Role of locally generated prostaglandins in adaptive gastric cytoprotection

This study was designed to determine the role of mucosal generation of prostaglandins (PGs) in the ability of mild irritants (20% ethanol or 5% NaCl) to protect against the formation of mucosal lesions caused by necrotizing agents (100% ethanol or 25% NaCl) or acidified aspirin (ASA). Mild irritants...

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Veröffentlicht in:	Digestive diseases and sciences 1982-11, Vol.27 (11), p.967-971
Hauptverfasser:	Konturek, S J, Brzozowski, T, Piastucki, I, Radecki, T, Dembiński, A, Dembińska-Kieć, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin Epoprostenol - metabolism Epoprostenol - therapeutic use Ethanol Female Gastric Mucosa - drug effects Gastric Mucosa - metabolism Irritants - pharmacology Male Prostaglandins - metabolism Prostaglandins - therapeutic use Prostaglandins E - metabolism Prostaglandins E - therapeutic use Rats Rats, Inbred Strains Sodium Chloride Stomach Diseases - chemically induced Stomach Diseases - prevention & control
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