Antitumour effect of a gonadotropin-releasing-hormone antagonist (MI-1544) and its conjugate on human breast cancer cells and their xenografts

Our gonadotropin-releasing hormone (GnRH) antagonist analogue MI-1544 ([Ac-D-Trp1,3,D-Cpa2,D-Lys6,D-Ala10]GnRH) was developed as a potential contraceptive material, because it decreased the luteinizing hormone level without unfavourable side-effects. The antagonist was covalently bound to poly[Lys-(...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 1994-10, Vol.120 (10), p.578-584
Hauptverfasser:	VINCZE, B, PALYI, I, DAUBNER, D, KALNAY, A, MEZÖ, G, HUDECZ, F, SZEKERKE, M, TEPLAN, I, MEZÖ, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Division - drug effects Cell Line Cell Survival - drug effects Chemotherapy Female Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - metabolism Gonadotropin-Releasing Hormone - therapeutic use Gonadotropin-Releasing Hormone - toxicity Humans Immunosuppression Medical sciences Mice Mice, Inbred CBA Molecular Sequence Data Pharmacology. Drug treatments Thymectomy Transplantation, Heterologous Tumor Cells, Cultured
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