Immunological responses of breast cancer patients to behavioral interventions
This article reports the results of an 18-month study of immune system and psychological changes in stage 1 breast cancer patients provided with relaxation, guided imagery, and biofeedback training. Thirteen lymph node negative patients who had recovered from a modified radical mastectomy were rando...
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| Veröffentlicht in: | Biofeedback and Self-Regulation 1993-03, Vol.18 (1), p.1-22 |
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| container_title | Biofeedback and Self-Regulation |
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| creator | GRUBER, B. L HERSH, S. P HALL, N. R. S WALETZKY, L. R KUNZ, J. F CARPENTER, J. K KVERNO, K. S WEISS, S. M |
| description | This article reports the results of an 18-month study of immune system and psychological changes in stage 1 breast cancer patients provided with relaxation, guided imagery, and biofeedback training. Thirteen lymph node negative patients who had recovered from a modified radical mastectomy were randomly assigned to either an immediate treatment or a delayed treatment control group. Multiple pre-post psychological measures were performed. Significant effects were found in natural killer cell (NK) activity (p < .017), mixed lymphocyte responsiveness (MLR) (p < .001), concanavalin A (Con-A) responsiveness (p < .001), and the number of peripheral blood lymphocytes (PBL) (p < .01). No significant psychological changes were detected; however, reductions were seen in psychological inventory scales measuring anxiety. The results show that behavioral interventions can be correlated with immune system measures, thereby replicating the results of an earlier pilot study from our Center. Discussion is provided on differential T-cell and B-cell responsiveness to behavioral interventions. |
| doi_str_mv | 10.1007/BF00999510 |
| format | Article |
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L ; HERSH, S. P ; HALL, N. R. S ; WALETZKY, L. R ; KUNZ, J. F ; CARPENTER, J. K ; KVERNO, K. S ; WEISS, S. M</creator><creatorcontrib>GRUBER, B. L ; HERSH, S. P ; HALL, N. R. S ; WALETZKY, L. R ; KUNZ, J. F ; CARPENTER, J. K ; KVERNO, K. S ; WEISS, S. M</creatorcontrib><description>This article reports the results of an 18-month study of immune system and psychological changes in stage 1 breast cancer patients provided with relaxation, guided imagery, and biofeedback training. Thirteen lymph node negative patients who had recovered from a modified radical mastectomy were randomly assigned to either an immediate treatment or a delayed treatment control group. Multiple pre-post psychological measures were performed. Significant effects were found in natural killer cell (NK) activity (p < .017), mixed lymphocyte responsiveness (MLR) (p < .001), concanavalin A (Con-A) responsiveness (p < .001), and the number of peripheral blood lymphocytes (PBL) (p < .01). No significant psychological changes were detected; however, reductions were seen in psychological inventory scales measuring anxiety. The results show that behavioral interventions can be correlated with immune system measures, thereby replicating the results of an earlier pilot study from our Center. Discussion is provided on differential T-cell and B-cell responsiveness to behavioral interventions.</description><identifier>ISSN: 0363-3586</identifier><identifier>EISSN: 1573-3270</identifier><identifier>DOI: 10.1007/BF00999510</identifier><identifier>PMID: 8448236</identifier><identifier>CODEN: BSELDP</identifier><language>eng</language><publisher>New York, NY: Plenum</publisher><subject>Adult ; Analysis of Variance ; Behavior Therapy ; Biofeedback, Psychology ; Biological and medical sciences ; Breast Neoplasms - immunology ; Breast Neoplasms - psychology ; Concanavalin A - pharmacology ; Female ; Humans ; Immune System - immunology ; Immune System - physiopathology ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Medical sciences ; Middle Aged ; Personality Inventory ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Relaxation. Biofeedback. Hypnosis. Selfregulation. 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L</creatorcontrib><creatorcontrib>HERSH, S. P</creatorcontrib><creatorcontrib>HALL, N. R. S</creatorcontrib><creatorcontrib>WALETZKY, L. R</creatorcontrib><creatorcontrib>KUNZ, J. F</creatorcontrib><creatorcontrib>CARPENTER, J. K</creatorcontrib><creatorcontrib>KVERNO, K. S</creatorcontrib><creatorcontrib>WEISS, S. M</creatorcontrib><title>Immunological responses of breast cancer patients to behavioral interventions</title><title>Biofeedback and Self-Regulation</title><addtitle>Biofeedback Self Regul</addtitle><description>This article reports the results of an 18-month study of immune system and psychological changes in stage 1 breast cancer patients provided with relaxation, guided imagery, and biofeedback training. Thirteen lymph node negative patients who had recovered from a modified radical mastectomy were randomly assigned to either an immediate treatment or a delayed treatment control group. Multiple pre-post psychological measures were performed. Significant effects were found in natural killer cell (NK) activity (p < .017), mixed lymphocyte responsiveness (MLR) (p < .001), concanavalin A (Con-A) responsiveness (p < .001), and the number of peripheral blood lymphocytes (PBL) (p < .01). No significant psychological changes were detected; however, reductions were seen in psychological inventory scales measuring anxiety. The results show that behavioral interventions can be correlated with immune system measures, thereby replicating the results of an earlier pilot study from our Center. Discussion is provided on differential T-cell and B-cell responsiveness to behavioral interventions.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Behavior Therapy</subject><subject>Biofeedback, Psychology</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - psychology</subject><subject>Concanavalin A - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Immune System - immunology</subject><subject>Immune System - physiopathology</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Personality Inventory</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Relaxation. Biofeedback. Hypnosis. Selfregulation. Meditation</subject><subject>Treatments</subject><issn>0363-3586</issn><issn>1573-3270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5iAchut_JHrVYLVS86DlsNhNdSbJxNyn4793SUE8z8D7vMDwIXRJ8RzDO7h9XGCulBMFHaE5ExlJGM3yM5pjJuItcnqKzEL4xZlRJOkOznPOcMjlHr-u2HTvXuE9rdJN4CL3rAoTE1UnpQYchMboz4JNeDxa6ISSDS0r40lvrfGzYbgC_jYGNvXN0UusmwMU0F-hj9fS-fEk3b8_r5cMmNUzQIaUSKsKB1KQ0FRcyy1XFssoIwkguhZFUCagragw2ueAqg1oqDpEsQTEm2ALd7O_23v2MEIaitcFA0-gO3BiKTEhCRb4Db_eg8S4ED3XRe9tq_1sQXOzcFf_uInw1XR3LFqoDOsmK-fWU6xBl1T6KseGA8fi2wpz9ASJ1di4</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>GRUBER, B. L</creator><creator>HERSH, S. P</creator><creator>HALL, N. R. S</creator><creator>WALETZKY, L. R</creator><creator>KUNZ, J. F</creator><creator>CARPENTER, J. K</creator><creator>KVERNO, K. S</creator><creator>WEISS, S. M</creator><general>Plenum</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Immunological responses of breast cancer patients to behavioral interventions</title><author>GRUBER, B. L ; HERSH, S. P ; HALL, N. R. S ; WALETZKY, L. R ; KUNZ, J. F ; CARPENTER, J. K ; KVERNO, K. S ; WEISS, S. 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Significant effects were found in natural killer cell (NK) activity (p < .017), mixed lymphocyte responsiveness (MLR) (p < .001), concanavalin A (Con-A) responsiveness (p < .001), and the number of peripheral blood lymphocytes (PBL) (p < .01). No significant psychological changes were detected; however, reductions were seen in psychological inventory scales measuring anxiety. The results show that behavioral interventions can be correlated with immune system measures, thereby replicating the results of an earlier pilot study from our Center. Discussion is provided on differential T-cell and B-cell responsiveness to behavioral interventions.</abstract><cop>New York, NY</cop><pub>Plenum</pub><pmid>8448236</pmid><doi>10.1007/BF00999510</doi><tpages>22</tpages></addata></record> |
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| subjects | Adult Analysis of Variance Behavior Therapy Biofeedback, Psychology Biological and medical sciences Breast Neoplasms - immunology Breast Neoplasms - psychology Concanavalin A - pharmacology Female Humans Immune System - immunology Immune System - physiopathology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lymphocytes - drug effects Lymphocytes - immunology Medical sciences Middle Aged Personality Inventory Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Relaxation. Biofeedback. Hypnosis. Selfregulation. Meditation Treatments |
| title | Immunological responses of breast cancer patients to behavioral interventions |
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