Effect of in vivo pre-treatment with oestradiol and either GnRH, GnRH agonistic analog or GnRH antagonistic analog on GnRH-stimulated secretion of LH in vitro
In vivo treatment with GnRH or with GnRH agonistic analog (AG), but not with GnRH antagonistic analog (ANT), depleted the LH stores of the rat pituitary gland. This depletion was potentiated by oestradiol. Oestradiol augmented the in vitro LH response of the pituitary gland to GnRH. This augmenting...
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| Veröffentlicht in: | Experientia 1991-07, Vol.47 (7), p.716-718 |
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| container_title | Experientia |
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| creator | SCHUILING, G. A KOITER, T. R MOES, H |
| description | In vivo treatment with GnRH or with GnRH agonistic analog (AG), but not with GnRH antagonistic analog (ANT), depleted the LH stores of the rat pituitary gland. This depletion was potentiated by oestradiol. Oestradiol augmented the in vitro LH response of the pituitary gland to GnRH. This augmenting effect of oestradiol became smaller with increasing rates of in vivo administration of GnRH or AG, but not with ANT. With respect to both depletion of the LH stores and suppression of the augmenting effect of oestradiol, AG ist about 20 times as potent as GnRH. |
| doi_str_mv | 10.1007/BF01958824 |
| format | Article |
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With respect to both depletion of the LH stores and suppression of the augmenting effect of oestradiol, AG ist about 20 times as potent as GnRH.</description><identifier>ISSN: 0014-4754</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/BF01958824</identifier><identifier>PMID: 1906009</identifier><identifier>CODEN: EXPEAM</identifier><language>eng</language><publisher>Basel: Birkhäuser</publisher><subject>Animals ; Biological and medical sciences ; Buserelin - pharmacology ; Estradiol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gonadotropin-Releasing Hormone - analogs & derivatives ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Gonadotropin-Releasing Hormone - pharmacology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Luteinizing Hormone - metabolism ; Pituitary Gland - metabolism ; Rats ; Rats, Inbred Strains ; Vertebrates: endocrinology</subject><ispartof>Experientia, 1991-07, Vol.47 (7), p.716-718</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c216t-811f573f223d7cd77ef3a6346a4f22b75062229ca2f643f28e1c187faa8d9c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5597564$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1906009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHUILING, G. A</creatorcontrib><creatorcontrib>KOITER, T. R</creatorcontrib><creatorcontrib>MOES, H</creatorcontrib><title>Effect of in vivo pre-treatment with oestradiol and either GnRH, GnRH agonistic analog or GnRH antagonistic analog on GnRH-stimulated secretion of LH in vitro</title><title>Experientia</title><addtitle>Experientia</addtitle><description>In vivo treatment with GnRH or with GnRH agonistic analog (AG), but not with GnRH antagonistic analog (ANT), depleted the LH stores of the rat pituitary gland. This depletion was potentiated by oestradiol. Oestradiol augmented the in vitro LH response of the pituitary gland to GnRH. This augmenting effect of oestradiol became smaller with increasing rates of in vivo administration of GnRH or AG, but not with ANT. With respect to both depletion of the LH stores and suppression of the augmenting effect of oestradiol, AG ist about 20 times as potent as GnRH.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Buserelin - pharmacology</subject><subject>Estradiol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadotropin-Releasing Hormone - analogs & derivatives</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Pituitary Gland - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: endocrinology</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFDEUx4Modbt68S7kIB6Koy-ZSTJzrKXtCguC6Hl4zbzUyEyyJtmKX8bPauwu9uDBSwLv9-PlvfwZeyHgrQAw795fgRhU38vuEVuJTkIzgBGP2QpAdE1nVPeUneb8DaAFJfQJOxEDaIBhxX5dOke28Oi4D_zO30W-S9SURFgWCoX_8OUrj5RLwsnHmWOYONUaJX4dPm3e3J8cb2PwuXhbOc7xlsd0BKH8y8I9a2pt2c9YaOKZbKLiK6mDbDeHWUqKz9gTh3Om58d7zb5cXX6-2DTbj9cfLs63jZVCl6YXwinTOinbydjJGHIt6rbT2NXajVGgpZSDRel0V7WehBW9cYj9NFg1tWv2-tB3l-L3fd12XHy2NM8YKO7z2IPWsh30f0WhBqPb-tFrdnYQbYo5J3LjLvkF089RwPgntfEhtSq_PHbd3yw0PaiHmCp_deSYLc4uYbA-_9VUfVTVxX4D1Tqe2Q</recordid><startdate>19910715</startdate><enddate>19910715</enddate><creator>SCHUILING, G. 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R ; MOES, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c216t-811f573f223d7cd77ef3a6346a4f22b75062229ca2f643f28e1c187faa8d9c5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Buserelin - pharmacology</topic><topic>Estradiol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadotropin-Releasing Hormone - analogs & derivatives</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Pituitary Gland - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHUILING, G. A</creatorcontrib><creatorcontrib>KOITER, T. R</creatorcontrib><creatorcontrib>MOES, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHUILING, G. A</au><au>KOITER, T. R</au><au>MOES, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of in vivo pre-treatment with oestradiol and either GnRH, GnRH agonistic analog or GnRH antagonistic analog on GnRH-stimulated secretion of LH in vitro</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1991-07-15</date><risdate>1991</risdate><volume>47</volume><issue>7</issue><spage>716</spage><epage>718</epage><pages>716-718</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><coden>EXPEAM</coden><abstract>In vivo treatment with GnRH or with GnRH agonistic analog (AG), but not with GnRH antagonistic analog (ANT), depleted the LH stores of the rat pituitary gland. This depletion was potentiated by oestradiol. Oestradiol augmented the in vitro LH response of the pituitary gland to GnRH. This augmenting effect of oestradiol became smaller with increasing rates of in vivo administration of GnRH or AG, but not with ANT. With respect to both depletion of the LH stores and suppression of the augmenting effect of oestradiol, AG ist about 20 times as potent as GnRH.</abstract><cop>Basel</cop><cop>Boston, MA</cop><cop>Berlin</cop><pub>Birkhäuser</pub><pmid>1906009</pmid><doi>10.1007/BF01958824</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4754 |
| ispartof | Experientia, 1991-07, Vol.47 (7), p.716-718 |
| issn | 0014-4754 1420-9071 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01958824 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Buserelin - pharmacology Estradiol - pharmacology Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - pharmacology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Luteinizing Hormone - metabolism Pituitary Gland - metabolism Rats Rats, Inbred Strains Vertebrates: endocrinology |
| title | Effect of in vivo pre-treatment with oestradiol and either GnRH, GnRH agonistic analog or GnRH antagonistic analog on GnRH-stimulated secretion of LH in vitro |
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