Role of cellular defense against hydrogen peroxide-induced inhibition of myocyte respiration

Hydrogen peroxide (H2O2) serves as a precursor for highly reactive oxygen intermediates. However, the respiratory function of myocytes is relatively resistant to exogenously administered H2O2. In this study, we examined whether or not the reduction of cellular defense increases the toxicity of H2O2....

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Veröffentlicht in:	Basic research in cardiology 1992-05, Vol.87 (3), p.239-249
Hauptverfasser:	Konno, N, Kako, K J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitrole Animals Cell Survival - drug effects Cytosol - physiology Hydrogen Peroxide - pharmacology Male Membrane Potentials - drug effects Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Oxidative Phosphorylation - drug effects Oxygen Consumption - drug effects Rats Rats, Inbred Strains Saponins Sarcolemma - physiology
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