Striatal and extrastriatal imaging of dopamine D2 receptors in the living human brain with [123I]epidepride single-photon emission tomography
The iodine-123 labelled ligand benzamide epidepride was evaluated as a probe for in vivo imaging of striatal and extrastriatal dopamine D2 receptor sites in the human brain. Four healthy males were imaged with a high-resolution single-photon emission tomography scanner. Striatal radioactivity peaked...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 1997-05, Vol.24 (5), p.483-487 |
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| container_title | European Journal of Nuclear Medicine |
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| creator | KUIKKA, J. T AKERMAN, K. K HILTUNEN, J BERGSTRÖM, K. A RÄSÄNEN, P VANNINEN, E HALLDIN, C TIIHONEN, J |
| description | The iodine-123 labelled ligand benzamide epidepride was evaluated as a probe for in vivo imaging of striatal and extrastriatal dopamine D2 receptor sites in the human brain. Four healthy males were imaged with a high-resolution single-photon emission tomography scanner. Striatal radioactivity peaked at 3 h after injection. The specific binding in the striatum was 0.91+/-0.03 at 3 h and this ratio steadily increased with time. Extrastriatal radioactivity was highest in the thalamus, in the midbrain and in the temporal cortex, and peaked at 45-60 min after injection of tracer. A smaller amount of radioactivity was found in the parietal, frontal and occipital cortices. Two radioactive metabolites were observed, of which one was more lipophilic than the parent compound. The radiation burden to the patient was 0.035 mSv/MBq (effective dose equivalent). The preliminary results showed that [123I]epidepride can be used for imaging striatal and extrastriatal dopamine D2 receptor sites in the living human brain. |
| doi_str_mv | 10.1007/BF01267678 |
| format | Article |
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Two radioactive metabolites were observed, of which one was more lipophilic than the parent compound. The radiation burden to the patient was 0.035 mSv/MBq (effective dose equivalent). 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The specific binding in the striatum was 0.91+/-0.03 at 3 h and this ratio steadily increased with time. Extrastriatal radioactivity was highest in the thalamus, in the midbrain and in the temporal cortex, and peaked at 45-60 min after injection of tracer. A smaller amount of radioactivity was found in the parietal, frontal and occipital cortices. Two radioactive metabolites were observed, of which one was more lipophilic than the parent compound. The radiation burden to the patient was 0.035 mSv/MBq (effective dose equivalent). 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A ; RÄSÄNEN, P ; VANNINEN, E ; HALLDIN, C ; TIIHONEN, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1587-962cf9a64771858995b98ea7d125d28467b4fcdc315fff0fcdaecac20b0c95aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Benzamides - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Pyrrolidines - pharmacokinetics</topic><topic>Radionuclide investigations</topic><topic>Receptors, Dopamine D2 - analysis</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUIKKA, J. T</creatorcontrib><creatorcontrib>AKERMAN, K. K</creatorcontrib><creatorcontrib>HILTUNEN, J</creatorcontrib><creatorcontrib>BERGSTRÖM, K. A</creatorcontrib><creatorcontrib>RÄSÄNEN, P</creatorcontrib><creatorcontrib>VANNINEN, E</creatorcontrib><creatorcontrib>HALLDIN, C</creatorcontrib><creatorcontrib>TIIHONEN, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUIKKA, J. T</au><au>AKERMAN, K. K</au><au>HILTUNEN, J</au><au>BERGSTRÖM, K. A</au><au>RÄSÄNEN, P</au><au>VANNINEN, E</au><au>HALLDIN, C</au><au>TIIHONEN, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Striatal and extrastriatal imaging of dopamine D2 receptors in the living human brain with [123I]epidepride single-photon emission tomography</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1997-05</date><risdate>1997</risdate><volume>24</volume><issue>5</issue><spage>483</spage><epage>487</epage><pages>483-487</pages><issn>0340-6997</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>The iodine-123 labelled ligand benzamide epidepride was evaluated as a probe for in vivo imaging of striatal and extrastriatal dopamine D2 receptor sites in the human brain. Four healthy males were imaged with a high-resolution single-photon emission tomography scanner. Striatal radioactivity peaked at 3 h after injection. The specific binding in the striatum was 0.91+/-0.03 at 3 h and this ratio steadily increased with time. Extrastriatal radioactivity was highest in the thalamus, in the midbrain and in the temporal cortex, and peaked at 45-60 min after injection of tracer. A smaller amount of radioactivity was found in the parietal, frontal and occipital cortices. Two radioactive metabolites were observed, of which one was more lipophilic than the parent compound. The radiation burden to the patient was 0.035 mSv/MBq (effective dose equivalent). The preliminary results showed that [123I]epidepride can be used for imaging striatal and extrastriatal dopamine D2 receptor sites in the living human brain.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9142727</pmid><doi>10.1007/BF01267678</doi><tpages>5</tpages></addata></record> |
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| ispartof | European Journal of Nuclear Medicine, 1997-05, Vol.24 (5), p.483-487 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Benzamides - pharmacokinetics Biological and medical sciences Brain - diagnostic imaging Corpus Striatum - diagnostic imaging Humans Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Male Medical sciences Middle Aged Nervous system Pyrrolidines - pharmacokinetics Radionuclide investigations Receptors, Dopamine D2 - analysis Tomography, Emission-Computed, Single-Photon - methods |
| title | Striatal and extrastriatal imaging of dopamine D2 receptors in the living human brain with [123I]epidepride single-photon emission tomography |
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