Lethal intoxication with diphenhydramine. Report of a case with analytical follow-up

A fatal monointoxication with diphenhydramine in a male 28 year old is reported. The patient went into hyperpyrexia and tachycardia and died from sudden cardiac arrest. Hemorrhagic pulmonary edema and renal shock were the most prominent pathomorphological findings. At the time of death, the concentr...

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Veröffentlicht in:Archives of toxicology 1983-05, Vol.53 (1), p.33-39
Hauptverfasser: Hausmann, E, Wewer, H, Wellhöner, H H, Weller, J P
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creator Hausmann, E
Wewer, H
Wellhöner, H H
Weller, J P
description A fatal monointoxication with diphenhydramine in a male 28 year old is reported. The patient went into hyperpyrexia and tachycardia and died from sudden cardiac arrest. Hemorrhagic pulmonary edema and renal shock were the most prominent pathomorphological findings. At the time of death, the concentration of diphenhydramine was 5 mg/l plasma and was particularly high in the lungs (55 mg/kg) and kidneys (50 mg/kg).
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Adult
Chromatography, Gas
Diphenhydramine - analysis
Diphenhydramine - poisoning
Follow-Up Studies
Gas Chromatography-Mass Spectrometry
Humans
Male
title Lethal intoxication with diphenhydramine. Report of a case with analytical follow-up
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