Retinal detachment and degeneration in response to subretinal perfluorodecalin in rabbit eyes
Perfluorocarbon liquids, including perfluorodecalin (PFD), are useful intraoperative tools in complicated vitreoretinal surgery, such as for giant retinal tears, PVR and intraocular foreign bodies. Due to its high specific gravity (1.91 g/cm3) subretinal complications of PFD may occur. The consequen...
Gespeichert in:
| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1993-04, Vol.231 (4), p.233-237 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 237 |
|---|---|
| container_issue | 4 |
| container_start_page | 233 |
| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 231 |
| creator | BERGLIN, L REN, J ALGVERE, P. V |
| description | Perfluorocarbon liquids, including perfluorodecalin (PFD), are useful intraoperative tools in complicated vitreoretinal surgery, such as for giant retinal tears, PVR and intraocular foreign bodies. Due to its high specific gravity (1.91 g/cm3) subretinal complications of PFD may occur. The consequences of subretinal PFD were studied in 23 albino rabbits (28 eyes). Using glass micropipettes (outer diameter of tip 100-120 microns), we injected 50-100 microliters PFD subretinally via the vitreous space. The same volume of BSS was injected into 18 control eyes. Eyes were monitored by indirect ophthalmoscopy and examined by light and electron microscopy at 1, 2 and 3 days, and 1, 2, 4 and 12 weeks. Progressive retinal detachments with newly formed retinal breaks in the inferior quadrants developed in 26 of 28 eyes. As early as 1 day postoperatively, subretinal PFD induced loss of outer and inner segments. Local retinal necrosis occurred in 4 eyes 5-7 days after surgery. A marked vacuole formation in retinal layers and PFD emulsification were regularly seen. The control eyes healed spontaneously. Toxic, mechanical and barrier effects may have caused the retinal damage. We advocate that all PFD be removed from the eye at surgery. |
| doi_str_mv | 10.1007/BF00918847 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00918847</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8486306</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-3c93cdf5ae7bf01e3e29370d48eabbb9e716866edb5044b76c44c6644e78dc83</originalsourceid><addsrcrecordid>eNpFkE1Lw0AQhhdRaq1evAs5eBKis9nN7uaoxapQEKSHXiTsx0Qj6Sbspof-eyMJ9TQM7zMvzEPINYV7CiAfnlYABVWKyxMyp5zlqYRse0rmIDOaKpZtz8lFjD8AMIR0RmaKK8FAzMnnB_a1103isNf2e4e-T7R3w_qFHoPu69YntU8Cxq71EZO-TeLehOmqw1A1-za0Dq1u6hHVxtR9ggeMl-Ss0k3Eq2kuyGb1vFm-puv3l7fl4zq1jNI-ZbZg1lW5RmkqoMgwK5gExxUOXaZASYUSAp3JgXMjheXcCsE5SuWsYgtyN9ba0MYYsCq7UO90OJQUyj9D5b-hAb4Z4W5vduiO6KRkyG-nXMfhpypob-t4xLjMRF4A-wXR0W8t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Retinal detachment and degeneration in response to subretinal perfluorodecalin in rabbit eyes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>BERGLIN, L ; REN, J ; ALGVERE, P. V</creator><creatorcontrib>BERGLIN, L ; REN, J ; ALGVERE, P. V</creatorcontrib><description>Perfluorocarbon liquids, including perfluorodecalin (PFD), are useful intraoperative tools in complicated vitreoretinal surgery, such as for giant retinal tears, PVR and intraocular foreign bodies. Due to its high specific gravity (1.91 g/cm3) subretinal complications of PFD may occur. The consequences of subretinal PFD were studied in 23 albino rabbits (28 eyes). Using glass micropipettes (outer diameter of tip 100-120 microns), we injected 50-100 microliters PFD subretinally via the vitreous space. The same volume of BSS was injected into 18 control eyes. Eyes were monitored by indirect ophthalmoscopy and examined by light and electron microscopy at 1, 2 and 3 days, and 1, 2, 4 and 12 weeks. Progressive retinal detachments with newly formed retinal breaks in the inferior quadrants developed in 26 of 28 eyes. As early as 1 day postoperatively, subretinal PFD induced loss of outer and inner segments. Local retinal necrosis occurred in 4 eyes 5-7 days after surgery. A marked vacuole formation in retinal layers and PFD emulsification were regularly seen. The control eyes healed spontaneously. Toxic, mechanical and barrier effects may have caused the retinal damage. We advocate that all PFD be removed from the eye at surgery.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/BF00918847</identifier><identifier>PMID: 8486306</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Fluorocarbons - toxicity ; Injections ; Medical sciences ; Ophthalmology ; Photoreceptor Cells - ultrastructure ; Pigment Epithelium of Eye - ultrastructure ; Rabbits ; Retinal Degeneration - chemically induced ; Retinal Degeneration - pathology ; Retinal Detachment - chemically induced ; Retinal Detachment - pathology ; Retinal Perforations - chemically induced ; Retinal Perforations - pathology ; Retinopathies ; Vitreous Body</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 1993-04, Vol.231 (4), p.233-237</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-3c93cdf5ae7bf01e3e29370d48eabbb9e716866edb5044b76c44c6644e78dc83</citedby><cites>FETCH-LOGICAL-c311t-3c93cdf5ae7bf01e3e29370d48eabbb9e716866edb5044b76c44c6644e78dc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4726590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8486306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERGLIN, L</creatorcontrib><creatorcontrib>REN, J</creatorcontrib><creatorcontrib>ALGVERE, P. V</creatorcontrib><title>Retinal detachment and degeneration in response to subretinal perfluorodecalin in rabbit eyes</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Perfluorocarbon liquids, including perfluorodecalin (PFD), are useful intraoperative tools in complicated vitreoretinal surgery, such as for giant retinal tears, PVR and intraocular foreign bodies. Due to its high specific gravity (1.91 g/cm3) subretinal complications of PFD may occur. The consequences of subretinal PFD were studied in 23 albino rabbits (28 eyes). Using glass micropipettes (outer diameter of tip 100-120 microns), we injected 50-100 microliters PFD subretinally via the vitreous space. The same volume of BSS was injected into 18 control eyes. Eyes were monitored by indirect ophthalmoscopy and examined by light and electron microscopy at 1, 2 and 3 days, and 1, 2, 4 and 12 weeks. Progressive retinal detachments with newly formed retinal breaks in the inferior quadrants developed in 26 of 28 eyes. As early as 1 day postoperatively, subretinal PFD induced loss of outer and inner segments. Local retinal necrosis occurred in 4 eyes 5-7 days after surgery. A marked vacuole formation in retinal layers and PFD emulsification were regularly seen. The control eyes healed spontaneously. Toxic, mechanical and barrier effects may have caused the retinal damage. We advocate that all PFD be removed from the eye at surgery.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fluorocarbons - toxicity</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Photoreceptor Cells - ultrastructure</subject><subject>Pigment Epithelium of Eye - ultrastructure</subject><subject>Rabbits</subject><subject>Retinal Degeneration - chemically induced</subject><subject>Retinal Degeneration - pathology</subject><subject>Retinal Detachment - chemically induced</subject><subject>Retinal Detachment - pathology</subject><subject>Retinal Perforations - chemically induced</subject><subject>Retinal Perforations - pathology</subject><subject>Retinopathies</subject><subject>Vitreous Body</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5eBKis9nN7uaoxapQEKSHXiTsx0Qj6Sbspof-eyMJ9TQM7zMvzEPINYV7CiAfnlYABVWKyxMyp5zlqYRse0rmIDOaKpZtz8lFjD8AMIR0RmaKK8FAzMnnB_a1103isNf2e4e-T7R3w_qFHoPu69YntU8Cxq71EZO-TeLehOmqw1A1-za0Dq1u6hHVxtR9ggeMl-Ss0k3Eq2kuyGb1vFm-puv3l7fl4zq1jNI-ZbZg1lW5RmkqoMgwK5gExxUOXaZASYUSAp3JgXMjheXcCsE5SuWsYgtyN9ba0MYYsCq7UO90OJQUyj9D5b-hAb4Z4W5vduiO6KRkyG-nXMfhpypob-t4xLjMRF4A-wXR0W8t</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>BERGLIN, L</creator><creator>REN, J</creator><creator>ALGVERE, P. V</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19930401</creationdate><title>Retinal detachment and degeneration in response to subretinal perfluorodecalin in rabbit eyes</title><author>BERGLIN, L ; REN, J ; ALGVERE, P. V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-3c93cdf5ae7bf01e3e29370d48eabbb9e716866edb5044b76c44c6644e78dc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fluorocarbons - toxicity</topic><topic>Injections</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Photoreceptor Cells - ultrastructure</topic><topic>Pigment Epithelium of Eye - ultrastructure</topic><topic>Rabbits</topic><topic>Retinal Degeneration - chemically induced</topic><topic>Retinal Degeneration - pathology</topic><topic>Retinal Detachment - chemically induced</topic><topic>Retinal Detachment - pathology</topic><topic>Retinal Perforations - chemically induced</topic><topic>Retinal Perforations - pathology</topic><topic>Retinopathies</topic><topic>Vitreous Body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERGLIN, L</creatorcontrib><creatorcontrib>REN, J</creatorcontrib><creatorcontrib>ALGVERE, P. V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERGLIN, L</au><au>REN, J</au><au>ALGVERE, P. V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal detachment and degeneration in response to subretinal perfluorodecalin in rabbit eyes</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>231</volume><issue>4</issue><spage>233</spage><epage>237</epage><pages>233-237</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><coden>GACODL</coden><abstract>Perfluorocarbon liquids, including perfluorodecalin (PFD), are useful intraoperative tools in complicated vitreoretinal surgery, such as for giant retinal tears, PVR and intraocular foreign bodies. Due to its high specific gravity (1.91 g/cm3) subretinal complications of PFD may occur. The consequences of subretinal PFD were studied in 23 albino rabbits (28 eyes). Using glass micropipettes (outer diameter of tip 100-120 microns), we injected 50-100 microliters PFD subretinally via the vitreous space. The same volume of BSS was injected into 18 control eyes. Eyes were monitored by indirect ophthalmoscopy and examined by light and electron microscopy at 1, 2 and 3 days, and 1, 2, 4 and 12 weeks. Progressive retinal detachments with newly formed retinal breaks in the inferior quadrants developed in 26 of 28 eyes. As early as 1 day postoperatively, subretinal PFD induced loss of outer and inner segments. Local retinal necrosis occurred in 4 eyes 5-7 days after surgery. A marked vacuole formation in retinal layers and PFD emulsification were regularly seen. The control eyes healed spontaneously. Toxic, mechanical and barrier effects may have caused the retinal damage. We advocate that all PFD be removed from the eye at surgery.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8486306</pmid><doi>10.1007/BF00918847</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 1993-04, Vol.231 (4), p.233-237 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00918847 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Fluorocarbons - toxicity Injections Medical sciences Ophthalmology Photoreceptor Cells - ultrastructure Pigment Epithelium of Eye - ultrastructure Rabbits Retinal Degeneration - chemically induced Retinal Degeneration - pathology Retinal Detachment - chemically induced Retinal Detachment - pathology Retinal Perforations - chemically induced Retinal Perforations - pathology Retinopathies Vitreous Body |
| title | Retinal detachment and degeneration in response to subretinal perfluorodecalin in rabbit eyes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T23%3A26%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinal%20detachment%20and%20degeneration%20in%20response%20to%20subretinal%20perfluorodecalin%20in%20rabbit%20eyes&rft.jtitle=Graefe's%20archive%20for%20clinical%20and%20experimental%20ophthalmology&rft.au=BERGLIN,%20L&rft.date=1993-04-01&rft.volume=231&rft.issue=4&rft.spage=233&rft.epage=237&rft.pages=233-237&rft.issn=0721-832X&rft.eissn=1435-702X&rft.coden=GACODL&rft_id=info:doi/10.1007/BF00918847&rft_dat=%3Cpubmed_cross%3E8486306%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/8486306&rfr_iscdi=true |