Quantitation of myocardial iodine-123 MIBG uptake in SPET studies : a new approach using the left ventricular cavity and a blood sample as a reference
In patients with chronic heart failure increased sympathetic activity is related to unfavourable prognosis. Since myocardial iodine-123 metaiodobenzylguanidine ([123I]MIBG) uptake is related to myocardial noradrenaline content, i.e. cardiac sympathetic activity, measurement of myocardial [123I]MIBG...
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| Veröffentlicht in: | European Journal of Nuclear Medicine 1995-10, Vol.22 (10), p.1149-1154 |
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| creator | AERNOUT SOMSEN, G BORM, J. J. J DE MILLIANO, P. A. R VAN VLIES, B DUBOIS, E. A VAN ROYEN, E. A |
| description | In patients with chronic heart failure increased sympathetic activity is related to unfavourable prognosis. Since myocardial iodine-123 metaiodobenzylguanidine ([123I]MIBG) uptake is related to myocardial noradrenaline content, i.e. cardiac sympathetic activity, measurement of myocardial [123I]MIBG uptake may be of clinical use in determining prognosis or the effect of pharmacological intervention in these patients. The aim of the present study was to evaluate a new method to quantitate myocardial [123I]MIBG uptake with respect to reproducibility and accuracy. Eighteen [123I]MIBG planar and single-photon emission tomographic (SPET) studies of patients with chronic heart failure were evaluated. Myocardial uptake was calculated from the myocardial (MYO) to left ventricular cavity (C) count density ratio and the 123I activity in a blood sample. This was performed employing planar LAO images, a single-slice SPET method using the midventricular myocardial short-axis slice, and finally a multi-slice SPET method analysing semi-automatically drawn volumes of interest (VOIs). The accuracy of the multi-slice SPET method was verified using a cardiac phantom. The planar method was found to be reproducible [intra- and interobserver coefficients of variation (IACV and IRCV) were 0.025 and 0.012 respectively] but the mean MYO/C count density ratio was only 1.31 +/- 0.16 as a consequence of overprojection. For the single-slice SPET method IACV was 0.2 and IRCV was 0.13, representing poor reproducibility. For the multi-slice SPET method IACV was 0.051, IRCV was 0.047 and the mean MYO/C count density ratio was 5.4 +/- 2.42. Accuracy was 81% at a true MYO/C count density ratio of 6 in the phantom. It is concluded that the multi-slice SPET method using the left ventricular cavity VOI and a blood sample as a reference is a reproducible and accurate method for assessing myocardial [123I]MIBG uptake. |
| doi_str_mv | 10.1007/BF00800597 |
| format | Article |
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J. J ; DE MILLIANO, P. A. R ; VAN VLIES, B ; DUBOIS, E. A ; VAN ROYEN, E. A</creator><creatorcontrib>AERNOUT SOMSEN, G ; BORM, J. J. J ; DE MILLIANO, P. A. R ; VAN VLIES, B ; DUBOIS, E. A ; VAN ROYEN, E. A</creatorcontrib><description>In patients with chronic heart failure increased sympathetic activity is related to unfavourable prognosis. Since myocardial iodine-123 metaiodobenzylguanidine ([123I]MIBG) uptake is related to myocardial noradrenaline content, i.e. cardiac sympathetic activity, measurement of myocardial [123I]MIBG uptake may be of clinical use in determining prognosis or the effect of pharmacological intervention in these patients. The aim of the present study was to evaluate a new method to quantitate myocardial [123I]MIBG uptake with respect to reproducibility and accuracy. Eighteen [123I]MIBG planar and single-photon emission tomographic (SPET) studies of patients with chronic heart failure were evaluated. Myocardial uptake was calculated from the myocardial (MYO) to left ventricular cavity (C) count density ratio and the 123I activity in a blood sample. This was performed employing planar LAO images, a single-slice SPET method using the midventricular myocardial short-axis slice, and finally a multi-slice SPET method analysing semi-automatically drawn volumes of interest (VOIs). The accuracy of the multi-slice SPET method was verified using a cardiac phantom. The planar method was found to be reproducible [intra- and interobserver coefficients of variation (IACV and IRCV) were 0.025 and 0.012 respectively] but the mean MYO/C count density ratio was only 1.31 +/- 0.16 as a consequence of overprojection. For the single-slice SPET method IACV was 0.2 and IRCV was 0.13, representing poor reproducibility. For the multi-slice SPET method IACV was 0.051, IRCV was 0.047 and the mean MYO/C count density ratio was 5.4 +/- 2.42. Accuracy was 81% at a true MYO/C count density ratio of 6 in the phantom. It is concluded that the multi-slice SPET method using the left ventricular cavity VOI and a blood sample as a reference is a reproducible and accurate method for assessing myocardial [123I]MIBG uptake.</description><identifier>ISSN: 0340-6997</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/BF00800597</identifier><identifier>PMID: 8542899</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>3-Iodobenzylguanidine ; Biological and medical sciences ; Cardiovascular system ; Evaluation Studies as Topic ; Female ; Heart - diagnostic imaging ; Heart - innervation ; Heart Failure - diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Iodine Radioisotopes ; Iodobenzenes ; Male ; Medical sciences ; Middle Aged ; Observer Variation ; Phantoms, Imaging ; Radionuclide investigations ; Reproducibility of Results ; Sympatholytics ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>European Journal of Nuclear Medicine, 1995-10, Vol.22 (10), p.1149-1154</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-a20ed17b1b724b039b7aa5222cbffcbf8714044369e5973483be5a64d4d200b83</citedby><cites>FETCH-LOGICAL-c226t-a20ed17b1b724b039b7aa5222cbffcbf8714044369e5973483be5a64d4d200b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3684158$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8542899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AERNOUT SOMSEN, G</creatorcontrib><creatorcontrib>BORM, J. J. J</creatorcontrib><creatorcontrib>DE MILLIANO, P. A. R</creatorcontrib><creatorcontrib>VAN VLIES, B</creatorcontrib><creatorcontrib>DUBOIS, E. A</creatorcontrib><creatorcontrib>VAN ROYEN, E. A</creatorcontrib><title>Quantitation of myocardial iodine-123 MIBG uptake in SPET studies : a new approach using the left ventricular cavity and a blood sample as a reference</title><title>European Journal of Nuclear Medicine</title><addtitle>Eur J Nucl Med</addtitle><description>In patients with chronic heart failure increased sympathetic activity is related to unfavourable prognosis. Since myocardial iodine-123 metaiodobenzylguanidine ([123I]MIBG) uptake is related to myocardial noradrenaline content, i.e. cardiac sympathetic activity, measurement of myocardial [123I]MIBG uptake may be of clinical use in determining prognosis or the effect of pharmacological intervention in these patients. The aim of the present study was to evaluate a new method to quantitate myocardial [123I]MIBG uptake with respect to reproducibility and accuracy. Eighteen [123I]MIBG planar and single-photon emission tomographic (SPET) studies of patients with chronic heart failure were evaluated. Myocardial uptake was calculated from the myocardial (MYO) to left ventricular cavity (C) count density ratio and the 123I activity in a blood sample. This was performed employing planar LAO images, a single-slice SPET method using the midventricular myocardial short-axis slice, and finally a multi-slice SPET method analysing semi-automatically drawn volumes of interest (VOIs). The accuracy of the multi-slice SPET method was verified using a cardiac phantom. The planar method was found to be reproducible [intra- and interobserver coefficients of variation (IACV and IRCV) were 0.025 and 0.012 respectively] but the mean MYO/C count density ratio was only 1.31 +/- 0.16 as a consequence of overprojection. For the single-slice SPET method IACV was 0.2 and IRCV was 0.13, representing poor reproducibility. For the multi-slice SPET method IACV was 0.051, IRCV was 0.047 and the mean MYO/C count density ratio was 5.4 +/- 2.42. Accuracy was 81% at a true MYO/C count density ratio of 6 in the phantom. It is concluded that the multi-slice SPET method using the left ventricular cavity VOI and a blood sample as a reference is a reproducible and accurate method for assessing myocardial [123I]MIBG uptake.</description><subject>3-Iodobenzylguanidine</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - innervation</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodine Radioisotopes</subject><subject>Iodobenzenes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Phantoms, Imaging</subject><subject>Radionuclide investigations</subject><subject>Reproducibility of Results</subject><subject>Sympatholytics</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>0340-6997</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFv1jAMhiPENL4NLtyRfEAckDqcNG1abmzaxqRNgBjnyk1dFmjTLkmHvj-y30unfdoOliX78avXthBvJR5JRPPp-AyxQixq80JsZCnrzGBVvxQbzDVmZV2bV-Igxj-IqHVe7Iv9qtCqquuNuP-xkE8uUXKTh6mHcTtZCp2jAdzUOc-ZVDlcXRyfwzIn-svgPPz8fnoNMS2d4wifgcDzP6B5DhPZG1ii878h3TAM3Ce4Y5-Cs8tAASzdubQF8t061A7T1EGkcR4YKK6VwD0H9pZfi72ehshvdvlQ_Do7vT75ml1-O784-XKZWaXKlJFC7qRpZWuUbjGvW0NUKKVs2_drVEbqh5XLmtfj5LrKWy6o1J3uFGJb5Yfiw6Puav124Zia0UXLw0CepyU2xpjCoDIr-PERtGGKcfXZzMGNFLaNxObhCc3zE1b43U51aUfuntDd1df--12foqWhD-Sti09YXlZaFlX-H1phjhg</recordid><startdate>199510</startdate><enddate>199510</enddate><creator>AERNOUT SOMSEN, G</creator><creator>BORM, J. J. J</creator><creator>DE MILLIANO, P. A. R</creator><creator>VAN VLIES, B</creator><creator>DUBOIS, E. A</creator><creator>VAN ROYEN, E. A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199510</creationdate><title>Quantitation of myocardial iodine-123 MIBG uptake in SPET studies : a new approach using the left ventricular cavity and a blood sample as a reference</title><author>AERNOUT SOMSEN, G ; BORM, J. J. J ; DE MILLIANO, P. A. R ; VAN VLIES, B ; DUBOIS, E. A ; VAN ROYEN, E. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-a20ed17b1b724b039b7aa5222cbffcbf8714044369e5973483be5a64d4d200b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>3-Iodobenzylguanidine</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - innervation</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodine Radioisotopes</topic><topic>Iodobenzenes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Phantoms, Imaging</topic><topic>Radionuclide investigations</topic><topic>Reproducibility of Results</topic><topic>Sympatholytics</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AERNOUT SOMSEN, G</creatorcontrib><creatorcontrib>BORM, J. J. J</creatorcontrib><creatorcontrib>DE MILLIANO, P. A. R</creatorcontrib><creatorcontrib>VAN VLIES, B</creatorcontrib><creatorcontrib>DUBOIS, E. A</creatorcontrib><creatorcontrib>VAN ROYEN, E. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AERNOUT SOMSEN, G</au><au>BORM, J. J. J</au><au>DE MILLIANO, P. A. R</au><au>VAN VLIES, B</au><au>DUBOIS, E. A</au><au>VAN ROYEN, E. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitation of myocardial iodine-123 MIBG uptake in SPET studies : a new approach using the left ventricular cavity and a blood sample as a reference</atitle><jtitle>European Journal of Nuclear Medicine</jtitle><addtitle>Eur J Nucl Med</addtitle><date>1995-10</date><risdate>1995</risdate><volume>22</volume><issue>10</issue><spage>1149</spage><epage>1154</epage><pages>1149-1154</pages><issn>0340-6997</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>In patients with chronic heart failure increased sympathetic activity is related to unfavourable prognosis. Since myocardial iodine-123 metaiodobenzylguanidine ([123I]MIBG) uptake is related to myocardial noradrenaline content, i.e. cardiac sympathetic activity, measurement of myocardial [123I]MIBG uptake may be of clinical use in determining prognosis or the effect of pharmacological intervention in these patients. The aim of the present study was to evaluate a new method to quantitate myocardial [123I]MIBG uptake with respect to reproducibility and accuracy. Eighteen [123I]MIBG planar and single-photon emission tomographic (SPET) studies of patients with chronic heart failure were evaluated. Myocardial uptake was calculated from the myocardial (MYO) to left ventricular cavity (C) count density ratio and the 123I activity in a blood sample. This was performed employing planar LAO images, a single-slice SPET method using the midventricular myocardial short-axis slice, and finally a multi-slice SPET method analysing semi-automatically drawn volumes of interest (VOIs). The accuracy of the multi-slice SPET method was verified using a cardiac phantom. The planar method was found to be reproducible [intra- and interobserver coefficients of variation (IACV and IRCV) were 0.025 and 0.012 respectively] but the mean MYO/C count density ratio was only 1.31 +/- 0.16 as a consequence of overprojection. For the single-slice SPET method IACV was 0.2 and IRCV was 0.13, representing poor reproducibility. For the multi-slice SPET method IACV was 0.051, IRCV was 0.047 and the mean MYO/C count density ratio was 5.4 +/- 2.42. Accuracy was 81% at a true MYO/C count density ratio of 6 in the phantom. It is concluded that the multi-slice SPET method using the left ventricular cavity VOI and a blood sample as a reference is a reproducible and accurate method for assessing myocardial [123I]MIBG uptake.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8542899</pmid><doi>10.1007/BF00800597</doi><tpages>6</tpages></addata></record> |
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| subjects | 3-Iodobenzylguanidine Biological and medical sciences Cardiovascular system Evaluation Studies as Topic Female Heart - diagnostic imaging Heart - innervation Heart Failure - diagnostic imaging Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Iodobenzenes Male Medical sciences Middle Aged Observer Variation Phantoms, Imaging Radionuclide investigations Reproducibility of Results Sympatholytics Tomography, Emission-Computed, Single-Photon - methods |
| title | Quantitation of myocardial iodine-123 MIBG uptake in SPET studies : a new approach using the left ventricular cavity and a blood sample as a reference |
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