Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro

It was shown that cyclopeptolide SDZ 214-103 (10 microM) is more active in rhodamine-123 accumulation in actinomycin-D-resistant human lymphoma cells CCRF/ACTD400 than cyclosporin A (10 microM), but equipotent in the doxorubicin-resistant Friend erythroleukemia cell line F4-6/ADR. In F4-6/ADR cells,...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 1995-07, Vol.121 (7), p.407-412
Hauptverfasser:	SCHWABE, K, STEINHEIDER, G, LAWEN, A, TRABER, R, HILDEBRANDT, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cyclosporins - biosynthesis Cyclosporins - pharmacology Dactinomycin - pharmacology Doxorubicin - pharmacology Drug Interactions Drug Resistance, Microbial - physiology Drug Resistance, Multiple Drug Screening Assays, Antitumor Friend murine leukemia virus General aspects Humans Immunosuppressive Agents - pharmacology Leukemia, Erythroblastic, Acute - drug therapy Leukemia, Erythroblastic, Acute - metabolism Leukemia, Erythroblastic, Acute - virology Lymphoma - drug therapy Lymphoma - metabolism Medical sciences Pharmacology. Drug treatments Rhodamine 123 Rhodamines - pharmacokinetics Tetrazolium Salts Thiazoles Tumor Cells, Cultured - drug effects
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