Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease
Summary Enzymes involved with the metabolic transformation of xenobiotics have recently been studied in patients with the neurodegenerative diseases, Alzheimer's disease, Parkinson's disease and motor neurone disease. Defects were detected in sulphur pathways and also, in the case of Parki...
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| Veröffentlicht in: | Journal of inherited metabolic disease 1991-07, Vol.14 (4), p.431-435 |
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| container_end_page | 435 |
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| container_issue | 4 |
| container_start_page | 431 |
| container_title | Journal of inherited metabolic disease |
| container_volume | 14 |
| creator | Williams, A. C. Steventon, G. B. Sturman, S. Waring, R. H. |
| description | Summary
Enzymes involved with the metabolic transformation of xenobiotics have recently been studied in patients with the neurodegenerative diseases, Alzheimer's disease, Parkinson's disease and motor neurone disease. Defects were detected in sulphur pathways and also, in the case of Parkinson's disease, in monoamine oxidase B. The possibility exists that the ability to cope safely with endogenous and exogenous substances which have neurotoxic properties is important in the pathogenesis of these diseases. Potentially such individuals could be identified preclinically and these diseases postponed by reduction in the load of toxin or modification of the relevant enzymic activity. |
| doi_str_mv | 10.1007/BF01797916 |
| format | Article |
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Enzymes involved with the metabolic transformation of xenobiotics have recently been studied in patients with the neurodegenerative diseases, Alzheimer's disease, Parkinson's disease and motor neurone disease. Defects were detected in sulphur pathways and also, in the case of Parkinson's disease, in monoamine oxidase B. The possibility exists that the ability to cope safely with endogenous and exogenous substances which have neurotoxic properties is important in the pathogenesis of these diseases. Potentially such individuals could be identified preclinically and these diseases postponed by reduction in the load of toxin or modification of the relevant enzymic activity.</description><identifier>ISSN: 0141-8955</identifier><identifier>EISSN: 1573-2665</identifier><identifier>DOI: 10.1007/BF01797916</identifier><identifier>PMID: 1749211</identifier><identifier>CODEN: JIMDDP</identifier><language>eng</language><publisher>Dordrecht: Kluwer Academic Publishers</publisher><subject>Animals ; Biological and medical sciences ; Humans ; Inactivation, Metabolic - physiology ; Liver - enzymology ; Medical sciences ; Nervous System Diseases - enzymology ; Nervous System Diseases - genetics ; Neurology</subject><ispartof>Journal of inherited metabolic disease, 1991-07, Vol.14 (4), p.431-435</ispartof><rights>1991 SSIEM</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3521-bc3ae1fbe12636a8d11b710e4531214c99de8a9e8f6b042b9fc2ceeccd4c7af63</citedby><cites>FETCH-LOGICAL-c3521-bc3ae1fbe12636a8d11b710e4531214c99de8a9e8f6b042b9fc2ceeccd4c7af63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5367461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1749211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, A. C.</creatorcontrib><creatorcontrib>Steventon, G. B.</creatorcontrib><creatorcontrib>Sturman, S.</creatorcontrib><creatorcontrib>Waring, R. H.</creatorcontrib><title>Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease</title><title>Journal of inherited metabolic disease</title><addtitle>J Inherit Metab Dis</addtitle><description>Summary
Enzymes involved with the metabolic transformation of xenobiotics have recently been studied in patients with the neurodegenerative diseases, Alzheimer's disease, Parkinson's disease and motor neurone disease. Defects were detected in sulphur pathways and also, in the case of Parkinson's disease, in monoamine oxidase B. The possibility exists that the ability to cope safely with endogenous and exogenous substances which have neurotoxic properties is important in the pathogenesis of these diseases. Potentially such individuals could be identified preclinically and these diseases postponed by reduction in the load of toxin or modification of the relevant enzymic activity.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Inactivation, Metabolic - physiology</subject><subject>Liver - enzymology</subject><subject>Medical sciences</subject><subject>Nervous System Diseases - enzymology</subject><subject>Nervous System Diseases - genetics</subject><subject>Neurology</subject><issn>0141-8955</issn><issn>1573-2665</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90D1PxDAMBuAIgY7jY2FHysCEVIibJm1GODg-dIgF5pImDgT1WpSUHsevp6gINiZL9iNbfgk5AHYCjOWn53MGucoVyA0yBZHzJJVSbJIpgwySQgmxTXZifGWMqUKICZlAnqkUYEqerjGg9Z0Oa9rr4HXn24a2jta-x0Cx-VwvMVLf9G3do6Ur371Qi1374Z03o9aNpQ2-h9biMzYYhm6P1PqIOuIe2XK6jrj_U3fJ4_zyYXadLO6vbmZni8RwkUJSGa4RXIWQSi51YQGqHBhmgkMKmVHKYqEVFk5WLEsr5UxqEI2xmcm1k3yXHI97TWhjDOjKt-CXw1slsPI7pfIvpQEfjvjtvVqi_aNjLMP86Geuo9G1C7oxPv4ywWWeyW_GRrbyNa7_OVje3txdsIwD_wJUs3-m</recordid><startdate>199107</startdate><enddate>199107</enddate><creator>Williams, A. C.</creator><creator>Steventon, G. B.</creator><creator>Sturman, S.</creator><creator>Waring, R. H.</creator><general>Kluwer Academic Publishers</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199107</creationdate><title>Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease</title><author>Williams, A. C. ; Steventon, G. B. ; Sturman, S. ; Waring, R. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3521-bc3ae1fbe12636a8d11b710e4531214c99de8a9e8f6b042b9fc2ceeccd4c7af63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Inactivation, Metabolic - physiology</topic><topic>Liver - enzymology</topic><topic>Medical sciences</topic><topic>Nervous System Diseases - enzymology</topic><topic>Nervous System Diseases - genetics</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, A. C.</creatorcontrib><creatorcontrib>Steventon, G. B.</creatorcontrib><creatorcontrib>Sturman, S.</creatorcontrib><creatorcontrib>Waring, R. H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of inherited metabolic disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, A. C.</au><au>Steventon, G. B.</au><au>Sturman, S.</au><au>Waring, R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease</atitle><jtitle>Journal of inherited metabolic disease</jtitle><addtitle>J Inherit Metab Dis</addtitle><date>1991-07</date><risdate>1991</risdate><volume>14</volume><issue>4</issue><spage>431</spage><epage>435</epage><pages>431-435</pages><issn>0141-8955</issn><eissn>1573-2665</eissn><coden>JIMDDP</coden><abstract>Summary
Enzymes involved with the metabolic transformation of xenobiotics have recently been studied in patients with the neurodegenerative diseases, Alzheimer's disease, Parkinson's disease and motor neurone disease. Defects were detected in sulphur pathways and also, in the case of Parkinson's disease, in monoamine oxidase B. The possibility exists that the ability to cope safely with endogenous and exogenous substances which have neurotoxic properties is important in the pathogenesis of these diseases. Potentially such individuals could be identified preclinically and these diseases postponed by reduction in the load of toxin or modification of the relevant enzymic activity.</abstract><cop>Dordrecht</cop><pub>Kluwer Academic Publishers</pub><pmid>1749211</pmid><doi>10.1007/BF01797916</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of inherited metabolic disease, 1991-07, Vol.14 (4), p.431-435 |
| issn | 0141-8955 1573-2665 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01797916 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biological and medical sciences Humans Inactivation, Metabolic - physiology Liver - enzymology Medical sciences Nervous System Diseases - enzymology Nervous System Diseases - genetics Neurology |
| title | Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease |
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