Alternating chemotherapy in advanced gastric cancer : a phase II study

A phase II study with an alternating chemotherapeutic scheme, in advanced gastric cancer was conducted. Twenty-two patients were treated with cisplatin and mitomycin C on day 1 and BCNU and doxorubicin on day 28. Tegafur p.o. was given daily from the start to the end of chemotherapy. This scheme was...

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Veröffentlicht in:Cancer chemotherapy and pharmacology 1991-01, Vol.28 (4), p.313-314
Hauptverfasser: FELIU, J, GARCIA GIRON, C, GONZALEZ-BARON, M, BERROCAL, A, BARON-SAURA, J. M
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Sprache:eng
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Zusammenfassung:A phase II study with an alternating chemotherapeutic scheme, in advanced gastric cancer was conducted. Twenty-two patients were treated with cisplatin and mitomycin C on day 1 and BCNU and doxorubicin on day 28. Tegafur p.o. was given daily from the start to the end of chemotherapy. This scheme was repeated every four weeks. Response rate was 25% (2 complete and 3 partial). However, remissions were short lived, and median survival for the entire group was 7 months. Haematological and gastrointestinal toxicities were severe. In conclusion, the low response rate and the high toxicity of this regimen preclude its use for the treatment of gastric cancer.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00685542