Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours
One of the main problems regarding the follow-up of patients with brain tumours treated with radiotherapy is the distinction between radiation necrosis and tumour relapse. In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 1996-03, Vol.23 (3), p.308-311 |
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| container_title | European Journal of Nuclear Medicine |
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| creator | MAFFIOLI, L GASPARINI, M CHITI, A GRAMAGLIA, A MONGIOJ, V POZZI, A BOMBARDIERI, E |
| description | One of the main problems regarding the follow-up of patients with brain tumours treated with radiotherapy is the distinction between radiation necrosis and tumour relapse. In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single-photon emission tomography (SPET) with technetium-99m-sestamibi in cases where CT scan was not conclusive. The absence of tracer uptake in normal brain, the sharp uptake in neoplastic tissue, and the favourable physical properties of technetium make the scintigraphic method particularly accurate. We therefore propose the association of CT scan with 99mTc-sestamibi brain SPET in the follow-up of patients in whom a distinction between radiation necrosis and active disease is needed for an adequate therapeutic decision. |
| doi_str_mv | 10.1007/BF00837629 |
| format | Article |
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In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single-photon emission tomography (SPET) with technetium-99m-sestamibi in cases where CT scan was not conclusive. The absence of tracer uptake in normal brain, the sharp uptake in neoplastic tissue, and the favourable physical properties of technetium make the scintigraphic method particularly accurate. We therefore propose the association of CT scan with 99mTc-sestamibi brain SPET in the follow-up of patients in whom a distinction between radiation necrosis and active disease is needed for an adequate therapeutic decision.</description><identifier>ISSN: 0340-6997</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/BF00837629</identifier><identifier>PMID: 8599962</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - physiopathology ; Child ; Humans ; Medical sciences ; Middle Aged ; Neurology ; Recurrence ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon ; Tumors of the nervous system. 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In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single-photon emission tomography (SPET) with technetium-99m-sestamibi in cases where CT scan was not conclusive. The absence of tracer uptake in normal brain, the sharp uptake in neoplastic tissue, and the favourable physical properties of technetium make the scintigraphic method particularly accurate. We therefore propose the association of CT scan with 99mTc-sestamibi brain SPET in the follow-up of patients in whom a distinction between radiation necrosis and active disease is needed for an adequate therapeutic decision.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - physiopathology</subject><subject>Child</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Recurrence</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0340-6997</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtLxDAYxIMouj4u3oUcxINQTZq0SY66-ALBi55Lmsc20jY1SZW9-acbcVlP38fMj4EZAE4xusIIsevbe4Q4YXUpdsAC11gUDHGxCxaIUFTUQrADcBjjO0KIUlLtg31eCSHqcgG-l70bnZI9DL430FuYjOpGk9w8FEIMMJqY5OBaB6MbV70pps4nP0IzuBhdfpIf_CrIqVtDl-VP2c8yZRROwaRgZDIaTlkxY4rwy6UOtkFmMs2Dn0M8BntW9tGcbO4ReLu_e10-Fs8vD0_Lm-dCEYxTYavWYq2IEpyaqkRYU1RRyalQjGpek1JzznUpbU1o22pbUoqlbWXVMqJLQY7AxV_uFPzHnEs1uYAyfS9H4-fYMCZqyhnO4OUfqIKPMRjbTMENMqwbjJrfuZv_uTN8tkmd28HoLbrZN_vnG1_GPLINclQubjGCSlFhTn4AQkmJ7g</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>MAFFIOLI, L</creator><creator>GASPARINI, M</creator><creator>CHITI, A</creator><creator>GRAMAGLIA, A</creator><creator>MONGIOJ, V</creator><creator>POZZI, A</creator><creator>BOMBARDIERI, E</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours</title><author>MAFFIOLI, L ; GASPARINI, M ; CHITI, A ; GRAMAGLIA, A ; MONGIOJ, V ; POZZI, A ; BOMBARDIERI, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-f5bf1dc3c984e5201d4054a849c74d8632d888d2af634bbdf2441afba5b73d293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - physiopathology</topic><topic>Child</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Recurrence</topic><topic>Technetium Tc 99m Sestamibi</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAFFIOLI, L</creatorcontrib><creatorcontrib>GASPARINI, M</creatorcontrib><creatorcontrib>CHITI, A</creatorcontrib><creatorcontrib>GRAMAGLIA, A</creatorcontrib><creatorcontrib>MONGIOJ, V</creatorcontrib><creatorcontrib>POZZI, A</creatorcontrib><creatorcontrib>BOMBARDIERI, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAFFIOLI, L</au><au>GASPARINI, M</au><au>CHITI, A</au><au>GRAMAGLIA, A</au><au>MONGIOJ, V</au><au>POZZI, A</au><au>BOMBARDIERI, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>23</volume><issue>3</issue><spage>308</spage><epage>311</epage><pages>308-311</pages><issn>0340-6997</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>One of the main problems regarding the follow-up of patients with brain tumours treated with radiotherapy is the distinction between radiation necrosis and tumour relapse. In many cases computed tomography (CT) scan is unable to distinguish between the two. We assessed the usefulness of brain single-photon emission tomography (SPET) with technetium-99m-sestamibi in cases where CT scan was not conclusive. The absence of tracer uptake in normal brain, the sharp uptake in neoplastic tissue, and the favourable physical properties of technetium make the scintigraphic method particularly accurate. We therefore propose the association of CT scan with 99mTc-sestamibi brain SPET in the follow-up of patients in whom a distinction between radiation necrosis and active disease is needed for an adequate therapeutic decision.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8599962</pmid><doi>10.1007/BF00837629</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0340-6997 |
| ispartof | European Journal of Nuclear Medicine, 1996-03, Vol.23 (3), p.308-311 |
| issn | 0340-6997 1619-7089 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Brain Neoplasms - diagnostic imaging Brain Neoplasms - physiopathology Child Humans Medical sciences Middle Aged Neurology Recurrence Technetium Tc 99m Sestamibi Tomography, Emission-Computed, Single-Photon Tumors of the nervous system. Phacomatoses |
| title | Clinical role of technetium-99m sestamibi single-photon emission tomography in evaluating pretreated patients with brain tumours |
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