The toxin kainic acid: a study of avian nerve and glial cell response utilizing tritiated kainic acid and electron microscopic autoradiography

Three questions are asked regarding the toxin kainic acid (KA). Does it destroy specific glial cells as well as neurons? Does KA gain access to the cytoplasm in intact cells and to which organelles does it bind? Intracerebral injections of tritiated KA into the pigeon (Columba livia) paleostriatal c...

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Veröffentlicht in:	Acta neuropathologica 1988-01, Vol.76 (2), p.185-203
Hauptverfasser:	RIEKE, G. K, SAMPSON, H. W, SCARFE, A. D, BOWERS, D. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Brain - drug effects Brain - metabolism Brain - ultrastructure Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Nucleus - ultrastructure Columbidae Cytoplasm - drug effects Cytoplasm - metabolism Cytoplasm - ultrastructure Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Kainic Acid - pharmacokinetics Kainic Acid - toxicity Microscopy, Electron Neuroglia - ultrastructure Neurons - drug effects Neurons - metabolism Neurons - ultrastructure Oligodendroglia - drug effects Oligodendroglia - metabolism Oligodendroglia - ultrastructure Vertebrates: nervous system and sense organs
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