Granular cell tumor arising in myelinated peripheral nerves: light and electron microscopy and immunoperoxidase study
The histologic, immunohistochemical and ultrastructural characteristics of two granular cell tumors arising from the right recurrent laryngeal and left facial nerves are described. S-100 protein was detected both in the nuclei and cytoplasm of the granular cells using the peroxidase-anti-peroxidase...
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| Veröffentlicht in: | Virchows Archiv A Pathological Anatomy and Histopathology 1983-01, Vol.402 (2), p.175-183 |
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| container_end_page | 183 |
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| container_issue | 2 |
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| container_title | Virchows Archiv A Pathological Anatomy and Histopathology |
| container_volume | 402 |
| creator | BEDETTI, C. D MARTINEZ, A. J BECKFORD, N. S MAY, M |
| description | The histologic, immunohistochemical and ultrastructural characteristics of two granular cell tumors arising from the right recurrent laryngeal and left facial nerves are described. S-100 protein was detected both in the nuclei and cytoplasm of the granular cells using the peroxidase-anti-peroxidase method. The ultrastructural findings in both cases support a Schwann cell derivation of the granular cells. It is suggested that the granularity of cells of granular cell tumor may represent a lysosomal disorder affecting most frequently neoplastic and nonneoplastic Schwann cells and occasionally other cells. |
| doi_str_mv | 10.1007/BF00695059 |
| format | Article |
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It is suggested that the granularity of cells of granular cell tumor may represent a lysosomal disorder affecting most frequently neoplastic and nonneoplastic Schwann cells and occasionally other cells.</description><identifier>ISSN: 0340-1227</identifier><identifier>ISSN: 0174-7398</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/BF00695059</identifier><identifier>PMID: 6320526</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Child ; Facial Nerve ; Female ; Humans ; Immunoenzyme Techniques ; Laryngeal Nerves ; Medical sciences ; Microscopy, Electron ; Middle Aged ; Neoplasms, Muscle Tissue - analysis ; Neoplasms, Muscle Tissue - ultrastructure ; Nerve Fibers, Myelinated - pathology ; Neurology ; Peripheral Nervous System Neoplasms - analysis ; Peripheral Nervous System Neoplasms - ultrastructure ; S100 Proteins - analysis ; Schwann Cells - ultrastructure ; Tumors of the nervous system. 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It is suggested that the granularity of cells of granular cell tumor may represent a lysosomal disorder affecting most frequently neoplastic and nonneoplastic Schwann cells and occasionally other cells.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Facial Nerve</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Laryngeal Nerves</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Neoplasms, Muscle Tissue - analysis</subject><subject>Neoplasms, Muscle Tissue - ultrastructure</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neurology</subject><subject>Peripheral Nervous System Neoplasms - analysis</subject><subject>Peripheral Nervous System Neoplasms - ultrastructure</subject><subject>S100 Proteins - analysis</subject><subject>Schwann Cells - ultrastructure</subject><subject>Tumors of the nervous system. 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Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BEDETTI, C. D</creatorcontrib><creatorcontrib>MARTINEZ, A. J</creatorcontrib><creatorcontrib>BECKFORD, N. S</creatorcontrib><creatorcontrib>MAY, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BEDETTI, C. D</au><au>MARTINEZ, A. J</au><au>BECKFORD, N. S</au><au>MAY, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granular cell tumor arising in myelinated peripheral nerves: light and electron microscopy and immunoperoxidase study</atitle><jtitle>Virchows Archiv A Pathological Anatomy and Histopathology</jtitle><addtitle>Virchows Arch A Pathol Anat Histopathol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>402</volume><issue>2</issue><spage>175</spage><epage>183</epage><pages>175-183</pages><issn>0340-1227</issn><issn>0174-7398</issn><eissn>1432-2307</eissn><abstract>The histologic, immunohistochemical and ultrastructural characteristics of two granular cell tumors arising from the right recurrent laryngeal and left facial nerves are described. S-100 protein was detected both in the nuclei and cytoplasm of the granular cells using the peroxidase-anti-peroxidase method. The ultrastructural findings in both cases support a Schwann cell derivation of the granular cells. It is suggested that the granularity of cells of granular cell tumor may represent a lysosomal disorder affecting most frequently neoplastic and nonneoplastic Schwann cells and occasionally other cells.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6320526</pmid><doi>10.1007/BF00695059</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0340-1227 |
| ispartof | Virchows Archiv A Pathological Anatomy and Histopathology, 1983-01, Vol.402 (2), p.175-183 |
| issn | 0340-1227 0174-7398 1432-2307 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00695059 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Biological and medical sciences Child Facial Nerve Female Humans Immunoenzyme Techniques Laryngeal Nerves Medical sciences Microscopy, Electron Middle Aged Neoplasms, Muscle Tissue - analysis Neoplasms, Muscle Tissue - ultrastructure Nerve Fibers, Myelinated - pathology Neurology Peripheral Nervous System Neoplasms - analysis Peripheral Nervous System Neoplasms - ultrastructure S100 Proteins - analysis Schwann Cells - ultrastructure Tumors of the nervous system. Phacomatoses |
| title | Granular cell tumor arising in myelinated peripheral nerves: light and electron microscopy and immunoperoxidase study |
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