Purine mutants of mammalian cell lines: III. Control of purine biosynthesis in adenine phosphoribosyl transferase mutants of CHO cells

Spontaneous and mutagen-induced 2,6-diaminopurine-resistant mutants of Chinese hamster ovary (CHO-K1) cells were isolated. Such mutants fell into two classes: spontaneous and ethylmethane-sulfonate-induced mutants had approximately 5% wild-type adenine phosphoribosyl transferase (APRT) activity, whe...

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Veröffentlicht in:	Somatic Cell Genetics 1977-03, Vol.3 (2), p.195-206
Hauptverfasser:	Taylor, M W, Pipkorn, J H, Tokito, M K, Pozzatti, Jr, R O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Phosphoribosyltransferase - genetics Cell Line Drug Resistance Hypoxanthine Phosphoribosyltransferase - genetics Mutagens Mutation Nitrogen Mustard Compounds - pharmacology Pentosyltransferases - genetics Purines - biosynthesis
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