Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumors
MAM-3 and MAM-6 antigens of human milk fat globule membrane were detected immunohistochemically in 93 cases of salivary gland tumours as well as in normal glands. The antigens were visualized in 10% formalin-fixed paraffin sections. MAM-3 (MoAbs 115G3, 67D11) antigen was distributed in intercalated...
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| Veröffentlicht in: | Virchows Archiv A Pathological Anatomy and Histopathology 1989, Vol.415 (6), p.509-521 |
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| container_title | Virchows Archiv A Pathological Anatomy and Histopathology |
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| creator | YAMADA, K TANAKA, T MORI, M TSUBURA, A MORII, S TSUBONE, M ANDO, C HILGERS, J |
| description | MAM-3 and MAM-6 antigens of human milk fat globule membrane were detected immunohistochemically in 93 cases of salivary gland tumours as well as in normal glands. The antigens were visualized in 10% formalin-fixed paraffin sections. MAM-3 (MoAbs 115G3, 67D11) antigen was distributed in intercalated and striated duct cells of the normal salivary glands, and in luminal tumour cells and squamous metaplastic cells of pleomorphic adenomas. In pleomorphic adenomas the frequency of positive staining with MoAb 67D11 (54/67; 80.6%) was higher than that with MoAb 115G3 (36/67; 53.7%). MAM-6 (MoAbs 115D8, 115F5) antigen was expressed in luminal and lateral borders of serous acinar cells and ductal of the normal glands, and also in luminal borders of tubulo-ductal and glandular structures of salivary gland tumours. Ductal basal cells were characterized by existence of positive staining for MAM-6 antigen, in adenolymphomas MAM-6 antigen was restricted to the basal tumour cells. Some mucous cells of mucoepidermoid tumours were stained specifically with MoAb 115G3, and epidermoid cells of mucoepidermoid carcinomas manifested MAM-6 antigen staining. Immunohistochemical localization of MAM-6 antigen resembled that of epithelial membrane antigen (EMA) detected with MoAb. |
| doi_str_mv | 10.1007/bf00718644 |
| format | Article |
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The antigens were visualized in 10% formalin-fixed paraffin sections. MAM-3 (MoAbs 115G3, 67D11) antigen was distributed in intercalated and striated duct cells of the normal salivary glands, and in luminal tumour cells and squamous metaplastic cells of pleomorphic adenomas. In pleomorphic adenomas the frequency of positive staining with MoAb 67D11 (54/67; 80.6%) was higher than that with MoAb 115G3 (36/67; 53.7%). MAM-6 (MoAbs 115D8, 115F5) antigen was expressed in luminal and lateral borders of serous acinar cells and ductal of the normal glands, and also in luminal borders of tubulo-ductal and glandular structures of salivary gland tumours. Ductal basal cells were characterized by existence of positive staining for MAM-6 antigen, in adenolymphomas MAM-6 antigen was restricted to the basal tumour cells. Some mucous cells of mucoepidermoid tumours were stained specifically with MoAb 115G3, and epidermoid cells of mucoepidermoid carcinomas manifested MAM-6 antigen staining. Immunohistochemical localization of MAM-6 antigen resembled that of epithelial membrane antigen (EMA) detected with MoAb.</description><identifier>ISSN: 0174-7398</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/bf00718644</identifier><identifier>PMID: 2508309</identifier><identifier>CODEN: VAAHDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Antibodies, Monoclonal - immunology ; Antigens, Neoplasm - metabolism ; Biological and medical sciences ; Humans ; Immunohistochemistry ; Medical sciences ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - metabolism ; Mucin-1 ; Otorhinolaryngology. Stomatology ; Salivary Gland Neoplasms - immunology ; Salivary Gland Neoplasms - metabolism ; Salivary Gland Neoplasms - pathology ; Salivary Glands - immunology ; Salivary Glands - metabolism ; Salivary Glands - pathology ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Virchows Archiv A Pathological Anatomy and Histopathology, 1989, Vol.415 (6), p.509-521</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-252b324d35d611103c803ec1a92ae28785d8ce8d96750ba4c387aeadc184ffe23</citedby><cites>FETCH-LOGICAL-c340t-252b324d35d611103c803ec1a92ae28785d8ce8d96750ba4c387aeadc184ffe23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6773529$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2508309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMADA, K</creatorcontrib><creatorcontrib>TANAKA, T</creatorcontrib><creatorcontrib>MORI, M</creatorcontrib><creatorcontrib>TSUBURA, A</creatorcontrib><creatorcontrib>MORII, S</creatorcontrib><creatorcontrib>TSUBONE, M</creatorcontrib><creatorcontrib>ANDO, C</creatorcontrib><creatorcontrib>HILGERS, J</creatorcontrib><title>Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumors</title><title>Virchows Archiv A Pathological Anatomy and Histopathology</title><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><description>MAM-3 and MAM-6 antigens of human milk fat globule membrane were detected immunohistochemically in 93 cases of salivary gland tumours as well as in normal glands. The antigens were visualized in 10% formalin-fixed paraffin sections. MAM-3 (MoAbs 115G3, 67D11) antigen was distributed in intercalated and striated duct cells of the normal salivary glands, and in luminal tumour cells and squamous metaplastic cells of pleomorphic adenomas. In pleomorphic adenomas the frequency of positive staining with MoAb 67D11 (54/67; 80.6%) was higher than that with MoAb 115G3 (36/67; 53.7%). MAM-6 (MoAbs 115D8, 115F5) antigen was expressed in luminal and lateral borders of serous acinar cells and ductal of the normal glands, and also in luminal borders of tubulo-ductal and glandular structures of salivary gland tumours. Ductal basal cells were characterized by existence of positive staining for MAM-6 antigen, in adenolymphomas MAM-6 antigen was restricted to the basal tumour cells. Some mucous cells of mucoepidermoid tumours were stained specifically with MoAb 115G3, and epidermoid cells of mucoepidermoid carcinomas manifested MAM-6 antigen staining. Immunohistochemical localization of MAM-6 antigen resembled that of epithelial membrane antigen (EMA) detected with MoAb.</description><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, Neoplasm - metabolism</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Mucin-1</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Salivary Gland Neoplasms - immunology</subject><subject>Salivary Gland Neoplasms - metabolism</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Glands - immunology</subject><subject>Salivary Glands - metabolism</subject><subject>Salivary Glands - pathology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0174-7398</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1Lw0AUxBdRaq1evAs5iAchup_ZzbEWq4UWD-o5bDabdiXJ1rxE9L93a2Mv7w3Mj2EYhC4JviMYy_u8DJeohPMjNCac0ZgyLI_RGBPJY8lSdYrOAD4wFoIoMUIjKrBiOB2j10Vd943fOOi82djaGV1F9nvbWgDnm8iX0Wq6ilmkm-JPJUF1bm0biFwTga7cl25_onW1A7q-9i2co5NSV2Avhj9B7_PHt9lzvHx5Wsymy9gwjruYCpozygsmioQQgplRmFlDdEq1pUoqUShjVZEmUuBcc8OU1FYXhihelpayCbrZ525b_9lb6LLagbFVqGJ9D5lMqVASpwG83YOm9QCtLbNt6-pQOyM42y2YPcz_Fwzw1ZDa57UtDugwWfCvB19DGKtsdWMcHLBESiZoyn4BgX522Q</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>YAMADA, K</creator><creator>TANAKA, T</creator><creator>MORI, M</creator><creator>TSUBURA, A</creator><creator>MORII, S</creator><creator>TSUBONE, M</creator><creator>ANDO, C</creator><creator>HILGERS, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumors</title><author>YAMADA, K ; TANAKA, T ; MORI, M ; TSUBURA, A ; MORII, S ; TSUBONE, M ; ANDO, C ; HILGERS, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-252b324d35d611103c803ec1a92ae28785d8ce8d96750ba4c387aeadc184ffe23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, Neoplasm - metabolism</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Mucin-1</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Salivary Gland Neoplasms - immunology</topic><topic>Salivary Gland Neoplasms - metabolism</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Salivary Glands - immunology</topic><topic>Salivary Glands - metabolism</topic><topic>Salivary Glands - pathology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAMADA, K</creatorcontrib><creatorcontrib>TANAKA, T</creatorcontrib><creatorcontrib>MORI, M</creatorcontrib><creatorcontrib>TSUBURA, A</creatorcontrib><creatorcontrib>MORII, S</creatorcontrib><creatorcontrib>TSUBONE, M</creatorcontrib><creatorcontrib>ANDO, C</creatorcontrib><creatorcontrib>HILGERS, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMADA, K</au><au>TANAKA, T</au><au>MORI, M</au><au>TSUBURA, A</au><au>MORII, S</au><au>TSUBONE, M</au><au>ANDO, C</au><au>HILGERS, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumors</atitle><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><date>1989</date><risdate>1989</risdate><volume>415</volume><issue>6</issue><spage>509</spage><epage>521</epage><pages>509-521</pages><issn>0174-7398</issn><eissn>1432-2307</eissn><coden>VAAHDJ</coden><abstract>MAM-3 and MAM-6 antigens of human milk fat globule membrane were detected immunohistochemically in 93 cases of salivary gland tumours as well as in normal glands. The antigens were visualized in 10% formalin-fixed paraffin sections. MAM-3 (MoAbs 115G3, 67D11) antigen was distributed in intercalated and striated duct cells of the normal salivary glands, and in luminal tumour cells and squamous metaplastic cells of pleomorphic adenomas. In pleomorphic adenomas the frequency of positive staining with MoAb 67D11 (54/67; 80.6%) was higher than that with MoAb 115G3 (36/67; 53.7%). MAM-6 (MoAbs 115D8, 115F5) antigen was expressed in luminal and lateral borders of serous acinar cells and ductal of the normal glands, and also in luminal borders of tubulo-ductal and glandular structures of salivary gland tumours. Ductal basal cells were characterized by existence of positive staining for MAM-6 antigen, in adenolymphomas MAM-6 antigen was restricted to the basal tumour cells. Some mucous cells of mucoepidermoid tumours were stained specifically with MoAb 115G3, and epidermoid cells of mucoepidermoid carcinomas manifested MAM-6 antigen staining. Immunohistochemical localization of MAM-6 antigen resembled that of epithelial membrane antigen (EMA) detected with MoAb.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2508309</pmid><doi>10.1007/bf00718644</doi><tpages>13</tpages></addata></record> |
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| ispartof | Virchows Archiv A Pathological Anatomy and Histopathology, 1989, Vol.415 (6), p.509-521 |
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| subjects | Antibodies, Monoclonal - immunology Antigens, Neoplasm - metabolism Biological and medical sciences Humans Immunohistochemistry Medical sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mucin-1 Otorhinolaryngology. Stomatology Salivary Gland Neoplasms - immunology Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - pathology Salivary Glands - immunology Salivary Glands - metabolism Salivary Glands - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumors |
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