Potentiated nephrotoxicity of cisplatin when combined with amikacin comparing young and adult rats

We compared the nephrotoxic interaction between cisplatin (CP) and amikacin (AM) in young and adult rats, using different dosage combinations. Following a single i.v. dose of CP, AM was administered s.c. for 14 days. The dose of CP was chosen to cause a 20%-50% fall in the glomerular filtration rate...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 1989-07, Vol.3 (3), p.290-295
Hauptverfasser:	JONGEJAN, H. T. M, PROVOOST, A. P, MOLENAAR, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Amikacin - toxicity Animals Biological and medical sciences Cisplatin - toxicity Drug Synergism Drug toxicity and drugs side effects treatment Glomerular Filtration Rate - drug effects Kidney - drug effects Kidney - physiopathology Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Toxicity: urogenital system
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