The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland
Acetylcholine releases calcium from cytoplasmic stores and permits an influx of calcium in salivary acinar cells. The resultant rise in [Ca2+]i causes an increase in potassium permeability which is an important part of the secretory response. We have investigated the effects of 12-O-tetradecanoyl ph...
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| Veröffentlicht in: | Experientia 1995-02, Vol.51 (2), p.110-112 |
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| container_title | Experientia |
| container_volume | 51 |
| creator | Pediani, J D Wilson, S M |
| description | Acetylcholine releases calcium from cytoplasmic stores and permits an influx of calcium in salivary acinar cells. The resultant rise in [Ca2+]i causes an increase in potassium permeability which is an important part of the secretory response. We have investigated the effects of 12-O-tetradecanoyl phorbol-13-acetate, a potent activator of protein kinase C, upon this regulation of potassium permeability in superfused pieces of rat submandibular salivary gland. This compound inhibited the initial [Ca2+]O-independent component of the response of acetylcholine but had no effect upon the subsequent [Ca2+]O-dependent phase. This compound does not, therefore, appear to inhibit receptor-regulated calcium influx. |
| doi_str_mv | 10.1007/BF01929350 |
| format | Article |
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The resultant rise in [Ca2+]i causes an increase in potassium permeability which is an important part of the secretory response. We have investigated the effects of 12-O-tetradecanoyl phorbol-13-acetate, a potent activator of protein kinase C, upon this regulation of potassium permeability in superfused pieces of rat submandibular salivary gland. This compound inhibited the initial [Ca2+]O-independent component of the response of acetylcholine but had no effect upon the subsequent [Ca2+]O-dependent phase. This compound does not, therefore, appear to inhibit receptor-regulated calcium influx.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium - pharmacology</subject><subject>Choline - physiology</subject><subject>Kinetics</subject><subject>Permeability</subject><subject>Potassium - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rubidium Radioisotopes - metabolism</subject><subject>Submandibular Gland - drug effects</subject><subject>Submandibular Gland - metabolism</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLAzEQRoMotVYv3oWchdVJNtlsjlqsCgUv9bxks0kb2W2WJCv03xtp0dMMzPuGmYfQLYEHAiAen1dAJJUlhzM0J4xCIUGQczQHIKxggrNLdBXjF0AJnFQzNBO14JSJOfre7Aw21hqdsLdY4XHnQ-t7bGIyAU-j3-OUEb3zvdubsHUaB7OdepVcHuXI6JOK0U0DHk0YjGpd79IBu2MuqITj1A5q37k2pwLe9rm_RhdW9dHcnOoCfa5eNsu3Yv3x-r58WheaMpIKW9eWMFtRxSmtWmsUrztJaEV5q0nVsU4TWSugpQQKnSVGy07QWlEt87NluUD3x706-BiDsc0Y3KDCoSHQ_Lpr_t1l-O4Ij_lg0_2hJ1nlD5h7apU</recordid><startdate>19950215</startdate><enddate>19950215</enddate><creator>Pediani, J D</creator><creator>Wilson, S M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19950215</creationdate><title>The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland</title><author>Pediani, J D ; Wilson, S M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-f88f14f62a5226bfea58d912625bc16d4dc198a0239020df1ec9d728a2c900333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Calcium - pharmacology</topic><topic>Choline - physiology</topic><topic>Kinetics</topic><topic>Permeability</topic><topic>Potassium - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rubidium Radioisotopes - metabolism</topic><topic>Submandibular Gland - drug effects</topic><topic>Submandibular Gland - metabolism</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pediani, J D</creatorcontrib><creatorcontrib>Wilson, S M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pediani, J D</au><au>Wilson, S M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1995-02-15</date><risdate>1995</risdate><volume>51</volume><issue>2</issue><spage>110</spage><epage>112</epage><pages>110-112</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><abstract>Acetylcholine releases calcium from cytoplasmic stores and permits an influx of calcium in salivary acinar cells. The resultant rise in [Ca2+]i causes an increase in potassium permeability which is an important part of the secretory response. We have investigated the effects of 12-O-tetradecanoyl phorbol-13-acetate, a potent activator of protein kinase C, upon this regulation of potassium permeability in superfused pieces of rat submandibular salivary gland. This compound inhibited the initial [Ca2+]O-independent component of the response of acetylcholine but had no effect upon the subsequent [Ca2+]O-dependent phase. This compound does not, therefore, appear to inhibit receptor-regulated calcium influx.</abstract><cop>Switzerland</cop><pmid>7875247</pmid><doi>10.1007/BF01929350</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4754 |
| ispartof | Experientia, 1995-02, Vol.51 (2), p.110-112 |
| issn | 0014-4754 1420-9071 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01929350 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetylcholine - pharmacology Animals Calcium - metabolism Calcium - pharmacology Choline - physiology Kinetics Permeability Potassium - metabolism Rats Rats, Wistar Rubidium Radioisotopes - metabolism Submandibular Gland - drug effects Submandibular Gland - metabolism Tetradecanoylphorbol Acetate - pharmacology |
| title | The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland |
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