Antimetastatic action and toxicity on healthy tissues of Na[trans-RuCl4(DMSO)Im] in the mouse

The ruthenium-dimethylsulfoxide complex Na(trans-RuCl4(DMSO)Im] was given i.v. to mice bearing MCa mammary carcinoma and its effects on tumor growth and on healthy host tissues were studied by macroscopic examination of primary tumor growth, by survival time, and by histological analysis using light...

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Veröffentlicht in:	Clinical & experimental metastasis 1994-03, Vol.12 (2), p.93-100
Hauptverfasser:	Gagliardi, R, Sava, G, Pacor, S, Mestroni, G, Alessio, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Dimethyl Sulfoxide - analogs & derivatives Dimethyl Sulfoxide - therapeutic use DNA, Neoplasm - biosynthesis Drug Administration Schedule Kidney - drug effects Liver - drug effects Lung - drug effects Lung Neoplasms - pathology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Mice Mice, Inbred CBA Organometallic Compounds - therapeutic use Ruthenium Compounds - therapeutic use
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