Sex and age mortality responses in zinc acetate-treated mice
In regard to trace metal treatment or exposure, a number of variables are known to affect the expression of toxicity concerning its time course and degree. For example, known variables are route of administration, anionic component of the test substance, and sex and age of the recipient animal. Conc...
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| Veröffentlicht in: | Bull. Environ. Contam. Toxicol.; (United States) 1987-07, Vol.39 (1), p.156-161 |
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| container_title | Bull. Environ. Contam. Toxicol.; (United States) |
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| creator | HOGAN, G. R COLE, B. S LOVELACE, J. M |
| description | In regard to trace metal treatment or exposure, a number of variables are known to affect the expression of toxicity concerning its time course and degree. For example, known variables are route of administration, anionic component of the test substance, and sex and age of the recipient animal. Concerning the latter, little, if any, data have been reported dealing with sex- and age-related responses to excess zinc in mammalian systems. The primary purpose of the short communication presented here focuses on the determination of median lethal dose in sexually immature, i.e., juvenile, and adult female and male mice following a single zinc acetate insult. In addition, variation of lethality responses was examined with the age and sex groups to a divided treatment of a lethal dosage of zinc acetate, the injections of which were separated by various intervals. |
| doi_str_mv | 10.1007/BF01691804 |
| format | Article |
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In addition, variation of lethality responses was examined with the age and sex groups to a divided treatment of a lethal dosage of zinc acetate, the injections of which were separated by various intervals.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/BF01691804</identifier><identifier>PMID: 3607314</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ABDOMEN ; ACETATES ; Acetates - toxicity ; Acetic Acid ; AGE DEPENDENCE ; Aging ; ANIMALS ; Biological and medical sciences ; BLOOD VESSELS ; BODY ; BODY AREAS ; CARBOXYLIC ACID SALTS ; CARDIOVASCULAR SYSTEM ; Chemical and industrial products toxicology. Toxic occupational diseases ; DOSES ; Female ; Lethal Dose 50 ; LETHAL DOSES ; Male ; MAMMALS ; Medical sciences ; Metals and various inorganic compounds ; MICE ; Mice, Inbred ICR ; MORTALITY ; NECROSIS ; ORGANS ; PATHOLOGICAL CHANGES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RODENTS ; SEX DEPENDENCE ; Sex Factors ; Toxicology ; VASODILATION ; VERTEBRATES ; ZINC COMPOUNDS</subject><ispartof>Bull. Environ. Contam. 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S</creatorcontrib><creatorcontrib>LOVELACE, J. M</creatorcontrib><creatorcontrib>East Texas State Univ., Commerce</creatorcontrib><title>Sex and age mortality responses in zinc acetate-treated mice</title><title>Bull. Environ. Contam. Toxicol.; (United States)</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>In regard to trace metal treatment or exposure, a number of variables are known to affect the expression of toxicity concerning its time course and degree. For example, known variables are route of administration, anionic component of the test substance, and sex and age of the recipient animal. Concerning the latter, little, if any, data have been reported dealing with sex- and age-related responses to excess zinc in mammalian systems. The primary purpose of the short communication presented here focuses on the determination of median lethal dose in sexually immature, i.e., juvenile, and adult female and male mice following a single zinc acetate insult. In addition, variation of lethality responses was examined with the age and sex groups to a divided treatment of a lethal dosage of zinc acetate, the injections of which were separated by various intervals.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ABDOMEN</subject><subject>ACETATES</subject><subject>Acetates - toxicity</subject><subject>Acetic Acid</subject><subject>AGE DEPENDENCE</subject><subject>Aging</subject><subject>ANIMALS</subject><subject>Biological and medical sciences</subject><subject>BLOOD VESSELS</subject><subject>BODY</subject><subject>BODY AREAS</subject><subject>CARBOXYLIC ACID SALTS</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>DOSES</subject><subject>Female</subject><subject>Lethal Dose 50</subject><subject>LETHAL DOSES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>MICE</subject><subject>Mice, Inbred ICR</subject><subject>MORTALITY</subject><subject>NECROSIS</subject><subject>ORGANS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RODENTS</subject><subject>SEX DEPENDENCE</subject><subject>Sex Factors</subject><subject>Toxicology</subject><subject>VASODILATION</subject><subject>VERTEBRATES</subject><subject>ZINC COMPOUNDS</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEURYMotVY37oUgroTRl2TyMeBGi1Wh4EJdDy-ZjEbamZJEsP56R1rq6i7O4S4OIacMrhiAvr6bAVMVM1DukTErBS_AAOyTMQy0KI1ih-QopU8AJg3nIzISCrRg5ZjcvPhvil1D8d3TZR8zLkJe0-jTqu-STzR09Cd0jqLzGbMvcvTDNHQZnD8mBy0ukj_Z7oS8ze5fp4_F_PnhaXo7LxyvdC6YUpaLFhUaA04ZJqUyiLpBK7h0WBmmbWNUo7mprHLS2qZSHCvQ3AJXYkLON799yqFOLmTvPlzfdd7lWkoJpeGDdLmRXOxTir6tVzEsMa5rBvVfpvo_0yCfbeTVl136Zqduuwz8YssxOVy0ETsX0k7TQmvDQfwCdr5spg</recordid><startdate>19870701</startdate><enddate>19870701</enddate><creator>HOGAN, G. R</creator><creator>COLE, B. S</creator><creator>LOVELACE, J. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c297t-166b23fa6a880c6815568aa7dab325ca9817bd86d7289b6c5bbd962a9072b0263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ABDOMEN</topic><topic>ACETATES</topic><topic>Acetates - toxicity</topic><topic>Acetic Acid</topic><topic>AGE DEPENDENCE</topic><topic>Aging</topic><topic>ANIMALS</topic><topic>Biological and medical sciences</topic><topic>BLOOD VESSELS</topic><topic>BODY</topic><topic>BODY AREAS</topic><topic>CARBOXYLIC ACID SALTS</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>DOSES</topic><topic>Female</topic><topic>Lethal Dose 50</topic><topic>LETHAL DOSES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>MICE</topic><topic>Mice, Inbred ICR</topic><topic>MORTALITY</topic><topic>NECROSIS</topic><topic>ORGANS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RODENTS</topic><topic>SEX DEPENDENCE</topic><topic>Sex Factors</topic><topic>Toxicology</topic><topic>VASODILATION</topic><topic>VERTEBRATES</topic><topic>ZINC COMPOUNDS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOGAN, G. R</creatorcontrib><creatorcontrib>COLE, B. S</creatorcontrib><creatorcontrib>LOVELACE, J. 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Toxicol.; (United States)</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1987-07-01</date><risdate>1987</risdate><volume>39</volume><issue>1</issue><spage>156</spage><epage>161</epage><pages>156-161</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><abstract>In regard to trace metal treatment or exposure, a number of variables are known to affect the expression of toxicity concerning its time course and degree. For example, known variables are route of administration, anionic component of the test substance, and sex and age of the recipient animal. Concerning the latter, little, if any, data have been reported dealing with sex- and age-related responses to excess zinc in mammalian systems. The primary purpose of the short communication presented here focuses on the determination of median lethal dose in sexually immature, i.e., juvenile, and adult female and male mice following a single zinc acetate insult. In addition, variation of lethality responses was examined with the age and sex groups to a divided treatment of a lethal dosage of zinc acetate, the injections of which were separated by various intervals.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>3607314</pmid><doi>10.1007/BF01691804</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4861 |
| ispartof | Bull. Environ. Contam. Toxicol.; (United States), 1987-07, Vol.39 (1), p.156-161 |
| issn | 0007-4861 1432-0800 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01691804 |
| source | MEDLINE; Springer LINK 全文期刊数据库 |
| subjects | 560300 - Chemicals Metabolism & Toxicology ABDOMEN ACETATES Acetates - toxicity Acetic Acid AGE DEPENDENCE Aging ANIMALS Biological and medical sciences BLOOD VESSELS BODY BODY AREAS CARBOXYLIC ACID SALTS CARDIOVASCULAR SYSTEM Chemical and industrial products toxicology. Toxic occupational diseases DOSES Female Lethal Dose 50 LETHAL DOSES Male MAMMALS Medical sciences Metals and various inorganic compounds MICE Mice, Inbred ICR MORTALITY NECROSIS ORGANS PATHOLOGICAL CHANGES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RODENTS SEX DEPENDENCE Sex Factors Toxicology VASODILATION VERTEBRATES ZINC COMPOUNDS |
| title | Sex and age mortality responses in zinc acetate-treated mice |
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