Co-existence of two aneuploid stemlines in benign adenomas: a report of three cases with stemline heterogeneity
The co-existence of 2 or more aneuploid stemlines (DNA multiploidy) has been described in malignant human neoplasms and such cancers have often been found to be associated with a poor prognosis. Here 3 benign human adenomas with 2 co-existing aneuploid stemlines are described. Despite DNA stemline h...
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| Veröffentlicht in: | Virchows Archiv A Pathological Anatomy and Histopathology 1989, Vol.415 (2), p.175-180 |
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| container_title | Virchows Archiv A Pathological Anatomy and Histopathology |
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| creator | JOENSUU, H KLEMI, P. J ALANEN, K. A |
| description | The co-existence of 2 or more aneuploid stemlines (DNA multiploidy) has been described in malignant human neoplasms and such cancers have often been found to be associated with a poor prognosis. Here 3 benign human adenomas with 2 co-existing aneuploid stemlines are described. Despite DNA stemline heterogeneity and large DNA indices up to 2.8 none of the adenomas recurred or gave rise to metastases after a simple excision during the follow-up of 8, 10 and 11 years. Two adenomas were hormonally active. Marked cellular atypia and frequent mitoses were seen in 1 of the adenomas but the other 2 tumours had little atypia. The present cases indicate that DNA stemline heterogeneity may occur in benign adenomas, and not even the presence of 2 aneuploid stemlines with greatly increased nuclear DNA content can be regarded as a conclusive sign of malignancy. |
| doi_str_mv | 10.1007/BF00784356 |
| format | Article |
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The present cases indicate that DNA stemline heterogeneity may occur in benign adenomas, and not even the presence of 2 aneuploid stemlines with greatly increased nuclear DNA content can be regarded as a conclusive sign of malignancy.</description><identifier>ISSN: 0174-7398</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/BF00784356</identifier><identifier>PMID: 2500772</identifier><identifier>CODEN: VAAHDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adenoma - genetics ; Adenoma - pathology ; Adrenal Gland Neoplasms - genetics ; Adrenal Gland Neoplasms - pathology ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; Aneuploidy ; Biological and medical sciences ; Cell Nucleus - analysis ; DNA - analysis ; Endocrinopathies ; Female ; Flow Cytometry ; Humans ; Infant ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - pathology ; Parathyroid Neoplasms - genetics ; Parathyroid Neoplasms - pathology</subject><ispartof>Virchows Archiv A Pathological Anatomy and Histopathology, 1989, Vol.415 (2), p.175-180</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c186t-625b29df4d7441184e1f03147daf355aa4751483ef8a2b2ba6f825db56c34a313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19675607$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2500772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JOENSUU, H</creatorcontrib><creatorcontrib>KLEMI, P. J</creatorcontrib><creatorcontrib>ALANEN, K. A</creatorcontrib><title>Co-existence of two aneuploid stemlines in benign adenomas: a report of three cases with stemline heterogeneity</title><title>Virchows Archiv A Pathological Anatomy and Histopathology</title><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><description>The co-existence of 2 or more aneuploid stemlines (DNA multiploidy) has been described in malignant human neoplasms and such cancers have often been found to be associated with a poor prognosis. Here 3 benign human adenomas with 2 co-existing aneuploid stemlines are described. Despite DNA stemline heterogeneity and large DNA indices up to 2.8 none of the adenomas recurred or gave rise to metastases after a simple excision during the follow-up of 8, 10 and 11 years. Two adenomas were hormonally active. Marked cellular atypia and frequent mitoses were seen in 1 of the adenomas but the other 2 tumours had little atypia. The present cases indicate that DNA stemline heterogeneity may occur in benign adenomas, and not even the presence of 2 aneuploid stemlines with greatly increased nuclear DNA content can be regarded as a conclusive sign of malignancy.</description><subject>Adenoma - genetics</subject><subject>Adenoma - pathology</subject><subject>Adrenal Gland Neoplasms - genetics</subject><subject>Adrenal Gland Neoplasms - pathology</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - analysis</subject><subject>DNA - analysis</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Parathyroid Neoplasms - genetics</subject><subject>Parathyroid Neoplasms - pathology</subject><issn>0174-7398</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1Lw0AQxRdRaq1evAt70YMQ3c9s4k2LVaHgRc9hk8y2K8lu3U2o_e9NtbSXGZj3ew_mIXRJyR0lRN0_zYaZCS7TIzSmgrOEcaKO0ZhQJRLF8-wUncX4RYiUNJMjNGJycCg2Rn7qE_ixsQNXAfYGd2uPtYN-1Xhb4-HeNtZBxNbhEpxdOKxrcL7V8QFrHGDlQ_fnWwYAXOk4sGvbLfdWvIQOgl-AA9ttztGJ0U2Ei92eoM_Z88f0NZm_v7xNH-dJRbO0S1ImS5bXRtRKCEozAdQQToWqteFSai2UpCLjYDLNSlbq1GRM1qVMKy40p3yCbv5zV8F_9xC7orWxgqYZfvN9LFROZC7UFrz9B6vgYwxgilWwrQ6bgpJi225xaHeAr3apfdlCvUd3dQ769U7XsdKNCdpVNh4S81TJlCj-C54Ngf4</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>JOENSUU, H</creator><creator>KLEMI, P. 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Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Cell Nucleus - analysis</topic><topic>DNA - analysis</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Parathyroid Neoplasms - genetics</topic><topic>Parathyroid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JOENSUU, H</creatorcontrib><creatorcontrib>KLEMI, P. J</creatorcontrib><creatorcontrib>ALANEN, K. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-existence of two aneuploid stemlines in benign adenomas: a report of three cases with stemline heterogeneity</atitle><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><date>1989</date><risdate>1989</risdate><volume>415</volume><issue>2</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>0174-7398</issn><eissn>1432-2307</eissn><coden>VAAHDJ</coden><abstract>The co-existence of 2 or more aneuploid stemlines (DNA multiploidy) has been described in malignant human neoplasms and such cancers have often been found to be associated with a poor prognosis. Here 3 benign human adenomas with 2 co-existing aneuploid stemlines are described. Despite DNA stemline heterogeneity and large DNA indices up to 2.8 none of the adenomas recurred or gave rise to metastases after a simple excision during the follow-up of 8, 10 and 11 years. Two adenomas were hormonally active. Marked cellular atypia and frequent mitoses were seen in 1 of the adenomas but the other 2 tumours had little atypia. The present cases indicate that DNA stemline heterogeneity may occur in benign adenomas, and not even the presence of 2 aneuploid stemlines with greatly increased nuclear DNA content can be regarded as a conclusive sign of malignancy.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2500772</pmid><doi>10.1007/BF00784356</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0174-7398 |
| ispartof | Virchows Archiv A Pathological Anatomy and Histopathology, 1989, Vol.415 (2), p.175-180 |
| issn | 0174-7398 1432-2307 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00784356 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adenoma - genetics Adenoma - pathology Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - pathology Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Aneuploidy Biological and medical sciences Cell Nucleus - analysis DNA - analysis Endocrinopathies Female Flow Cytometry Humans Infant Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Parathyroid Neoplasms - genetics Parathyroid Neoplasms - pathology |
| title | Co-existence of two aneuploid stemlines in benign adenomas: a report of three cases with stemline heterogeneity |
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