Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia
In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-...
Gespeichert in:
| Veröffentlicht in: | Journal of Neural Transmission 1991-10, Vol.85 (3), p.195-210 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 210 |
|---|---|
| container_issue | 3 |
| container_start_page | 195 |
| container_title | Journal of Neural Transmission |
| container_volume | 85 |
| creator | MAES, M MINNER, B SUY, E VANDERVORST, C RAUS, J |
| description | In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG. |
| doi_str_mv | 10.1007/BF01244945 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF01244945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1930881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c280t-162e65758b3b585d5a9d75c09799a2ab783bdf480c791c70a5f0bf37e375196f3</originalsourceid><addsrcrecordid>eNpFkM1LxDAUxIMo67p68S7k4EmovjRNkxx18QsWvOi5vKbpNtIvmizY_97ILu7pMcyP4c0Qcs3gngHIh6cXYGmW6UyckCXLuEhYlvNTsgQOkGiRZ-fkwvtvAGBMqgVZMM1BKbYkfj3YH-eD67e0mv1kt7sWgxt6T4ealkNoaGgs9XM3YmgGrCbbYxu1D7aj2Fe0mcdIYYudM8nows4FnObkQCYY06nraWdb7E0ztA4vyVmNrbdXh7siXy_Pn-u3ZPPx-r5-3CQmVRASlqc2F1KokpdCiUqgrqQwoKXWmGIpFS-rOlNgpGZGAooayppLy6VgOq_5itztc800-FitLsbJdfG5gkHxN1xxHC7CN3t43JWdrY7ofqno3x589AbbeoptnP_HhNCaKcl_AcLud1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>MAES, M ; MINNER, B ; SUY, E ; VANDERVORST, C ; RAUS, J</creator><creatorcontrib>MAES, M ; MINNER, B ; SUY, E ; VANDERVORST, C ; RAUS, J</creatorcontrib><description>In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF01244945</identifier><identifier>PMID: 1930881</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Adrenal Glands - physiopathology ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Catecholamines - metabolism ; Depressive Disorder - physiopathology ; Dexamethasone - pharmacology ; Dopamine - urine ; Electroencephalography ; Epinephrine - urine ; Female ; Humans ; Hydrocortisone - blood ; Hypothalamo-Hypophyseal System - physiopathology ; Male ; Medical sciences ; Methoxyhydroxyphenylglycol - urine ; Middle Aged ; Mood disorders ; Norepinephrine - urine ; Pituitary-Adrenal System - physiopathology ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sex Factors ; Sympathetic Nervous System - physiopathology</subject><ispartof>Journal of Neural Transmission, 1991-10, Vol.85 (3), p.195-210</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-162e65758b3b585d5a9d75c09799a2ab783bdf480c791c70a5f0bf37e375196f3</citedby><cites>FETCH-LOGICAL-c280t-162e65758b3b585d5a9d75c09799a2ab783bdf480c791c70a5f0bf37e375196f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5599187$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1930881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAES, M</creatorcontrib><creatorcontrib>MINNER, B</creatorcontrib><creatorcontrib>SUY, E</creatorcontrib><creatorcontrib>VANDERVORST, C</creatorcontrib><creatorcontrib>RAUS, J</creatorcontrib><title>Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm Gen Sect</addtitle><description>In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG.</description><subject>Adrenal Glands - physiopathology</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Catecholamines - metabolism</subject><subject>Depressive Disorder - physiopathology</subject><subject>Dexamethasone - pharmacology</subject><subject>Dopamine - urine</subject><subject>Electroencephalography</subject><subject>Epinephrine - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxyhydroxyphenylglycol - urine</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Norepinephrine - urine</subject><subject>Pituitary-Adrenal System - physiopathology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sex Factors</subject><subject>Sympathetic Nervous System - physiopathology</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAUxIMo67p68S7k4EmovjRNkxx18QsWvOi5vKbpNtIvmizY_97ILu7pMcyP4c0Qcs3gngHIh6cXYGmW6UyckCXLuEhYlvNTsgQOkGiRZ-fkwvtvAGBMqgVZMM1BKbYkfj3YH-eD67e0mv1kt7sWgxt6T4ealkNoaGgs9XM3YmgGrCbbYxu1D7aj2Fe0mcdIYYudM8nows4FnObkQCYY06nraWdb7E0ztA4vyVmNrbdXh7siXy_Pn-u3ZPPx-r5-3CQmVRASlqc2F1KokpdCiUqgrqQwoKXWmGIpFS-rOlNgpGZGAooayppLy6VgOq_5itztc800-FitLsbJdfG5gkHxN1xxHC7CN3t43JWdrY7ofqno3x589AbbeoptnP_HhNCaKcl_AcLud1g</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>MAES, M</creator><creator>MINNER, B</creator><creator>SUY, E</creator><creator>VANDERVORST, C</creator><creator>RAUS, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199110</creationdate><title>Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia</title><author>MAES, M ; MINNER, B ; SUY, E ; VANDERVORST, C ; RAUS, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-162e65758b3b585d5a9d75c09799a2ab783bdf480c791c70a5f0bf37e375196f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenal Glands - physiopathology</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Catecholamines - metabolism</topic><topic>Depressive Disorder - physiopathology</topic><topic>Dexamethasone - pharmacology</topic><topic>Dopamine - urine</topic><topic>Electroencephalography</topic><topic>Epinephrine - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxyhydroxyphenylglycol - urine</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Norepinephrine - urine</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sex Factors</topic><topic>Sympathetic Nervous System - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAES, M</creatorcontrib><creatorcontrib>MINNER, B</creatorcontrib><creatorcontrib>SUY, E</creatorcontrib><creatorcontrib>VANDERVORST, C</creatorcontrib><creatorcontrib>RAUS, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAES, M</au><au>MINNER, B</au><au>SUY, E</au><au>VANDERVORST, C</au><au>RAUS, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm Gen Sect</addtitle><date>1991-10</date><risdate>1991</risdate><volume>85</volume><issue>3</issue><spage>195</spage><epage>210</epage><pages>195-210</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>1930881</pmid><doi>10.1007/BF01244945</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9564 |
| ispartof | Journal of Neural Transmission, 1991-10, Vol.85 (3), p.195-210 |
| issn | 0300-9564 1435-1463 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01244945 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adrenal Glands - physiopathology Adult Adult and adolescent clinical studies Biological and medical sciences Catecholamines - metabolism Depressive Disorder - physiopathology Dexamethasone - pharmacology Dopamine - urine Electroencephalography Epinephrine - urine Female Humans Hydrocortisone - blood Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Methoxyhydroxyphenylglycol - urine Middle Aged Mood disorders Norepinephrine - urine Pituitary-Adrenal System - physiopathology Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sex Factors Sympathetic Nervous System - physiopathology |
| title | Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T17%3A36%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coexisting%20dysregulations%20of%20both%20the%20sympathoadrenal%20system%20and%20hypothalamic-pituitary-adrenal-axis%20in%20melancholia&rft.jtitle=Journal%20of%20Neural%20Transmission&rft.au=MAES,%20M&rft.date=1991-10&rft.volume=85&rft.issue=3&rft.spage=195&rft.epage=210&rft.pages=195-210&rft.issn=0300-9564&rft.eissn=1435-1463&rft.coden=JNTMAH&rft_id=info:doi/10.1007/BF01244945&rft_dat=%3Cpubmed_cross%3E1930881%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/1930881&rfr_iscdi=true |