Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter
Mecillinam, ampicillin and combinations of the two were tested against Enterobacteriaceae by traditional agar dilution and under in vitro conditions simulating in vivo pharmacokinetics. Synergy was demonstrated by agar dilution in 30% of the strains. At simulated in vivo conditions, synergy between...
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| Veröffentlicht in: | Infection 1981-01, Vol.9 (6), p.290-295 |
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| container_title | Infection |
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| creator | Fuglesang, J E Bergan, T Bielecki, T Naterstad, A Namork, E |
| description | Mecillinam, ampicillin and combinations of the two were tested against Enterobacteriaceae by traditional agar dilution and under in vitro conditions simulating in vivo pharmacokinetics. Synergy was demonstrated by agar dilution in 30% of the strains. At simulated in vivo conditions, synergy between ampicillin and mecillinam was detected in a high osmolality medium, but not when the osmolality of the medium was low. The bactericidal effect was detected with mecillinam after one hour, while that of ampicillin or the combination was detected after 15 min. Changed bacterial morphology was observed by electron microscopy. Mecillinam produced ovoid spherical cell structures whereas combinations of the two drugs produced larger bacterial spheres. |
| doi_str_mv | 10.1007/BF01640994 |
| format | Article |
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Synergy was demonstrated by agar dilution in 30% of the strains. At simulated in vivo conditions, synergy between ampicillin and mecillinam was detected in a high osmolality medium, but not when the osmolality of the medium was low. The bactericidal effect was detected with mecillinam after one hour, while that of ampicillin or the combination was detected after 15 min. Changed bacterial morphology was observed by electron microscopy. Mecillinam produced ovoid spherical cell structures whereas combinations of the two drugs produced larger bacterial spheres.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/BF01640994</identifier><identifier>PMID: 6277795</identifier><language>eng</language><publisher>Germany</publisher><subject>Acinetobacter - drug effects ; Acinetobacter - metabolism ; Acinetobacter - ultrastructure ; Amdinocillin - administration & dosage ; Amdinocillin - pharmacology ; Ampicillin - administration & dosage ; Ampicillin - pharmacology ; Drug Combinations ; Drug Synergism ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - metabolism ; Enterobacteriaceae - ultrastructure ; Penicillanic Acid - administration & dosage ; Pseudomonas - drug effects ; Pseudomonas - metabolism ; Pseudomonas - ultrastructure</subject><ispartof>Infection, 1981-01, Vol.9 (6), p.290-295</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-19d4132ba86b1374506356dc1b7ae632ded1360cf4b767ba2a40ff75afad56173</citedby><cites>FETCH-LOGICAL-c282t-19d4132ba86b1374506356dc1b7ae632ded1360cf4b767ba2a40ff75afad56173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6277795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuglesang, J E</creatorcontrib><creatorcontrib>Bergan, T</creatorcontrib><creatorcontrib>Bielecki, T</creatorcontrib><creatorcontrib>Naterstad, A</creatorcontrib><creatorcontrib>Namork, E</creatorcontrib><title>Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter</title><title>Infection</title><addtitle>Infection</addtitle><description>Mecillinam, ampicillin and combinations of the two were tested against Enterobacteriaceae by traditional agar dilution and under in vitro conditions simulating in vivo pharmacokinetics. Synergy was demonstrated by agar dilution in 30% of the strains. At simulated in vivo conditions, synergy between ampicillin and mecillinam was detected in a high osmolality medium, but not when the osmolality of the medium was low. The bactericidal effect was detected with mecillinam after one hour, while that of ampicillin or the combination was detected after 15 min. Changed bacterial morphology was observed by electron microscopy. Mecillinam produced ovoid spherical cell structures whereas combinations of the two drugs produced larger bacterial spheres.</description><subject>Acinetobacter - drug effects</subject><subject>Acinetobacter - metabolism</subject><subject>Acinetobacter - ultrastructure</subject><subject>Amdinocillin - administration & dosage</subject><subject>Amdinocillin - pharmacology</subject><subject>Ampicillin - administration & dosage</subject><subject>Ampicillin - pharmacology</subject><subject>Drug Combinations</subject><subject>Drug Synergism</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - metabolism</subject><subject>Enterobacteriaceae - ultrastructure</subject><subject>Penicillanic Acid - administration & dosage</subject><subject>Pseudomonas - drug effects</subject><subject>Pseudomonas - metabolism</subject><subject>Pseudomonas - ultrastructure</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAt7FmNns5vd5lhLq0JBD3oOsx_R1WRTsqnQH-F_NrVBTzPv8PAMvIRcMrhlAGp6twImBeS5OCJjJnieQK74MRkDB0hmLJWn5CzGDwDIcqFGZCRTpVSejcn3Y3j32ndNu6NoOv_lu34Jluo-udYbb7Ginz64zptIm5LWzviq8gHrKdYbfwjUNLXub51vQqT4hj7Eji5Dr2gGExqH7oY-R7e1Td0EjL9_5mbvHqBzclJiFd3FMCfkdbV8WTwk66f7x8V8nZh0lnYJy61gPNU4k5pxJTKQPJPWMK3QSZ5aZxmXYEqhlVQaUxRQlirDEm0mmeITcn3wmraJsXVlsWl9je2uYFDsKy3-K-3hqwO82era2T906JD_AKMUdMw</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Fuglesang, J E</creator><creator>Bergan, T</creator><creator>Bielecki, T</creator><creator>Naterstad, A</creator><creator>Namork, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19810101</creationdate><title>Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter</title><author>Fuglesang, J E ; Bergan, T ; Bielecki, T ; Naterstad, A ; Namork, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-19d4132ba86b1374506356dc1b7ae632ded1360cf4b767ba2a40ff75afad56173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Acinetobacter - drug effects</topic><topic>Acinetobacter - metabolism</topic><topic>Acinetobacter - ultrastructure</topic><topic>Amdinocillin - administration & dosage</topic><topic>Amdinocillin - pharmacology</topic><topic>Ampicillin - administration & dosage</topic><topic>Ampicillin - pharmacology</topic><topic>Drug Combinations</topic><topic>Drug Synergism</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Enterobacteriaceae - metabolism</topic><topic>Enterobacteriaceae - ultrastructure</topic><topic>Penicillanic Acid - administration & dosage</topic><topic>Pseudomonas - drug effects</topic><topic>Pseudomonas - metabolism</topic><topic>Pseudomonas - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuglesang, J E</creatorcontrib><creatorcontrib>Bergan, T</creatorcontrib><creatorcontrib>Bielecki, T</creatorcontrib><creatorcontrib>Naterstad, A</creatorcontrib><creatorcontrib>Namork, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuglesang, J E</au><au>Bergan, T</au><au>Bielecki, T</au><au>Naterstad, A</au><au>Namork, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>9</volume><issue>6</issue><spage>290</spage><epage>295</epage><pages>290-295</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>Mecillinam, ampicillin and combinations of the two were tested against Enterobacteriaceae by traditional agar dilution and under in vitro conditions simulating in vivo pharmacokinetics. Synergy was demonstrated by agar dilution in 30% of the strains. At simulated in vivo conditions, synergy between ampicillin and mecillinam was detected in a high osmolality medium, but not when the osmolality of the medium was low. The bactericidal effect was detected with mecillinam after one hour, while that of ampicillin or the combination was detected after 15 min. Changed bacterial morphology was observed by electron microscopy. Mecillinam produced ovoid spherical cell structures whereas combinations of the two drugs produced larger bacterial spheres.</abstract><cop>Germany</cop><pmid>6277795</pmid><doi>10.1007/BF01640994</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 1981-01, Vol.9 (6), p.290-295 |
| issn | 0300-8126 1439-0973 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Acinetobacter - drug effects Acinetobacter - metabolism Acinetobacter - ultrastructure Amdinocillin - administration & dosage Amdinocillin - pharmacology Ampicillin - administration & dosage Ampicillin - pharmacology Drug Combinations Drug Synergism Enterobacteriaceae - drug effects Enterobacteriaceae - metabolism Enterobacteriaceae - ultrastructure Penicillanic Acid - administration & dosage Pseudomonas - drug effects Pseudomonas - metabolism Pseudomonas - ultrastructure |
| title | Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter |
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