</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>153</volume><issue>2</issue><spage>113</spage><epage>116</epage><pages>113-116</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><coden>EJPEDT</coden><abstract>We documented the prevalence of retinopathy of prematurity (ROP) in a group of 46 infants suffering from a moderate or severe respiratory distress syndrome and treated with surfactant replacement therapy (SRT) and 61 controls admitted in the year prior to the institution of SRT. Mortality in the treatment group was lower than in the control group (15.5% versus 23.8; P = 0.29). The ROP prevalence in the treatment group was 47.8% and in the control group 27.9%. To analyse the contribution of SRT alone to the prevalence of ROP, multivariate analysis using logistic regression technique was used. The odds ratio for SRT was 5.2 with a 95% confidence interval of 1.3-20.7, P = 0.02. The prevalence of severe ROP in the surfactant treated group was not increased compared to the control group. From our data we conclude that SRT increases the risk of developing ROP but is not associated with more severe forms of ROP.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>8157017</pmid><doi>10.1007/BF01959221</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pediatrics, 1994-02, Vol.153 (2), p.113-116 |
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| language | eng |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: neonates and children. Prematurity. Sudden death Humans Infant, Newborn Intensive care medicine Medical sciences Pulmonary Surfactants - adverse effects Pulmonary Surfactants - therapeutic use Respiratory Distress Syndrome, Newborn - drug therapy Retinopathy of Prematurity - chemically induced Retrospective Studies Risk Factors |
| title | Surfactant replacement therapy : a new risk factor in developing retinopathy of prematurity ? |
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