Monoclonal antibodies against antigens on breast cancer cells
Of 360 mAb obtained in a cell fusion experiment with the spleen cells of a mouse immunized with a mixture of different human breast carcinoma cell lines, 30 mAb were selected which reacted more strongly with tumor cells than with (noncancerous) fibroblasts. These mAb were tested for reactivity with...
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| Veröffentlicht in: | Experientia 1985-11, Vol.41 (11), p.1377-1381 |
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| container_issue | 11 |
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| container_title | Experientia |
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| creator | STAHLI, C TAKACS, B MIGGIANO, V STAEHELIN, T CARMANN, H |
| description | Of 360 mAb obtained in a cell fusion experiment with the spleen cells of a mouse immunized with a mixture of different human breast carcinoma cell lines, 30 mAb were selected which reacted more strongly with tumor cells than with (noncancerous) fibroblasts. These mAb were tested for reactivity with additional types of cancerous and noncancerous tissues. Two mAb showed high tumor selectivity, but the corresponding epitopes on individual tumor cells were heterogeneously expressed. The mAb will be evaluated for in vivo applications. |
| doi_str_mv | 10.1007/BF01949996 |
| format | Article |
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Experimental tumors ; Animals ; Antibodies, Monoclonal - immunology ; Antibody Specificity ; antigen (tumor-associated) ; Antigens, Neoplasm - immunology ; Biological and medical sciences ; breast ; Breast Neoplasms - immunology ; carcinoma ; Cell Line ; cell surface ; Epitopes - immunology ; Experimental genital and mammary tumors ; Female ; Fibroblasts - immunology ; Fluorescent Antibody Technique ; Histocytochemistry ; Humans ; Hybridomas - immunology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; monoclonal antibodies ; Tumors</subject><ispartof>Experientia, 1985-11, Vol.41 (11), p.1377-1381</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-9c105c1180252c0ad58fdf8b6b87bb2aa5443ad7f1bbe868d015e51d3b3e1b733</citedby><cites>FETCH-LOGICAL-c342t-9c105c1180252c0ad58fdf8b6b87bb2aa5443ad7f1bbe868d015e51d3b3e1b733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8828297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2415385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STAHLI, C</creatorcontrib><creatorcontrib>TAKACS, B</creatorcontrib><creatorcontrib>MIGGIANO, V</creatorcontrib><creatorcontrib>STAEHELIN, T</creatorcontrib><creatorcontrib>CARMANN, H</creatorcontrib><title>Monoclonal antibodies against antigens on breast cancer cells</title><title>Experientia</title><addtitle>Experientia</addtitle><description>Of 360 mAb obtained in a cell fusion experiment with the spleen cells of a mouse immunized with a mixture of different human breast carcinoma cell lines, 30 mAb were selected which reacted more strongly with tumor cells than with (noncancerous) fibroblasts. These mAb were tested for reactivity with additional types of cancerous and noncancerous tissues. Two mAb showed high tumor selectivity, but the corresponding epitopes on individual tumor cells were heterogeneously expressed. The mAb will be evaluated for in vivo applications.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibody Specificity</subject><subject>antigen (tumor-associated)</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Biological and medical sciences</subject><subject>breast</subject><subject>Breast Neoplasms - immunology</subject><subject>carcinoma</subject><subject>Cell Line</subject><subject>cell surface</subject><subject>Epitopes - immunology</subject><subject>Experimental genital and mammary tumors</subject><subject>Female</subject><subject>Fibroblasts - immunology</subject><subject>Fluorescent Antibody Technique</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Hybridomas - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>monoclonal antibodies</subject><subject>Tumors</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVYv3oU9iAdhdSYfm-TgQYtVoeJFz0uSzZaV7aYm7cF_79Yu9SgMDMz78DI8hJwj3CCAvH2YAWqutS4OyBg5hVyDxEMyBkCecyn4MTlJ6ROAgcBiREaUo2BKjMnda-iCa0Nn2sx068aGqvEpMwvTdGn9e1r4LmWhy2z0pj850zkfM-fbNp2So9q0yZ8Ne0I-Zo_v0-d8_vb0Mr2f545xus61QxAOUQEV1IGphKqrWtnCKmktNUZwzkwla7TWq0JVgMILrJhlHq1kbEKudr2rGL42Pq3LZZO2H5jOh00qZcH7KeS_IHKGWlPRg9c70MWQUvR1uYrN0sTvEqHcSi3_pPbwxdC6sUtf7dHBYp9fDrlJzrR17BU1aY8pRRXVkv0AYdF9PQ</recordid><startdate>19851115</startdate><enddate>19851115</enddate><creator>STAHLI, C</creator><creator>TAKACS, B</creator><creator>MIGGIANO, V</creator><creator>STAEHELIN, T</creator><creator>CARMANN, H</creator><general>Birkhäuser</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19851115</creationdate><title>Monoclonal antibodies against antigens on breast cancer cells</title><author>STAHLI, C ; TAKACS, B ; MIGGIANO, V ; STAEHELIN, T ; CARMANN, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-9c105c1180252c0ad58fdf8b6b87bb2aa5443ad7f1bbe868d015e51d3b3e1b733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibody Specificity</topic><topic>antigen (tumor-associated)</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Biological and medical sciences</topic><topic>breast</topic><topic>Breast Neoplasms - immunology</topic><topic>carcinoma</topic><topic>Cell Line</topic><topic>cell surface</topic><topic>Epitopes - immunology</topic><topic>Experimental genital and mammary tumors</topic><topic>Female</topic><topic>Fibroblasts - immunology</topic><topic>Fluorescent Antibody Technique</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Hybridomas - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>monoclonal antibodies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STAHLI, C</creatorcontrib><creatorcontrib>TAKACS, B</creatorcontrib><creatorcontrib>MIGGIANO, V</creatorcontrib><creatorcontrib>STAEHELIN, T</creatorcontrib><creatorcontrib>CARMANN, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STAHLI, C</au><au>TAKACS, B</au><au>MIGGIANO, V</au><au>STAEHELIN, T</au><au>CARMANN, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monoclonal antibodies against antigens on breast cancer cells</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1985-11-15</date><risdate>1985</risdate><volume>41</volume><issue>11</issue><spage>1377</spage><epage>1381</epage><pages>1377-1381</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><coden>EXPEAM</coden><abstract>Of 360 mAb obtained in a cell fusion experiment with the spleen cells of a mouse immunized with a mixture of different human breast carcinoma cell lines, 30 mAb were selected which reacted more strongly with tumor cells than with (noncancerous) fibroblasts. These mAb were tested for reactivity with additional types of cancerous and noncancerous tissues. Two mAb showed high tumor selectivity, but the corresponding epitopes on individual tumor cells were heterogeneously expressed. The mAb will be evaluated for in vivo applications.</abstract><cop>Basel</cop><cop>Boston, MA</cop><cop>Berlin</cop><pub>Birkhäuser</pub><pmid>2415385</pmid><doi>10.1007/BF01949996</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4754 |
| ispartof | Experientia, 1985-11, Vol.41 (11), p.1377-1381 |
| issn | 0014-4754 1420-9071 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01949996 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - immunology Antibody Specificity antigen (tumor-associated) Antigens, Neoplasm - immunology Biological and medical sciences breast Breast Neoplasms - immunology carcinoma Cell Line cell surface Epitopes - immunology Experimental genital and mammary tumors Female Fibroblasts - immunology Fluorescent Antibody Technique Histocytochemistry Humans Hybridomas - immunology Male Medical sciences Mice Mice, Inbred BALB C monoclonal antibodies Tumors |
| title | Monoclonal antibodies against antigens on breast cancer cells |
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