The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program
The avidin-biotin immunoperoxidase method and antisera against highly purified porcine relaxin were utilized to localize relaxin-like immunoreactivity in biopsied specimens from six preovulatory follicles from four women undergoing laparoscopy for oocyte retrieval in an in vitro fertilization progra...
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| Veröffentlicht in: | Journal of In Vitro Fertilization and Embryo Transfer 1984-09, Vol.1 (3), p.180-182 |
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| container_end_page | 182 |
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| container_issue | 3 |
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| container_title | Journal of In Vitro Fertilization and Embryo Transfer |
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| creator | Yki-Järvinen, H Wahlström, T Tenhunen, A Koskimies, A I Seppälä, M |
| description | The avidin-biotin immunoperoxidase method and antisera against highly purified porcine relaxin were utilized to localize relaxin-like immunoreactivity in biopsied specimens from six preovulatory follicles from four women undergoing laparoscopy for oocyte retrieval in an in vitro fertilization program. By histological criteria, three of the follicles were luteinized and three were not. Relaxin was found in the granulosa cells of those cells which showed histological luteinization, whereas no relaxin was found in the nonluteinized preovulatory follicles. Our results show, for the first time, the occurrence of relaxin in the human ovary before ovulation and they suggest that the appearance of relaxin is related to the luteinization process. |
| doi_str_mv | 10.1007/BF01139211 |
| format | Article |
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By histological criteria, three of the follicles were luteinized and three were not. Relaxin was found in the granulosa cells of those cells which showed histological luteinization, whereas no relaxin was found in the nonluteinized preovulatory follicles. 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Our results show, for the first time, the occurrence of relaxin in the human ovary before ovulation and they suggest that the appearance of relaxin is related to the luteinization process.</description><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Clomiphene - pharmacology</subject><subject>Corpus Luteum - drug effects</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Humans</subject><subject>Menotropins - pharmacology</subject><subject>Ovarian Follicle - analysis</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovulation</subject><subject>Relaxin - analysis</subject><subject>Time Factors</subject><issn>0740-7769</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc8xdvAs9eRCqSdPmNUcVp8LAyzyXNH11kXSZSTs2_3ozNzQ8yMd7v-89-Ai5ZPSWUQp3DzPKGJcZYydkzArgKXBOT8mYQk5TACHPyTSETxofl5yxbERGIs-jKsdku1hi4rQevMeVjrJNPFq1Nask1nK3Rh960w1W9dgky6FTq2Tt0W32Hed3SeusNdpiSHRUqPdYdKpf_8b03iUt-t5Y86164_Zu9-FVd0HOWmUDTo__hLzPnhaPL-n87fn18X6eaiahT4UQNefY5FCrEgGbqFReFCB5HNEyy9oW60w0JUDDZM6pBKCqqVEIgLzkE3J92Bvvfg0Y-qozQaO1aoVuCBUUUsicFRG8OYDauxA8ttXam075XcVotU-6-k86wlfHrUPdYfOHHnPlP00neho</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Yki-Järvinen, H</creator><creator>Wahlström, T</creator><creator>Tenhunen, A</creator><creator>Koskimies, A I</creator><creator>Seppälä, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198409</creationdate><title>The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program</title><author>Yki-Järvinen, H ; Wahlström, T ; Tenhunen, A ; Koskimies, A I ; Seppälä, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c197t-666b33ed47ba8e7edd47a4557936660822ffeb26d877d194309770adbe6677483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Clomiphene - pharmacology</topic><topic>Corpus Luteum - drug effects</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Humans</topic><topic>Menotropins - pharmacology</topic><topic>Ovarian Follicle - analysis</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovulation</topic><topic>Relaxin - analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yki-Järvinen, H</creatorcontrib><creatorcontrib>Wahlström, T</creatorcontrib><creatorcontrib>Tenhunen, A</creatorcontrib><creatorcontrib>Koskimies, A I</creatorcontrib><creatorcontrib>Seppälä, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of In Vitro Fertilization and Embryo Transfer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yki-Järvinen, H</au><au>Wahlström, T</au><au>Tenhunen, A</au><au>Koskimies, A I</au><au>Seppälä, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program</atitle><jtitle>Journal of In Vitro Fertilization and Embryo Transfer</jtitle><addtitle>J In Vitro Fert Embryo Transf</addtitle><date>1984-09</date><risdate>1984</risdate><volume>1</volume><issue>3</issue><spage>180</spage><epage>182</epage><pages>180-182</pages><issn>0740-7769</issn><eissn>1573-7330</eissn><abstract>The avidin-biotin immunoperoxidase method and antisera against highly purified porcine relaxin were utilized to localize relaxin-like immunoreactivity in biopsied specimens from six preovulatory follicles from four women undergoing laparoscopy for oocyte retrieval in an in vitro fertilization program. 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| fulltext | fulltext |
| identifier | ISSN: 0740-7769 |
| ispartof | Journal of In Vitro Fertilization and Embryo Transfer, 1984-09, Vol.1 (3), p.180-182 |
| issn | 0740-7769 1573-7330 |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Chorionic Gonadotropin - pharmacology Clomiphene - pharmacology Corpus Luteum - drug effects Female Fertilization in Vitro Humans Menotropins - pharmacology Ovarian Follicle - analysis Ovarian Follicle - drug effects Ovulation Relaxin - analysis Time Factors |
| title | The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program |
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