Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma
Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants. However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic com...
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| Veröffentlicht in: | Intensive care medicine 1996-08, Vol.22 (8), p.809-812 |
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| container_end_page | 812 |
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| container_issue | 8 |
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| container_title | Intensive care medicine |
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| creator | WAPPLER, F ROEWER, N KÖCHLING, A BRAUNE, H REISSINGER, T SCHULTE AM ESCH, J |
| description | Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants. However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness. MH was treated immediately with dantrolene; the patient recovered within 14 days. Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test. This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma. |
| doi_str_mv | 10.1007/BF01709525 |
| format | Article |
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However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness. MH was treated immediately with dantrolene; the patient recovered within 14 days. Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test. This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. 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Cell therapy and gene therapy ; Biological and medical sciences ; Caffeine ; Cresols - adverse effects ; Dantrolene - therapeutic use ; Diabetic Coma - complications ; Diabetic Ketoacidosis - complications ; Emergency and intensive care: endocrinopathies ; Fever - drug therapy ; Fever - etiology ; Halothane ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Muscle Relaxants, Central - therapeutic use</subject><ispartof>Intensive care medicine, 1996-08, Vol.22 (8), p.809-812</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-a5018778f4609e549b859425a881bba2373e11a394b3d222b470e25b15ee379e3</citedby><cites>FETCH-LOGICAL-c226t-a5018778f4609e549b859425a881bba2373e11a394b3d222b470e25b15ee379e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3197461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8880251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WAPPLER, F</creatorcontrib><creatorcontrib>ROEWER, N</creatorcontrib><creatorcontrib>KÖCHLING, A</creatorcontrib><creatorcontrib>BRAUNE, H</creatorcontrib><creatorcontrib>REISSINGER, T</creatorcontrib><creatorcontrib>SCHULTE AM ESCH, J</creatorcontrib><title>Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants. However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness. MH was treated immediately with dantrolene; the patient recovered within 14 days. Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test. This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Caffeine</subject><subject>Cresols - adverse effects</subject><subject>Dantrolene - therapeutic use</subject><subject>Diabetic Coma - complications</subject><subject>Diabetic Ketoacidosis - complications</subject><subject>Emergency and intensive care: endocrinopathies</subject><subject>Fever - drug therapy</subject><subject>Fever - etiology</subject><subject>Halothane</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Relaxants, Central - therapeutic use</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAURS0EKqGwsCNlYEIK-PkjtkeoKCAqscAcPTsONSRNFbtC_fe0tCrTvdI9usMh5BLoLVCq7h6mFBQ1kskjkoHgrADG9THJKBesEKVgp-Qsxi-6wUoJIzLSWlMmISOv01XbhQUuUt5hGz7_2ny99EOa-6ELmGOMvQuYfJ3_hDTPv33q0YW6T8HldUDrt8X1HZ6Tkwbb6C_2OSYf08f3yXMxe3t6mdzPCsdYmQqUFLRSuhElNV4KY7U0gknUGqxFxhX3AMiNsLxmjFmhqGfSgvSeK-P5mNzsft3Qxzj4ploOocNhXQGttkKqfyEb-GoHL1e28_UB3RvY7Nf7HaPDthlw4UI8YByMEiXwXxFyZuI</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>WAPPLER, F</creator><creator>ROEWER, N</creator><creator>KÖCHLING, A</creator><creator>BRAUNE, H</creator><creator>REISSINGER, T</creator><creator>SCHULTE AM ESCH, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199608</creationdate><title>Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma</title><author>WAPPLER, F ; ROEWER, N ; KÖCHLING, A ; BRAUNE, H ; REISSINGER, T ; SCHULTE AM ESCH, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-a5018778f4609e549b859425a881bba2373e11a394b3d222b470e25b15ee379e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Caffeine</topic><topic>Cresols - adverse effects</topic><topic>Dantrolene - therapeutic use</topic><topic>Diabetic Coma - complications</topic><topic>Diabetic Ketoacidosis - complications</topic><topic>Emergency and intensive care: endocrinopathies</topic><topic>Fever - drug therapy</topic><topic>Fever - etiology</topic><topic>Halothane</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Relaxants, Central - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WAPPLER, F</creatorcontrib><creatorcontrib>ROEWER, N</creatorcontrib><creatorcontrib>KÖCHLING, A</creatorcontrib><creatorcontrib>BRAUNE, H</creatorcontrib><creatorcontrib>REISSINGER, T</creatorcontrib><creatorcontrib>SCHULTE AM ESCH, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WAPPLER, F</au><au>ROEWER, N</au><au>KÖCHLING, A</au><au>BRAUNE, H</au><au>REISSINGER, T</au><au>SCHULTE AM ESCH, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>1996-08</date><risdate>1996</risdate><volume>22</volume><issue>8</issue><spage>809</spage><epage>812</epage><pages>809-812</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants. However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness. MH was treated immediately with dantrolene; the patient recovered within 14 days. Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test. This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>8880251</pmid><doi>10.1007/BF01709525</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 1996-08, Vol.22 (8), p.809-812 |
| issn | 0342-4642 1432-1238 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Caffeine Cresols - adverse effects Dantrolene - therapeutic use Diabetic Coma - complications Diabetic Ketoacidosis - complications Emergency and intensive care: endocrinopathies Fever - drug therapy Fever - etiology Halothane Humans Intensive care medicine Male Medical sciences Muscle Relaxants, Central - therapeutic use |
| title | Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma |
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