Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat
The effects of intraperitoneally administered baclofen on behavior and electrocorticograms (ECoG) were studied in freely moving and paralyzed rats. In the freely moving rats, 10 mg/kg of baclofen suppressed ECoGs with behavioral sedation, and 20 mg/kg caused whole body twitching accompanied with spi...
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| Veröffentlicht in: | Journal of Neural Transmission 1992-02, Vol.87 (1), p.37-47 |
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| container_title | Journal of Neural Transmission |
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| creator | YOKOI, I AKIYAMA, K KABUTO, H FUKUYAMA, K NISHIJIMA, Y MORI, A |
| description | The effects of intraperitoneally administered baclofen on behavior and electrocorticograms (ECoG) were studied in freely moving and paralyzed rats. In the freely moving rats, 10 mg/kg of baclofen suppressed ECoGs with behavioral sedation, and 20 mg/kg caused whole body twitching accompanied with spike discharges in low voltage slow waves background. In the freely moving rats, baclofen acted as depressant in low dose and convulsant in high dose. In the paralyzed rat, 10 mg/kg of baclofen first suppressed ECoGs. Though fast waves components recovered with slow waves background in the ECoGs of rats paralyzed with gallamine (50 mg/kg) 3 hours after the baclofen injection, fast waves activities were not observed in the ECoG of rats paralyzed with succinylcholine (50 mg/kg), d-tubocurarine (3 mg/kg) or pancuronium (1 mg/kg). Under paralysis with d-tubocurarine, baclofen suppressed ECoG first, and then spike discharges started 90 min after the injection. These results suggest that the effects of baclofen on ECoG were different depending on the muscle relaxant used. |
| doi_str_mv | 10.1007/BF01253109 |
| format | Article |
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In the freely moving rats, 10 mg/kg of baclofen suppressed ECoGs with behavioral sedation, and 20 mg/kg caused whole body twitching accompanied with spike discharges in low voltage slow waves background. In the freely moving rats, baclofen acted as depressant in low dose and convulsant in high dose. In the paralyzed rat, 10 mg/kg of baclofen first suppressed ECoGs. Though fast waves components recovered with slow waves background in the ECoGs of rats paralyzed with gallamine (50 mg/kg) 3 hours after the baclofen injection, fast waves activities were not observed in the ECoG of rats paralyzed with succinylcholine (50 mg/kg), d-tubocurarine (3 mg/kg) or pancuronium (1 mg/kg). Under paralysis with d-tubocurarine, baclofen suppressed ECoG first, and then spike discharges started 90 min after the injection. These results suggest that the effects of baclofen on ECoG were different depending on the muscle relaxant used.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF01253109</identifier><identifier>PMID: 1531592</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Baclofen - antagonists & inhibitors ; Baclofen - pharmacology ; Behavior, Animal - drug effects ; Biological and medical sciences ; Electroencephalography - drug effects ; Electromyography - drug effects ; Gabaergic and benzodiazepinic system ; Gallamine Triethiodide - pharmacology ; Male ; Medical sciences ; Neuromuscular Depolarizing Agents - pharmacology ; Neuromuscular Nondepolarizing Agents - pharmacology ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pancuronium - pharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Stereotaxic Techniques ; Succinylcholine - pharmacology ; Tubocurarine - pharmacology</subject><ispartof>Journal of Neural Transmission, 1992-02, Vol.87 (1), p.37-47</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-1cb5ab610cf54c60d3a46d9321f7fe395d9d1c56b85205c697829d4fbdc553be3</citedby><cites>FETCH-LOGICAL-c280t-1cb5ab610cf54c60d3a46d9321f7fe395d9d1c56b85205c697829d4fbdc553be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4996624$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1531592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOKOI, I</creatorcontrib><creatorcontrib>AKIYAMA, K</creatorcontrib><creatorcontrib>KABUTO, H</creatorcontrib><creatorcontrib>FUKUYAMA, K</creatorcontrib><creatorcontrib>NISHIJIMA, Y</creatorcontrib><creatorcontrib>MORI, A</creatorcontrib><title>Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm Gen Sect</addtitle><description>The effects of intraperitoneally administered baclofen on behavior and electrocorticograms (ECoG) were studied in freely moving and paralyzed rats. In the freely moving rats, 10 mg/kg of baclofen suppressed ECoGs with behavioral sedation, and 20 mg/kg caused whole body twitching accompanied with spike discharges in low voltage slow waves background. In the freely moving rats, baclofen acted as depressant in low dose and convulsant in high dose. In the paralyzed rat, 10 mg/kg of baclofen first suppressed ECoGs. Though fast waves components recovered with slow waves background in the ECoGs of rats paralyzed with gallamine (50 mg/kg) 3 hours after the baclofen injection, fast waves activities were not observed in the ECoG of rats paralyzed with succinylcholine (50 mg/kg), d-tubocurarine (3 mg/kg) or pancuronium (1 mg/kg). Under paralysis with d-tubocurarine, baclofen suppressed ECoG first, and then spike discharges started 90 min after the injection. These results suggest that the effects of baclofen on ECoG were different depending on the muscle relaxant used.</description><subject>Animals</subject><subject>Baclofen - antagonists & inhibitors</subject><subject>Baclofen - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Electroencephalography - drug effects</subject><subject>Electromyography - drug effects</subject><subject>Gabaergic and benzodiazepinic system</subject><subject>Gallamine Triethiodide - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuromuscular Depolarizing Agents - pharmacology</subject><subject>Neuromuscular Nondepolarizing Agents - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pancuronium - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stereotaxic Techniques</subject><subject>Succinylcholine - pharmacology</subject><subject>Tubocurarine - pharmacology</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAUx4Moc04v3oUcPAnVl-ZHm6MOp8JAD3ou6WuyVdJ2JBH0v7fS4U4P3ufD9_Ah5JLBLQMo7h5WwHLJGegjMmeCy4wJxY_JHDhApqUSp-Qsxk8AYKwoZ2TGRlvqfE7cmw3tbmuD8dRgavsN7b4iekuD9ebb9ClS45MNNG0ttc5ZHD-Do7VBPzjb06GfkB9JGHAIqcVhE0wXaTuhYNI5OXHGR3uxvwvysXp8Xz5n69enl-X9OsO8hJQxrKWpFQN0UqCChhuhGs1z5gpnuZaNbhhKVZcyB4lKF2WuG-HqBqXkteULcjPtYhhiDNZVu9B2JvxUDKq_VtWh1ShfTfLuq-5sc1CnOCO_3nMT0XgXTI9t_NeE1krlgv8CqONxnQ</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>YOKOI, I</creator><creator>AKIYAMA, K</creator><creator>KABUTO, H</creator><creator>FUKUYAMA, K</creator><creator>NISHIJIMA, Y</creator><creator>MORI, A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199202</creationdate><title>Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat</title><author>YOKOI, I ; AKIYAMA, K ; KABUTO, H ; FUKUYAMA, K ; NISHIJIMA, Y ; MORI, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-1cb5ab610cf54c60d3a46d9321f7fe395d9d1c56b85205c697829d4fbdc553be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Baclofen - antagonists & inhibitors</topic><topic>Baclofen - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Electroencephalography - drug effects</topic><topic>Electromyography - drug effects</topic><topic>Gabaergic and benzodiazepinic system</topic><topic>Gallamine Triethiodide - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuromuscular Depolarizing Agents - pharmacology</topic><topic>Neuromuscular Nondepolarizing Agents - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pancuronium - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stereotaxic Techniques</topic><topic>Succinylcholine - pharmacology</topic><topic>Tubocurarine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOKOI, I</creatorcontrib><creatorcontrib>AKIYAMA, K</creatorcontrib><creatorcontrib>KABUTO, H</creatorcontrib><creatorcontrib>FUKUYAMA, K</creatorcontrib><creatorcontrib>NISHIJIMA, Y</creatorcontrib><creatorcontrib>MORI, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOKOI, I</au><au>AKIYAMA, K</au><au>KABUTO, H</au><au>FUKUYAMA, K</au><au>NISHIJIMA, Y</au><au>MORI, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm Gen Sect</addtitle><date>1992-02</date><risdate>1992</risdate><volume>87</volume><issue>1</issue><spage>37</spage><epage>47</epage><pages>37-47</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>The effects of intraperitoneally administered baclofen on behavior and electrocorticograms (ECoG) were studied in freely moving and paralyzed rats. In the freely moving rats, 10 mg/kg of baclofen suppressed ECoGs with behavioral sedation, and 20 mg/kg caused whole body twitching accompanied with spike discharges in low voltage slow waves background. In the freely moving rats, baclofen acted as depressant in low dose and convulsant in high dose. In the paralyzed rat, 10 mg/kg of baclofen first suppressed ECoGs. Though fast waves components recovered with slow waves background in the ECoGs of rats paralyzed with gallamine (50 mg/kg) 3 hours after the baclofen injection, fast waves activities were not observed in the ECoG of rats paralyzed with succinylcholine (50 mg/kg), d-tubocurarine (3 mg/kg) or pancuronium (1 mg/kg). Under paralysis with d-tubocurarine, baclofen suppressed ECoG first, and then spike discharges started 90 min after the injection. These results suggest that the effects of baclofen on ECoG were different depending on the muscle relaxant used.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>1531592</pmid><doi>10.1007/BF01253109</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Baclofen - antagonists & inhibitors Baclofen - pharmacology Behavior, Animal - drug effects Biological and medical sciences Electroencephalography - drug effects Electromyography - drug effects Gabaergic and benzodiazepinic system Gallamine Triethiodide - pharmacology Male Medical sciences Neuromuscular Depolarizing Agents - pharmacology Neuromuscular Nondepolarizing Agents - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pancuronium - pharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Stereotaxic Techniques Succinylcholine - pharmacology Tubocurarine - pharmacology |
| title | Peripheral acting muscle relaxants alter the effects of baclofen on the electrocorticograms in the rat |
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