Irradiation cataract in children after bone marrow transplantation
Chemotherapy and radiation produce a dose-dependent anti-leukemic effect. Combined chemoradiotherapy and bone marrow transplantation (BMT) were given in our clinic to treat children with acute leukemias. Total body irradiation of 10 Gy in a single dose was used. One long-term side effect of this tre...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1990-01, Vol.228 (3), p.218-221 |
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| creator | LAPPI, M RAJANTIE, J UUSITALO, R. J |
| description | Chemotherapy and radiation produce a dose-dependent anti-leukemic effect. Combined chemoradiotherapy and bone marrow transplantation (BMT) were given in our clinic to treat children with acute leukemias. Total body irradiation of 10 Gy in a single dose was used. One long-term side effect of this treatment was the development of subcapsular cataract; this was seen in all nine long-term survivors of the 17 children with acute lymphoblastic (ALL) or acute myelogenous (AML) leukemia who were treated as described above. One year after marrow transplantation, all the eyes studied had visual acuity of 20/20 and an optically clear lens. Three years later, 60% of the eyes had visual acuity of less than 20/40 and all had posterior, subcapsular cataracts. The cataract in all cases was quite uniform, consisting of opacities in the posterior subcapsular region. Cataract formation was treatment-related and seemed to correlate only to the type of total body irradiation. We concluded that the cataracts seen in the present study were a late complication of allogeneic BMT and were specifically due to the single-dose total body irradiation. |
| doi_str_mv | 10.1007/BF00920023 |
| format | Article |
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Graft versus host reaction ; Cataract - diagnosis ; Cataract - etiology ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Graft vs Host Reaction ; Humans ; Leukemia - surgery ; Male ; Medical sciences ; Radiotherapy - adverse effects ; Transfusions. Complications. Transfusion reactions. 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J</creatorcontrib><title>Irradiation cataract in children after bone marrow transplantation</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Chemotherapy and radiation produce a dose-dependent anti-leukemic effect. Combined chemoradiotherapy and bone marrow transplantation (BMT) were given in our clinic to treat children with acute leukemias. Total body irradiation of 10 Gy in a single dose was used. One long-term side effect of this treatment was the development of subcapsular cataract; this was seen in all nine long-term survivors of the 17 children with acute lymphoblastic (ALL) or acute myelogenous (AML) leukemia who were treated as described above. One year after marrow transplantation, all the eyes studied had visual acuity of 20/20 and an optically clear lens. Three years later, 60% of the eyes had visual acuity of less than 20/40 and all had posterior, subcapsular cataracts. The cataract in all cases was quite uniform, consisting of opacities in the posterior subcapsular region. Cataract formation was treatment-related and seemed to correlate only to the type of total body irradiation. We concluded that the cataracts seen in the present study were a late complication of allogeneic BMT and were specifically due to the single-dose total body irradiation.</description><subject>Adolescent</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cataract - diagnosis</subject><subject>Cataract - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft vs Host Reaction</subject><subject>Humans</subject><subject>Leukemia - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radiotherapy - adverse effects</subject><subject>Transfusions. Complications. Transfusion reactions. 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Graft versus host reaction</topic><topic>Cataract - diagnosis</topic><topic>Cataract - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft vs Host Reaction</topic><topic>Humans</topic><topic>Leukemia - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radiotherapy - adverse effects</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Ultrasonography</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAPPI, M</creatorcontrib><creatorcontrib>RAJANTIE, J</creatorcontrib><creatorcontrib>UUSITALO, R. 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One long-term side effect of this treatment was the development of subcapsular cataract; this was seen in all nine long-term survivors of the 17 children with acute lymphoblastic (ALL) or acute myelogenous (AML) leukemia who were treated as described above. One year after marrow transplantation, all the eyes studied had visual acuity of 20/20 and an optically clear lens. Three years later, 60% of the eyes had visual acuity of less than 20/40 and all had posterior, subcapsular cataracts. The cataract in all cases was quite uniform, consisting of opacities in the posterior subcapsular region. Cataract formation was treatment-related and seemed to correlate only to the type of total body irradiation. We concluded that the cataracts seen in the present study were a late complication of allogeneic BMT and were specifically due to the single-dose total body irradiation.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2193848</pmid><doi>10.1007/BF00920023</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 1990-01, Vol.228 (3), p.218-221 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation - adverse effects Bone marrow, stem cells transplantation. Graft versus host reaction Cataract - diagnosis Cataract - etiology Child Child, Preschool Female Follow-Up Studies Graft vs Host Reaction Humans Leukemia - surgery Male Medical sciences Radiotherapy - adverse effects Transfusions. Complications. Transfusion reactions. Cell and gene therapy Ultrasonography Visual Acuity |
| title | Irradiation cataract in children after bone marrow transplantation |
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