Effects of ovarian steroids on superoxide dismutase activity in the rat brain
The levels of manganese superoxide dismutase (MnSOD) and copper-zinc superoxide dismutase (CuZn-SOD) were determined in appropriate subcellular fractions prepared from whole brain homogenates of cycling and long-term (3 week) ovariectomized (OVX) Wistar rats, and were compared to the levels found in...
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| Veröffentlicht in: | Experientia 1993-01, Vol.49 (1), p.73-75 |
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| creator | PAJOVIC, S NIKEZIC, G MARTINOVIC, J. V |
| description | The levels of manganese superoxide dismutase (MnSOD) and copper-zinc superoxide dismutase (CuZn-SOD) were determined in appropriate subcellular fractions prepared from whole brain homogenates of cycling and long-term (3 week) ovariectomized (OVX) Wistar rats, and were compared to the levels found in corresponding samples prepared from OVX rats treated with progesterone (P) or estradiol 17B-benzoate (EB). The activity of both SODs was steady during the estrous cycle, except at proestrus, when MnSOD activity was elevated significantly. Bilateral ovariectomy resulted three weeks later in an increase of the MnSOD activity even higher than that recorded at proestrus. High post-castration MnSOD activity was lowered profoundly by exogenous P (2 mg) or EB (0.5 micrograms), given s.c. to OVX animals 2 h or 24 h before sacrifice. Neither removal of the ovaries nor the hormone treatments affected the activity of CuZnSOD. These results suggest suppressive effects of ovarian steroids on MnSOD activity in the rat brain. |
| doi_str_mv | 10.1007/bf01928794 |
| format | Article |
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Psychology</topic><topic>Luteinizing Hormone - physiology</topic><topic>Ovariectomy</topic><topic>Progesterone - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAJOVIC, S</creatorcontrib><creatorcontrib>NIKEZIC, G</creatorcontrib><creatorcontrib>MARTINOVIC, J. 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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biochemistry and metabolism Biological and medical sciences Brain - drug effects Brain - enzymology Central nervous system Estradiol - pharmacology Estrus Female Fundamental and applied biological sciences. Psychology Luteinizing Hormone - physiology Ovariectomy Progesterone - pharmacology Rats Rats, Wistar Superoxide Dismutase - metabolism Vertebrates: nervous system and sense organs |
| title | Effects of ovarian steroids on superoxide dismutase activity in the rat brain |
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