Chloroquine poisoning : ventricular fibrillation following 'trivial' overdose in a child
A 13-year-old boy was admitted to hospital 45 min after the ingestion of approximately 750 mg of chloroquine base. A few minutes after gastric lavage with warm water he developed ventricular fibrillation from which he was promptly resuscitated. The plasma concentration of chloroquine was 4.2 mumol/l...
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| Veröffentlicht in: | Intensive care medicine 1992-03, Vol.18 (3), p.170-171 |
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| container_end_page | 171 |
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| container_title | Intensive care medicine |
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| creator | COLLEE, G. G SAMRA, G. S HANSON, G. C |
| description | A 13-year-old boy was admitted to hospital 45 min after the ingestion of approximately 750 mg of chloroquine base. A few minutes after gastric lavage with warm water he developed ventricular fibrillation from which he was promptly resuscitated. The plasma concentration of chloroquine was 4.2 mumol/l; significantly lower than the concentrations previously associated with a fatal outcome in adults. The clinical and electrocardiographic effects of chloroquine poisoning are discussed, and the literature reviewed regarding the role of specific management with diazepam and adrenaline infusions. A period of twenty four hours electrocardiographic (ECG) monitoring and pulse oximetry in an intensive care unit is advocated for all patient with ECG changes following chloroquine overdose. |
| doi_str_mv | 10.1007/BF01709241 |
| format | Article |
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G ; SAMRA, G. S ; HANSON, G. C</creator><creatorcontrib>COLLEE, G. G ; SAMRA, G. S ; HANSON, G. C</creatorcontrib><description>A 13-year-old boy was admitted to hospital 45 min after the ingestion of approximately 750 mg of chloroquine base. A few minutes after gastric lavage with warm water he developed ventricular fibrillation from which he was promptly resuscitated. The plasma concentration of chloroquine was 4.2 mumol/l; significantly lower than the concentrations previously associated with a fatal outcome in adults. The clinical and electrocardiographic effects of chloroquine poisoning are discussed, and the literature reviewed regarding the role of specific management with diazepam and adrenaline infusions. A period of twenty four hours electrocardiographic (ECG) monitoring and pulse oximetry in an intensive care unit is advocated for all patient with ECG changes following chloroquine overdose.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/BF01709241</identifier><identifier>PMID: 1644965</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Cardiopulmonary Resuscitation ; Chloroquine - poisoning ; Drug intoxications. Doping ; Drug Overdose - complications ; Drug Overdose - therapy ; Electrocardiography ; Gastric Lavage ; Humans ; Lidocaine - therapeutic use ; Male ; Medical sciences ; Pharmacology. 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G</creatorcontrib><creatorcontrib>SAMRA, G. S</creatorcontrib><creatorcontrib>HANSON, G. C</creatorcontrib><title>Chloroquine poisoning : ventricular fibrillation following 'trivial' overdose in a child</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>A 13-year-old boy was admitted to hospital 45 min after the ingestion of approximately 750 mg of chloroquine base. A few minutes after gastric lavage with warm water he developed ventricular fibrillation from which he was promptly resuscitated. The plasma concentration of chloroquine was 4.2 mumol/l; significantly lower than the concentrations previously associated with a fatal outcome in adults. The clinical and electrocardiographic effects of chloroquine poisoning are discussed, and the literature reviewed regarding the role of specific management with diazepam and adrenaline infusions. A period of twenty four hours electrocardiographic (ECG) monitoring and pulse oximetry in an intensive care unit is advocated for all patient with ECG changes following chloroquine overdose.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Cardiopulmonary Resuscitation</subject><subject>Chloroquine - poisoning</subject><subject>Drug intoxications. Doping</subject><subject>Drug Overdose - complications</subject><subject>Drug Overdose - therapy</subject><subject>Electrocardiography</subject><subject>Gastric Lavage</subject><subject>Humans</subject><subject>Lidocaine - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Ventricular Fibrillation - chemically induced</subject><subject>Ventricular Fibrillation - diagnosis</subject><subject>Ventricular Fibrillation - therapy</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LAzEQBuAgSq3Vi3chB6EgrGaSbLbrrRarQsGLgrclmw8bSZOatBX_vVta7FwGZh6G4UXoEsgtEFLdPUwJVKSmHI5QHzijBVA2OkZ9wjgtuOD0FJ3l_EU6JkrooR4IzmtR9tHHZO5jit9rFwxeRpdjcOET3-ONCavk1NrLhK1rk_NerlwM2Ebv488WDTuwcdIPcdyYpGM22AUssZo7r8_RiZU-m4t9H6D36ePb5LmYvT69TMazQjGAVaGqtgTS_cIqZpiojZCCUK2p0t2YWlFLzZWWNW8BjDSMQC0s06Kiwo4YYwN0s7urUsw5Gdssk1vI9NsAabbpNId0Ony1w8t1uzD6QHdxdPvr_V5mJb1NMiiX_1nJRqIr9gdhzGvs</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>COLLEE, G. G</creator><creator>SAMRA, G. S</creator><creator>HANSON, G. 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Doping</topic><topic>Drug Overdose - complications</topic><topic>Drug Overdose - therapy</topic><topic>Electrocardiography</topic><topic>Gastric Lavage</topic><topic>Humans</topic><topic>Lidocaine - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Ventricular Fibrillation - chemically induced</topic><topic>Ventricular Fibrillation - diagnosis</topic><topic>Ventricular Fibrillation - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COLLEE, G. G</creatorcontrib><creatorcontrib>SAMRA, G. S</creatorcontrib><creatorcontrib>HANSON, G. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chloroquine poisoning : ventricular fibrillation following 'trivial' overdose in a child</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>1992-03</date><risdate>1992</risdate><volume>18</volume><issue>3</issue><spage>170</spage><epage>171</epage><pages>170-171</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>A 13-year-old boy was admitted to hospital 45 min after the ingestion of approximately 750 mg of chloroquine base. A few minutes after gastric lavage with warm water he developed ventricular fibrillation from which he was promptly resuscitated. The plasma concentration of chloroquine was 4.2 mumol/l; significantly lower than the concentrations previously associated with a fatal outcome in adults. The clinical and electrocardiographic effects of chloroquine poisoning are discussed, and the literature reviewed regarding the role of specific management with diazepam and adrenaline infusions. A period of twenty four hours electrocardiographic (ECG) monitoring and pulse oximetry in an intensive care unit is advocated for all patient with ECG changes following chloroquine overdose.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>1644965</pmid><doi>10.1007/BF01709241</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 1992-03, Vol.18 (3), p.170-171 |
| issn | 0342-4642 1432-1238 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Biological and medical sciences Cardiopulmonary Resuscitation Chloroquine - poisoning Drug intoxications. Doping Drug Overdose - complications Drug Overdose - therapy Electrocardiography Gastric Lavage Humans Lidocaine - therapeutic use Male Medical sciences Pharmacology. Drug treatments Ventricular Fibrillation - chemically induced Ventricular Fibrillation - diagnosis Ventricular Fibrillation - therapy |
| title | Chloroquine poisoning : ventricular fibrillation following 'trivial' overdose in a child |
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