Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents
Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elic...
Gespeichert in:
| Veröffentlicht in: | Inflammation 1986-09, Vol.10 (3), p.233-242 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 242 |
|---|---|
| container_issue | 3 |
| container_start_page | 233 |
| container_title | Inflammation |
| container_volume | 10 |
| creator | AVIRAM, I SHARABANI, M |
| description | Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elicited NADPH oxidase activity were lowered by the treatment, the activation parameters, namely lag times of the reaction, were not altered. The protection by Con A against blockade by cross-linkers developed concomitantly to the activation of NADPH oxidase and indicated redistribution of cross-linker-susceptible cellular components responsible for activation with PMA. The identity of these components is discussed. |
| doi_str_mv | 10.1007/BF00916119 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00916119</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3017856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c239t-a8b0f33096c2a2c508a4b436f0dbf9fe833a16fe6bf02f756b51c0baf03c90f33</originalsourceid><addsrcrecordid>eNpFkLFOwzAURS0EKqWwsCN5YEIKPMeNE4-looBUiQXmyHbs1uA6ke0gdeDfaWhVpjecc6-eLkLXBO4JQPnwuADghBHCT9CYFCXN8qJkp2gMlEFGOS_P0UWMnwBQ8YqO0IgCKauCjdHPTCX7LZJtfdboTvtG-4SDbmxMwcp-ALg1WGnneicCVu2ma_1Oili4pEPEsY9Kd8lK62zaDvK63wiPve5TaLu1dRGnFqvQxpg567-sX2GxGiou0ZkRLuqrw52gj8XT-_wlW749v85ny0zllKdMVBIMpcCZykWuCqjEVE4pM9BIw42uKBWEGc2kgdyUBZMFUSCFAar4kJygu33v3xNBm7oLdiPCtiZQDxPW_xPu5Ju93PVyo5ujethsx28PXEQlnAnCKxuPWskrRuiU_gJtD3yE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>AVIRAM, I ; SHARABANI, M</creator><creatorcontrib>AVIRAM, I ; SHARABANI, M</creatorcontrib><description>Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elicited NADPH oxidase activity were lowered by the treatment, the activation parameters, namely lag times of the reaction, were not altered. The protection by Con A against blockade by cross-linkers developed concomitantly to the activation of NADPH oxidase and indicated redistribution of cross-linker-susceptible cellular components responsible for activation with PMA. The identity of these components is discussed.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/BF00916119</identifier><identifier>PMID: 3017856</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Biological and medical sciences ; Cell physiology ; Concanavalin A - pharmacology ; Cross-Linking Reagents - pharmacology ; Enzyme Activation - drug effects ; Fundamental and applied biological sciences. Psychology ; Humans ; Lymphocyte Activation - drug effects ; Membrane Proteins - metabolism ; Molecular and cellular biology ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; NADH, NADPH Oxidoreductases - metabolism ; NADPH Oxidases ; Neutrophils - drug effects ; Responses to growth factors, tumor promotors, other factors ; Superoxides - biosynthesis ; Tetradecanoylphorbol Acetate - pharmacology</subject><ispartof>Inflammation, 1986-09, Vol.10 (3), p.233-242</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-a8b0f33096c2a2c508a4b436f0dbf9fe833a16fe6bf02f756b51c0baf03c90f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7986134$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3017856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AVIRAM, I</creatorcontrib><creatorcontrib>SHARABANI, M</creatorcontrib><title>Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents</title><title>Inflammation</title><addtitle>Inflammation</addtitle><description>Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elicited NADPH oxidase activity were lowered by the treatment, the activation parameters, namely lag times of the reaction, were not altered. The protection by Con A against blockade by cross-linkers developed concomitantly to the activation of NADPH oxidase and indicated redistribution of cross-linker-susceptible cellular components responsible for activation with PMA. The identity of these components is discussed.</description><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Concanavalin A - pharmacology</subject><subject>Cross-Linking Reagents - pharmacology</subject><subject>Enzyme Activation - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Membrane Proteins - metabolism</subject><subject>Molecular and cellular biology</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>NADH, NADPH Oxidoreductases - metabolism</subject><subject>NADPH Oxidases</subject><subject>Neutrophils - drug effects</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Superoxides - biosynthesis</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLFOwzAURS0EKqWwsCN5YEIKPMeNE4-looBUiQXmyHbs1uA6ke0gdeDfaWhVpjecc6-eLkLXBO4JQPnwuADghBHCT9CYFCXN8qJkp2gMlEFGOS_P0UWMnwBQ8YqO0IgCKauCjdHPTCX7LZJtfdboTvtG-4SDbmxMwcp-ALg1WGnneicCVu2ma_1Oili4pEPEsY9Kd8lK62zaDvK63wiPve5TaLu1dRGnFqvQxpg567-sX2GxGiou0ZkRLuqrw52gj8XT-_wlW749v85ny0zllKdMVBIMpcCZykWuCqjEVE4pM9BIw42uKBWEGc2kgdyUBZMFUSCFAar4kJygu33v3xNBm7oLdiPCtiZQDxPW_xPu5Ju93PVyo5ujethsx28PXEQlnAnCKxuPWskrRuiU_gJtD3yE</recordid><startdate>19860901</startdate><enddate>19860901</enddate><creator>AVIRAM, I</creator><creator>SHARABANI, M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19860901</creationdate><title>Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents</title><author>AVIRAM, I ; SHARABANI, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-a8b0f33096c2a2c508a4b436f0dbf9fe833a16fe6bf02f756b51c0baf03c90f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Concanavalin A - pharmacology</topic><topic>Cross-Linking Reagents - pharmacology</topic><topic>Enzyme Activation - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Membrane Proteins - metabolism</topic><topic>Molecular and cellular biology</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</topic><topic>NADH, NADPH Oxidoreductases - metabolism</topic><topic>NADPH Oxidases</topic><topic>Neutrophils - drug effects</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Superoxides - biosynthesis</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AVIRAM, I</creatorcontrib><creatorcontrib>SHARABANI, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AVIRAM, I</au><au>SHARABANI, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents</atitle><jtitle>Inflammation</jtitle><addtitle>Inflammation</addtitle><date>1986-09-01</date><risdate>1986</risdate><volume>10</volume><issue>3</issue><spage>233</spage><epage>242</epage><pages>233-242</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elicited NADPH oxidase activity were lowered by the treatment, the activation parameters, namely lag times of the reaction, were not altered. The protection by Con A against blockade by cross-linkers developed concomitantly to the activation of NADPH oxidase and indicated redistribution of cross-linker-susceptible cellular components responsible for activation with PMA. The identity of these components is discussed.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>3017856</pmid><doi>10.1007/BF00916119</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3997 |
| ispartof | Inflammation, 1986-09, Vol.10 (3), p.233-242 |
| issn | 0360-3997 1573-2576 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00916119 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Cell physiology Concanavalin A - pharmacology Cross-Linking Reagents - pharmacology Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Humans Lymphocyte Activation - drug effects Membrane Proteins - metabolism Molecular and cellular biology N-Formylmethionine Leucyl-Phenylalanine - pharmacology NADH, NADPH Oxidoreductases - metabolism NADPH Oxidases Neutrophils - drug effects Responses to growth factors, tumor promotors, other factors Superoxides - biosynthesis Tetradecanoylphorbol Acetate - pharmacology |
| title | Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T05%3A39%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Activation-dependent%20redistribution%20of%20cellular%20components%20alters%20susceptibility%20of%20human%20neutrophils%20to%20cross-linking%20agents&rft.jtitle=Inflammation&rft.au=AVIRAM,%20I&rft.date=1986-09-01&rft.volume=10&rft.issue=3&rft.spage=233&rft.epage=242&rft.pages=233-242&rft.issn=0360-3997&rft.eissn=1573-2576&rft.coden=INFLD4&rft_id=info:doi/10.1007/BF00916119&rft_dat=%3Cpubmed_cross%3E3017856%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/3017856&rfr_iscdi=true |