Influence of prednisolone on gastric alkaline response in rat stomach. A possible explanation for steroid-induced gastric lesion

Exposure of the rat stomach for 10 min to 1 M NaCl produced an increase of luminal pH (alkaline response) with a concomitant reduction of the transmucosal potential difference (PD) and an increased generation of mucosal prostaglandins of E2 and 6-keto F1 alpha. Prednisolone (3-50 mg/kg), given subcu...

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Veröffentlicht in:	Digestive diseases and sciences 1985-12, Vol.30 (12), p.1166-1173
Hauptverfasser:	NOBUHARA, Y, UEKI, S, TAKEUCHI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	16,16-Dimethylprostaglandin E2 - pharmacology 6-Ketoprostaglandin F1 alpha - metabolism Animals Biological and medical sciences Cycloheximide - pharmacology Dinoprostone Drug toxicity and drugs side effects treatment Gastric Acid - metabolism Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Hydrogen-Ion Concentration Male Medical sciences Membrane Potentials - drug effects Perfusion Pharmacology. Drug treatments Prednisolone - adverse effects Prednisolone - antagonists & inhibitors Prednisolone - pharmacology Prostaglandins E - metabolism Rats Rats, Inbred Strains Sodium Chloride - metabolism Stomach Diseases - chemically induced Toxicity: digestive system
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