Large increase in disulphide bonds containing cytosol proteins after chronic cadmium administration, estimated in isolated rat liver cells
Using histochemical staining, followed by cytophotometric quantitation of disulphide bonds and total protein in isolated liver cells of rats treated for a long time with low doses of CdCl2, a large increase in disulphide bonds containing proteins could be demonstrated in cells of one ploidy class. T...
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| Veröffentlicht in: | Histochemistry 1985, Vol.83 (3), p.227-229 |
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| container_title | Histochemistry |
| container_volume | 83 |
| creator | MORSELT, A. F. W VAN DE HAMER, C. J. A PRINSEN, L JONGSTRA-SPAAPEN, E. J COPIUS PEEREBOOM-STEGEMAN, J. H. J BOSCH, K. S |
| description | Using histochemical staining, followed by cytophotometric quantitation of disulphide bonds and total protein in isolated liver cells of rats treated for a long time with low doses of CdCl2, a large increase in disulphide bonds containing proteins could be demonstrated in cells of one ploidy class. This increase seems to be due to an increase in high molecular weight (HMW) cytosol proteins as estimated biochemically. They probably represent polymers of metallothionein. |
| doi_str_mv | 10.1007/BF00953988 |
| format | Article |
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They probably represent polymers of metallothionein.</description><identifier>ISSN: 0301-5564</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/BF00953988</identifier><identifier>PMID: 4044307</identifier><identifier>CODEN: HCMYAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cadmium - pharmacology ; Cytosol - metabolism ; Disulfides - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Kinetics ; Liver - cytology ; Liver - drug effects ; Liver - metabolism ; Liver. Bile. 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They probably represent polymers of metallothionein.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cadmium - pharmacology</subject><subject>Cytosol - metabolism</subject><subject>Disulfides - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Liver - cytology</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver. Bile. 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W</creatorcontrib><creatorcontrib>VAN DE HAMER, C. J. A</creatorcontrib><creatorcontrib>PRINSEN, L</creatorcontrib><creatorcontrib>JONGSTRA-SPAAPEN, E. J</creatorcontrib><creatorcontrib>COPIUS PEEREBOOM-STEGEMAN, J. H. J</creatorcontrib><creatorcontrib>BOSCH, K. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORSELT, A. F. W</au><au>VAN DE HAMER, C. J. A</au><au>PRINSEN, L</au><au>JONGSTRA-SPAAPEN, E. J</au><au>COPIUS PEEREBOOM-STEGEMAN, J. H. J</au><au>BOSCH, K. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large increase in disulphide bonds containing cytosol proteins after chronic cadmium administration, estimated in isolated rat liver cells</atitle><jtitle>Histochemistry</jtitle><addtitle>Histochemistry</addtitle><date>1985</date><risdate>1985</risdate><volume>83</volume><issue>3</issue><spage>227</spage><epage>229</epage><pages>227-229</pages><issn>0301-5564</issn><eissn>1432-119X</eissn><coden>HCMYAL</coden><abstract>Using histochemical staining, followed by cytophotometric quantitation of disulphide bonds and total protein in isolated liver cells of rats treated for a long time with low doses of CdCl2, a large increase in disulphide bonds containing proteins could be demonstrated in cells of one ploidy class. This increase seems to be due to an increase in high molecular weight (HMW) cytosol proteins as estimated biochemically. They probably represent polymers of metallothionein.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>4044307</pmid><doi>10.1007/BF00953988</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0301-5564 |
| ispartof | Histochemistry, 1985, Vol.83 (3), p.227-229 |
| issn | 0301-5564 1432-119X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00953988 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Cadmium - pharmacology Cytosol - metabolism Disulfides - metabolism Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Kinetics Liver - cytology Liver - drug effects Liver - metabolism Liver. Bile. Biliary tracts Proteins - metabolism Rats Rats, Inbred Strains Vertebrates: digestive system |
| title | Large increase in disulphide bonds containing cytosol proteins after chronic cadmium administration, estimated in isolated rat liver cells |
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