Adrenocortical metabolism and plasma corticosterone in soman intoxicated rabbits
The organophosphate neurotoxin soman produced impairments in adrenocortical RNA and protein metabolism. Fasciculate and reticular cell RNA and protein contents were suppressed with sublethal to acutely lethal dosages (20, 30 and 40 micrograms/kg, s.c.) during the acute excitatory phase of intoxicati...
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| Veröffentlicht in: | Experientia 1985-09, Vol.41 (9), p.1145-1147 |
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| container_title | Experientia |
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| creator | DOEBLER, J. A WICKERSHAM, E. W POLAKOVIC, L. V SHIH, T.-M ANTHONY, A |
| description | The organophosphate neurotoxin soman produced impairments in adrenocortical RNA and protein metabolism. Fasciculate and reticular cell RNA and protein contents were suppressed with sublethal to acutely lethal dosages (20, 30 and 40 micrograms/kg, s.c.) during the acute excitatory phase of intoxication and at 6-8 h post injection. All three dosages produced ca 90% inactivation of plasma cholinesterase. A transient elevation of plasma corticosterone occurred with 20 micrograms/kg soman whereas there was a protracted increase with 30 micrograms/kg. Corticosterone was not significantly elevated with 40 micrograms/kg, but death occurred at 13 +/- 4 min. Thus, the magnitude and/or nature of soman-induced metabolic impairments does not appear to prevent adrenal activation. |
| doi_str_mv | 10.1007/BF01951700 |
| format | Article |
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Thus, the magnitude and/or nature of soman-induced metabolic impairments does not appear to prevent adrenal activation.</description><identifier>ISSN: 0014-4754</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/BF01951700</identifier><identifier>PMID: 2412881</identifier><identifier>CODEN: EXPEAM</identifier><language>eng</language><publisher>Basel: Birkhäuser</publisher><subject>adrenal cortex ; Adrenal Cortex - metabolism ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. 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A</creatorcontrib><creatorcontrib>WICKERSHAM, E. W</creatorcontrib><creatorcontrib>POLAKOVIC, L. V</creatorcontrib><creatorcontrib>SHIH, T.-M</creatorcontrib><creatorcontrib>ANTHONY, A</creatorcontrib><title>Adrenocortical metabolism and plasma corticosterone in soman intoxicated rabbits</title><title>Experientia</title><addtitle>Experientia</addtitle><description>The organophosphate neurotoxin soman produced impairments in adrenocortical RNA and protein metabolism. Fasciculate and reticular cell RNA and protein contents were suppressed with sublethal to acutely lethal dosages (20, 30 and 40 micrograms/kg, s.c.) during the acute excitatory phase of intoxication and at 6-8 h post injection. All three dosages produced ca 90% inactivation of plasma cholinesterase. A transient elevation of plasma corticosterone occurred with 20 micrograms/kg soman whereas there was a protracted increase with 30 micrograms/kg. Corticosterone was not significantly elevated with 40 micrograms/kg, but death occurred at 13 +/- 4 min. Thus, the magnitude and/or nature of soman-induced metabolic impairments does not appear to prevent adrenal activation.</description><subject>adrenal cortex</subject><subject>Adrenal Cortex - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cholinesterases - metabolism</subject><subject>corticosterone</subject><subject>Corticosterone - blood</subject><subject>Medical sciences</subject><subject>Proteins - analysis</subject><subject>Rabbits</subject><subject>RNA - analysis</subject><subject>soman</subject><subject>Soman - toxicity</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9Lw0AQhRdRaq1evAs5iAchOrM_kt1jLVaFgh70HCabDUSSbN1NQf97Iw31NAPve-_wMXaJcIcA-f3DGtAozAGO2Bwlh9RAjsdsDoAylbmSp-wsxk8AAQqzGZtxiVxrnLO3ZRVc760PQ2OpTTo3UOnbJnYJ9VWybSl2lOxjHwcXfO-Spk-i76gfn8F_j73BVUmgsmyGeM5Oamqju5jugn2sH99Xz-nm9elltdykVkg-pCXpEpE4SkNoKcuNQCBVG0kKMq1NpnTFjbEZd464ykoL0tS2qpXK8qwSC3az390G_7VzcSi6JlrXttQ7v4sFSsGVEmIEb_egDT7G4OpiG5qOwk-BUPzpK_71jfDVtLorO1cd0MnXmF9POcVRVx2ot008YFoZDVqJX0z5dt0</recordid><startdate>19850915</startdate><enddate>19850915</enddate><creator>DOEBLER, J. 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A</creatorcontrib><creatorcontrib>WICKERSHAM, E. W</creatorcontrib><creatorcontrib>POLAKOVIC, L. V</creatorcontrib><creatorcontrib>SHIH, T.-M</creatorcontrib><creatorcontrib>ANTHONY, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Endocrinology Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DOEBLER, J. A</au><au>WICKERSHAM, E. W</au><au>POLAKOVIC, L. V</au><au>SHIH, T.-M</au><au>ANTHONY, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenocortical metabolism and plasma corticosterone in soman intoxicated rabbits</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1985-09-15</date><risdate>1985</risdate><volume>41</volume><issue>9</issue><spage>1145</spage><epage>1147</epage><pages>1145-1147</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><coden>EXPEAM</coden><abstract>The organophosphate neurotoxin soman produced impairments in adrenocortical RNA and protein metabolism. Fasciculate and reticular cell RNA and protein contents were suppressed with sublethal to acutely lethal dosages (20, 30 and 40 micrograms/kg, s.c.) during the acute excitatory phase of intoxication and at 6-8 h post injection. All three dosages produced ca 90% inactivation of plasma cholinesterase. A transient elevation of plasma corticosterone occurred with 20 micrograms/kg soman whereas there was a protracted increase with 30 micrograms/kg. Corticosterone was not significantly elevated with 40 micrograms/kg, but death occurred at 13 +/- 4 min. Thus, the magnitude and/or nature of soman-induced metabolic impairments does not appear to prevent adrenal activation.</abstract><cop>Basel</cop><cop>Boston, MA</cop><cop>Berlin</cop><pub>Birkhäuser</pub><pmid>2412881</pmid><doi>10.1007/BF01951700</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4754 |
| ispartof | Experientia, 1985-09, Vol.41 (9), p.1145-1147 |
| issn | 0014-4754 1420-9071 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | adrenal cortex Adrenal Cortex - metabolism Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cholinesterases - metabolism corticosterone Corticosterone - blood Medical sciences Proteins - analysis Rabbits RNA - analysis soman Soman - toxicity Toxicology Various organic compounds |
| title | Adrenocortical metabolism and plasma corticosterone in soman intoxicated rabbits |
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