Progression of amiodarone induced cataracts
Amiodarone hydrochloride is a potent antiarrhythmic agent recently approved for use by the Food and Drug Administration. Anterior subcapsular lens opacities were observed in seven of fourteen patients treated with moderate to high doses of amiodarone at the Veterans Administration Medical Center in...
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| Veröffentlicht in: | Documenta ophthalmologica 1993-01, Vol.83 (4), p.323-329 |
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| container_title | Documenta ophthalmologica |
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| creator | FLACH, A. J DOLAN, B. J |
| description | Amiodarone hydrochloride is a potent antiarrhythmic agent recently approved for use by the Food and Drug Administration. Anterior subcapsular lens opacities were observed in seven of fourteen patients treated with moderate to high doses of amiodarone at the Veterans Administration Medical Center in San Francisco in 1982. The present report summarizes the present status of these same fourteen patients ten years later. Anterior subcapsular lens opacities developed or progressed in all patients continuing treatment with this antiarrhythmic agent during the following ten year interval. Although Snellen visual acuities are not decreased, subtle visual impairment is present as measured by contrast sensitivity measurements with and without glare. This decrease in visual acuity is not a contraindication for therapy with this potentially life saving drug. |
| doi_str_mv | 10.1007/BF01204334 |
| format | Article |
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This decrease in visual acuity is not a contraindication for therapy with this potentially life saving drug.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/BF01204334</identifier><identifier>PMID: 8223102</identifier><identifier>CODEN: DOOPAA</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Aged ; Amiodarone - adverse effects ; Arrhythmias, Cardiac - drug therapy ; Biological and medical sciences ; Cataract - chemically induced ; Cataract - pathology ; Contrast Sensitivity ; Drug toxicity and drugs side effects treatment ; Follow-Up Studies ; Humans ; Lens, Crystalline - drug effects ; Lens, Crystalline - pathology ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Toxicity: osteoarticular system ; Vision Disorders - diagnosis ; Visual Acuity</subject><ispartof>Documenta ophthalmologica, 1993-01, Vol.83 (4), p.323-329</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-3b87b6b77221567c6ea4392e727d23e0f016b45e181f1b8a030cc114197427e03</citedby><cites>FETCH-LOGICAL-c311t-3b87b6b77221567c6ea4392e727d23e0f016b45e181f1b8a030cc114197427e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3745365$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8223102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FLACH, A. J</creatorcontrib><creatorcontrib>DOLAN, B. J</creatorcontrib><title>Progression of amiodarone induced cataracts</title><title>Documenta ophthalmologica</title><addtitle>Doc Ophthalmol</addtitle><description>Amiodarone hydrochloride is a potent antiarrhythmic agent recently approved for use by the Food and Drug Administration. Anterior subcapsular lens opacities were observed in seven of fourteen patients treated with moderate to high doses of amiodarone at the Veterans Administration Medical Center in San Francisco in 1982. The present report summarizes the present status of these same fourteen patients ten years later. Anterior subcapsular lens opacities developed or progressed in all patients continuing treatment with this antiarrhythmic agent during the following ten year interval. Although Snellen visual acuities are not decreased, subtle visual impairment is present as measured by contrast sensitivity measurements with and without glare. This decrease in visual acuity is not a contraindication for therapy with this potentially life saving drug.</description><subject>Aged</subject><subject>Amiodarone - adverse effects</subject><subject>Arrhythmias, Cardiac - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Cataract - chemically induced</subject><subject>Cataract - pathology</subject><subject>Contrast Sensitivity</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lens, Crystalline - drug effects</subject><subject>Lens, Crystalline - pathology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: osteoarticular system</subject><subject>Vision Disorders - diagnosis</subject><subject>Visual Acuity</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj89LwzAcxYMos04v3oUePCnV7480SY86nAoDPei5pGkqla0dSXfwv7eyMk8P3vvw4CPEJcIdAuj7xyUggWSWRyLBXHNGiuhYJDD2mZRGnYqzGL8BoNBoZmJmiBiBEnH7Hvqv4GNs-y7tm9Ru2r62oe982nb1zvk6dXawwbohnouTxq6jv5hyLj6XTx-Ll2z19vy6eFhljhGHjCujK1VpTYS50k55K7kgr0nXxB4aQFXJ3KPBBitjgcE5RImFlqQ98Fzc7H9d6GMMvim3od3Y8FMilH_C5b_wCF_t4e2u2vj6gE6G43497TY6u26C7VwbDxhrmbPK-RfOA1og</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>FLACH, A. J</creator><creator>DOLAN, B. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-3b87b6b77221567c6ea4392e727d23e0f016b45e181f1b8a030cc114197427e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aged</topic><topic>Amiodarone - adverse effects</topic><topic>Arrhythmias, Cardiac - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Cataract - chemically induced</topic><topic>Cataract - pathology</topic><topic>Contrast Sensitivity</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lens, Crystalline - drug effects</topic><topic>Lens, Crystalline - pathology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: osteoarticular system</topic><topic>Vision Disorders - diagnosis</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FLACH, A. J</creatorcontrib><creatorcontrib>DOLAN, B. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FLACH, A. J</au><au>DOLAN, B. 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Anterior subcapsular lens opacities developed or progressed in all patients continuing treatment with this antiarrhythmic agent during the following ten year interval. Although Snellen visual acuities are not decreased, subtle visual impairment is present as measured by contrast sensitivity measurements with and without glare. This decrease in visual acuity is not a contraindication for therapy with this potentially life saving drug.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>8223102</pmid><doi>10.1007/BF01204334</doi><tpages>7</tpages></addata></record> |
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| ispartof | Documenta ophthalmologica, 1993-01, Vol.83 (4), p.323-329 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Amiodarone - adverse effects Arrhythmias, Cardiac - drug therapy Biological and medical sciences Cataract - chemically induced Cataract - pathology Contrast Sensitivity Drug toxicity and drugs side effects treatment Follow-Up Studies Humans Lens, Crystalline - drug effects Lens, Crystalline - pathology Longitudinal Studies Male Medical sciences Middle Aged Pharmacology. Drug treatments Toxicity: osteoarticular system Vision Disorders - diagnosis Visual Acuity |
| title | Progression of amiodarone induced cataracts |
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