Investigation into the immunological effects of miltefosine, a new anticancer agent under development

Miltefosine is the prototype of alkylphosphocholines, a new class of anticancer agents related to alkyl-lysophospholipids. These agents were considered to possess potent immunomodulatory properties. Miltefosine was highly active against the human KB tumour xenograft in nude mice, leading to growth i...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 1991-01, Vol.117 (5), p.403-408
Hauptverfasser:	HILGARD, P, KAMPHERM, E, NOLAN, L, POHL, J, REISSMANN, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - drug effects Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Female General aspects Humans Immunity, Cellular - drug effects Macrophages - drug effects Macrophages - immunology Male Medical sciences Mice Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Phagocytosis - drug effects Pharmacology. Drug treatments Phosphorylcholine - analogs & derivatives Phosphorylcholine - immunology Phosphorylcholine - toxicity Rats Rats, Inbred Strains Spleen - cytology Spleen - drug effects Spleen - immunology Tumor Cells, Cultured
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