Three-dimensional studies of acellular glomerular basement membranes in dense-deposit disease
After digestion removed the cells from glomeruli of frozen kidney tissue, we employed scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) from normal kidneys and from kidneys of patients with dense-deposit disease (DDD). The AGBM showed previously unrecognized...
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| Veröffentlicht in: | Virchows Archiv A Pathological Anatomy and Histopathology 1986, Vol.409 (5), p.595-607 |
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| container_title | Virchows Archiv A Pathological Anatomy and Histopathology |
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| creator | WEIDNER, N LORENTZ, W. B. JR |
| description | After digestion removed the cells from glomeruli of frozen kidney tissue, we employed scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) from normal kidneys and from kidneys of patients with dense-deposit disease (DDD). The AGBM showed previously unrecognized three-dimensional patterns of pathologic changes. When compared to normal controls, the AGBM in DDD appeared "rigid" and thickened. Other pathologic features included coarsely granular or undulating epimembranous surfaces punctuated by single or clustered crater-like deformities. Although epimembranous crater-like deformities have been observed in other glomerulopathies, the combination of "rigid"-appearing AGBM punctuated by crater-like deformities is thus far unique to DDD. |
| doi_str_mv | 10.1007/BF00713427 |
| format | Article |
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B. JR</creator><creatorcontrib>WEIDNER, N ; LORENTZ, W. B. JR</creatorcontrib><description>After digestion removed the cells from glomeruli of frozen kidney tissue, we employed scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) from normal kidneys and from kidneys of patients with dense-deposit disease (DDD). The AGBM showed previously unrecognized three-dimensional patterns of pathologic changes. When compared to normal controls, the AGBM in DDD appeared "rigid" and thickened. Other pathologic features included coarsely granular or undulating epimembranous surfaces punctuated by single or clustered crater-like deformities. Although epimembranous crater-like deformities have been observed in other glomerulopathies, the combination of "rigid"-appearing AGBM punctuated by crater-like deformities is thus far unique to DDD.</description><identifier>ISSN: 0174-7398</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/BF00713427</identifier><identifier>PMID: 3092459</identifier><identifier>CODEN: VAAHDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Basement Membrane - ultrastructure ; Biological and medical sciences ; Child ; Child, Preschool ; Glomerulonephritis ; Glomerulonephritis - pathology ; Humans ; Infant ; Infant, Newborn ; Kidney Glomerulus - ultrastructure ; Medical sciences ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. 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B. JR</creatorcontrib><title>Three-dimensional studies of acellular glomerular basement membranes in dense-deposit disease</title><title>Virchows Archiv A Pathological Anatomy and Histopathology</title><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><description>After digestion removed the cells from glomeruli of frozen kidney tissue, we employed scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) from normal kidneys and from kidneys of patients with dense-deposit disease (DDD). The AGBM showed previously unrecognized three-dimensional patterns of pathologic changes. When compared to normal controls, the AGBM in DDD appeared "rigid" and thickened. Other pathologic features included coarsely granular or undulating epimembranous surfaces punctuated by single or clustered crater-like deformities. Although epimembranous crater-like deformities have been observed in other glomerulopathies, the combination of "rigid"-appearing AGBM punctuated by crater-like deformities is thus far unique to DDD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Basement Membrane - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><issn>0174-7398</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo67p68S70IB6Eaj6b9KiLq8KCl_UoJU0mGunHmrQH_3ujW9bLzMD85vHmIXRO8A3BWN7er1IljFN5gOaEM5pThuUhmmMieS5ZqY7RSYyfGAtBlJihGcMl5aKco7fNRwDIrW-hi77vdJPFYbQeYta7TBtomrHRIXtv-hbC31jrCIkeshbaOuguob7LbLpPOrDtox8y6yMk7BQdOd1EOJv6Ar2uHjbLp3z98vi8vFvnhtJiyAvDCcFc6boQpWWCcYu1xE5rI11Zg6AKnGCFUZAeBctLLpwoaqiBWaMcW6Crne429F8jxKFqffz1ntz1Y6ykxFSUgiTwegea0McYwFXb4FsdviuCq98sq_8sE3wxqY51C3aPTuGl_eW019HoxqUsjI97TCrFuGLsByAPfJ4</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>WEIDNER, N</creator><creator>LORENTZ, W. B. 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JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-6c411048ab659d3534d0a70faac7f9be528ef536c8e007ed4945f56bebe3dc8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Basement Membrane - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Glomerulonephritis</topic><topic>Glomerulonephritis - pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Kidney Glomerulus - ultrastructure</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEIDNER, N</creatorcontrib><creatorcontrib>LORENTZ, W. B. JR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEIDNER, N</au><au>LORENTZ, W. B. JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-dimensional studies of acellular glomerular basement membranes in dense-deposit disease</atitle><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><date>1986</date><risdate>1986</risdate><volume>409</volume><issue>5</issue><spage>595</spage><epage>607</epage><pages>595-607</pages><issn>0174-7398</issn><eissn>1432-2307</eissn><coden>VAAHDJ</coden><abstract>After digestion removed the cells from glomeruli of frozen kidney tissue, we employed scanning electron microscopy to examine the acellular glomerular basement membranes (AGBM) from normal kidneys and from kidneys of patients with dense-deposit disease (DDD). The AGBM showed previously unrecognized three-dimensional patterns of pathologic changes. When compared to normal controls, the AGBM in DDD appeared "rigid" and thickened. Other pathologic features included coarsely granular or undulating epimembranous surfaces punctuated by single or clustered crater-like deformities. Although epimembranous crater-like deformities have been observed in other glomerulopathies, the combination of "rigid"-appearing AGBM punctuated by crater-like deformities is thus far unique to DDD.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3092459</pmid><doi>10.1007/BF00713427</doi><tpages>13</tpages></addata></record> |
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| identifier | ISSN: 0174-7398 |
| ispartof | Virchows Archiv A Pathological Anatomy and Histopathology, 1986, Vol.409 (5), p.595-607 |
| issn | 0174-7398 1432-2307 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Basement Membrane - ultrastructure Biological and medical sciences Child Child, Preschool Glomerulonephritis Glomerulonephritis - pathology Humans Infant Infant, Newborn Kidney Glomerulus - ultrastructure Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure |
| title | Three-dimensional studies of acellular glomerular basement membranes in dense-deposit disease |
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