Intracarotid infusion of ACNU and BCNU as adjuvant therapy of malignant gliomas: clinical aspects and critical considerations
Thirty patients with malignant gliomas were treated by operation, radiotherapy and additional intracarotid infusions of ACNU and BCNU. Positive results were obtained in the treatment of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multif...
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| Veröffentlicht in: | Acta neurochirurgica 1987-01, Vol.85 (3-4), p.128-137 |
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| container_end_page | 137 |
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| container_issue | 3-4 |
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| container_title | Acta neurochirurgica |
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| creator | PAPAVERO, L LOEW, F JAKSCHE, H |
| description | Thirty patients with malignant gliomas were treated by operation, radiotherapy and additional intracarotid infusions of ACNU and BCNU. Positive results were obtained in the treatment of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multiforme were disappointing: neither survival time nor quality of life had been significantly improved. The protective effect of phenobarbitone against systemic toxicity by ACNU was not always confirmed in this study. Based on literature reports and our own experience the indications, technical aspects, unexpected complications and results of this therapeutic approach are discussed. |
| doi_str_mv | 10.1007/BF01456109 |
| format | Article |
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Positive results were obtained in the treatment of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multiforme were disappointing: neither survival time nor quality of life had been significantly improved. The protective effect of phenobarbitone against systemic toxicity by ACNU was not always confirmed in this study. Based on literature reports and our own experience the indications, technical aspects, unexpected complications and results of this therapeutic approach are discussed.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/BF01456109</identifier><identifier>PMID: 3035882</identifier><identifier>CODEN: ACNUA5</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Antineoplastic agents ; Astrocytoma - drug therapy ; Biological and medical sciences ; Brain Neoplasms - drug therapy ; Carmustine - therapeutic use ; Carotid Arteries ; Chemotherapy ; Combined Modality Therapy ; Follow-Up Studies ; Glioblastoma - drug therapy ; Glioma - drug therapy ; Humans ; Infusions, Intra-Arterial ; Medical sciences ; Neoplasm Recurrence, Local ; Nimustine ; Nitrosourea Compounds - therapeutic use ; Oligodendroglioma - drug therapy ; Pharmacology. 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Positive results were obtained in the treatment of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multiforme were disappointing: neither survival time nor quality of life had been significantly improved. The protective effect of phenobarbitone against systemic toxicity by ACNU was not always confirmed in this study. Based on literature reports and our own experience the indications, technical aspects, unexpected complications and results of this therapeutic approach are discussed.</description><subject>Antineoplastic agents</subject><subject>Astrocytoma - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Carmustine - therapeutic use</subject><subject>Carotid Arteries</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>Follow-Up Studies</subject><subject>Glioblastoma - drug therapy</subject><subject>Glioma - drug therapy</subject><subject>Humans</subject><subject>Infusions, Intra-Arterial</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local</subject><subject>Nimustine</subject><subject>Nitrosourea Compounds - therapeutic use</subject><subject>Oligodendroglioma - drug therapy</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAPAVERO, L</creatorcontrib><creatorcontrib>LOEW, F</creatorcontrib><creatorcontrib>JAKSCHE, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PAPAVERO, L</au><au>LOEW, F</au><au>JAKSCHE, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracarotid infusion of ACNU and BCNU as adjuvant therapy of malignant gliomas: clinical aspects and critical considerations</atitle><jtitle>Acta neurochirurgica</jtitle><addtitle>Acta Neurochir (Wien)</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>85</volume><issue>3-4</issue><spage>128</spage><epage>137</epage><pages>128-137</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><coden>ACNUA5</coden><abstract>Thirty patients with malignant gliomas were treated by operation, radiotherapy and additional intracarotid infusions of ACNU and BCNU. Positive results were obtained in the treatment of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multiforme were disappointing: neither survival time nor quality of life had been significantly improved. The protective effect of phenobarbitone against systemic toxicity by ACNU was not always confirmed in this study. Based on literature reports and our own experience the indications, technical aspects, unexpected complications and results of this therapeutic approach are discussed.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>3035882</pmid><doi>10.1007/BF01456109</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6268 |
| ispartof | Acta neurochirurgica, 1987-01, Vol.85 (3-4), p.128-137 |
| issn | 0001-6268 0942-0940 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01456109 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antineoplastic agents Astrocytoma - drug therapy Biological and medical sciences Brain Neoplasms - drug therapy Carmustine - therapeutic use Carotid Arteries Chemotherapy Combined Modality Therapy Follow-Up Studies Glioblastoma - drug therapy Glioma - drug therapy Humans Infusions, Intra-Arterial Medical sciences Neoplasm Recurrence, Local Nimustine Nitrosourea Compounds - therapeutic use Oligodendroglioma - drug therapy Pharmacology. Drug treatments |
| title | Intracarotid infusion of ACNU and BCNU as adjuvant therapy of malignant gliomas: clinical aspects and critical considerations |
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