Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells
In the present study we assessed the effect of combined treatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and tamoxifen (TAM) on the growth of estrogen-responsive (MCF-7) and estrogen-dependent (ZR-75-1) human breast cancer cells. Both basal and 17 beta-estradiol (17 beta-E2)-stimulated growth...
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| Veröffentlicht in: | Breast cancer research and treatment 1994-02, Vol.29 (2), p.161-168 |
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| container_title | Breast cancer research and treatment |
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| creator | VINK-VAN WIJNGAARDEN, T POLS, H. A. P BUURMAN, C. J BIRKENHÄGER, J. C VAN LEEUWEN, J. P. T. M |
| description | In the present study we assessed the effect of combined treatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and tamoxifen (TAM) on the growth of estrogen-responsive (MCF-7) and estrogen-dependent (ZR-75-1) human breast cancer cells. Both basal and 17 beta-estradiol (17 beta-E2)-stimulated growth were studied. 1,25-(OH)2D3 (10(-10)-10(-7) M) time- and dose-dependently inhibited basal growth of MCF-7 cells, with growth arrest at 10(-7) M. Also, 17 beta-E2-stimulated growth of MCF-7 and ZR-75-1 cells was inhibited by 1,25(OH)2D3 in a time- and dose-dependent manner. TAM inhibited 17 beta-E2-stimulated growth of both cell lines and at high concentration (10(-6) M) it also inhibited basal growth of MCF-7 cells. 10(-6) M TAM together with 1,25-(OH)2D3 resulted n a further inhibition of basal (MCF-7 cells) as well as 17 beta-E2-stimulated proliferation (MCF-7 and ZR-75-1 cells) compared to the inhibition by these agents alone. TAM in combination with 10(-7) M 1,25-(OH)2D3 resulted in growth arrest of 17 beta-E2-stimulated growth of MCF-7 cells. The inhibition of basal and 17 beta-E2-stimulated growth of MCF-7 cells was additive at early time points (4 days), but less than additive at later time points (8-10 days). It was demonstrated that with co-treatment of MCF-7 cells an equipotent inhibition of basal growth could be reached with lower concentrations of 1,25-(OH)2D3, compared to treatment with 1,25-(OH)2D3 alone. |
| doi_str_mv | 10.1007/BF00665677 |
| format | Article |
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A. P ; BUURMAN, C. J ; BIRKENHÄGER, J. C ; VAN LEEUWEN, J. P. T. M</creator><creatorcontrib>VINK-VAN WIJNGAARDEN, T ; POLS, H. A. P ; BUURMAN, C. J ; BIRKENHÄGER, J. C ; VAN LEEUWEN, J. P. T. M</creatorcontrib><description>In the present study we assessed the effect of combined treatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and tamoxifen (TAM) on the growth of estrogen-responsive (MCF-7) and estrogen-dependent (ZR-75-1) human breast cancer cells. Both basal and 17 beta-estradiol (17 beta-E2)-stimulated growth were studied. 1,25-(OH)2D3 (10(-10)-10(-7) M) time- and dose-dependently inhibited basal growth of MCF-7 cells, with growth arrest at 10(-7) M. Also, 17 beta-E2-stimulated growth of MCF-7 and ZR-75-1 cells was inhibited by 1,25(OH)2D3 in a time- and dose-dependent manner. TAM inhibited 17 beta-E2-stimulated growth of both cell lines and at high concentration (10(-6) M) it also inhibited basal growth of MCF-7 cells. 10(-6) M TAM together with 1,25-(OH)2D3 resulted n a further inhibition of basal (MCF-7 cells) as well as 17 beta-E2-stimulated proliferation (MCF-7 and ZR-75-1 cells) compared to the inhibition by these agents alone. TAM in combination with 10(-7) M 1,25-(OH)2D3 resulted in growth arrest of 17 beta-E2-stimulated growth of MCF-7 cells. The inhibition of basal and 17 beta-E2-stimulated growth of MCF-7 cells was additive at early time points (4 days), but less than additive at later time points (8-10 days). It was demonstrated that with co-treatment of MCF-7 cells an equipotent inhibition of basal growth could be reached with lower concentrations of 1,25-(OH)2D3, compared to treatment with 1,25-(OH)2D3 alone.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/BF00665677</identifier><identifier>PMID: 8012034</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Breast Neoplasms ; Calcitriol - toxicity ; Cell Division - drug effects ; Cell Line ; Chemotherapy ; Dose-Response Relationship, Drug ; Drug Synergism ; Estradiol - pharmacology ; Female ; Humans ; Kinetics ; Medical sciences ; Pharmacology. Drug treatments ; Tamoxifen - toxicity ; Time Factors ; Tumor Cells, Cultured</subject><ispartof>Breast cancer research and treatment, 1994-02, Vol.29 (2), p.161-168</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2627-141c9e045ef5603a2d6c7175bbe7a4f2019c6cac0fd01e0c2e6f646829ad00eb3</citedby><cites>FETCH-LOGICAL-c2627-141c9e045ef5603a2d6c7175bbe7a4f2019c6cac0fd01e0c2e6f646829ad00eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3975556$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8012034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VINK-VAN WIJNGAARDEN, T</creatorcontrib><creatorcontrib>POLS, H. A. P</creatorcontrib><creatorcontrib>BUURMAN, C. J</creatorcontrib><creatorcontrib>BIRKENHÄGER, J. C</creatorcontrib><creatorcontrib>VAN LEEUWEN, J. P. T. M</creatorcontrib><title>Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>In the present study we assessed the effect of combined treatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and tamoxifen (TAM) on the growth of estrogen-responsive (MCF-7) and estrogen-dependent (ZR-75-1) human breast cancer cells. Both basal and 17 beta-estradiol (17 beta-E2)-stimulated growth were studied. 1,25-(OH)2D3 (10(-10)-10(-7) M) time- and dose-dependently inhibited basal growth of MCF-7 cells, with growth arrest at 10(-7) M. Also, 17 beta-E2-stimulated growth of MCF-7 and ZR-75-1 cells was inhibited by 1,25(OH)2D3 in a time- and dose-dependent manner. TAM inhibited 17 beta-E2-stimulated growth of both cell lines and at high concentration (10(-6) M) it also inhibited basal growth of MCF-7 cells. 10(-6) M TAM together with 1,25-(OH)2D3 resulted n a further inhibition of basal (MCF-7 cells) as well as 17 beta-E2-stimulated proliferation (MCF-7 and ZR-75-1 cells) compared to the inhibition by these agents alone. TAM in combination with 10(-7) M 1,25-(OH)2D3 resulted in growth arrest of 17 beta-E2-stimulated growth of MCF-7 cells. The inhibition of basal and 17 beta-E2-stimulated growth of MCF-7 cells was additive at early time points (4 days), but less than additive at later time points (8-10 days). It was demonstrated that with co-treatment of MCF-7 cells an equipotent inhibition of basal growth could be reached with lower concentrations of 1,25-(OH)2D3, compared to treatment with 1,25-(OH)2D3 alone.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms</subject><subject>Calcitriol - toxicity</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Chemotherapy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Tamoxifen - toxicity</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUh4Moc04v3oUcPInRl7RJ1qNWp8JEEL14KWn6YitrO5LObf-9nY55ejx-3-_B-wg55XDFAfT17QRAKam03iNDLnXEtOB6nwyBK83UGNQhOQrhCwASDcmADMbABUTxkCzTts6rBguKzqHtAm0d5ZdCsqIq14VvV-vvqjN11dC7iJqmoP3SriqHDW0b2pVIP3277MpN7zmdMP0LfbwyLRmn5aI2Dc09mtBRaxqLnlqczcIxOXBmFvBkO0fkfXL_lj6y6cvDU3ozZVYooRmPuU0QYolOKoiMKJTVXMs8R21iJ4AnVlljwRXAEaxA5VSsxiIxBQDm0Yhc_N21vg3Bo8vmvqqNX2ccso287F9eD5_9wfNFXmOxQ7e2-vx8m5tgzcz5_qEq7LAo0VJKFf0Ato50Ng</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>VINK-VAN WIJNGAARDEN, T</creator><creator>POLS, H. A. P</creator><creator>BUURMAN, C. J</creator><creator>BIRKENHÄGER, J. C</creator><creator>VAN LEEUWEN, J. P. T. M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199402</creationdate><title>Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells</title><author>VINK-VAN WIJNGAARDEN, T ; POLS, H. A. P ; BUURMAN, C. J ; BIRKENHÄGER, J. C ; VAN LEEUWEN, J. P. T. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2627-141c9e045ef5603a2d6c7175bbe7a4f2019c6cac0fd01e0c2e6f646829ad00eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms</topic><topic>Calcitriol - toxicity</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Chemotherapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Tamoxifen - toxicity</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VINK-VAN WIJNGAARDEN, T</creatorcontrib><creatorcontrib>POLS, H. A. P</creatorcontrib><creatorcontrib>BUURMAN, C. J</creatorcontrib><creatorcontrib>BIRKENHÄGER, J. C</creatorcontrib><creatorcontrib>VAN LEEUWEN, J. P. T. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VINK-VAN WIJNGAARDEN, T</au><au>POLS, H. A. P</au><au>BUURMAN, C. J</au><au>BIRKENHÄGER, J. C</au><au>VAN LEEUWEN, J. P. T. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>1994-02</date><risdate>1994</risdate><volume>29</volume><issue>2</issue><spage>161</spage><epage>168</epage><pages>161-168</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>In the present study we assessed the effect of combined treatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and tamoxifen (TAM) on the growth of estrogen-responsive (MCF-7) and estrogen-dependent (ZR-75-1) human breast cancer cells. Both basal and 17 beta-estradiol (17 beta-E2)-stimulated growth were studied. 1,25-(OH)2D3 (10(-10)-10(-7) M) time- and dose-dependently inhibited basal growth of MCF-7 cells, with growth arrest at 10(-7) M. Also, 17 beta-E2-stimulated growth of MCF-7 and ZR-75-1 cells was inhibited by 1,25(OH)2D3 in a time- and dose-dependent manner. TAM inhibited 17 beta-E2-stimulated growth of both cell lines and at high concentration (10(-6) M) it also inhibited basal growth of MCF-7 cells. 10(-6) M TAM together with 1,25-(OH)2D3 resulted n a further inhibition of basal (MCF-7 cells) as well as 17 beta-E2-stimulated proliferation (MCF-7 and ZR-75-1 cells) compared to the inhibition by these agents alone. TAM in combination with 10(-7) M 1,25-(OH)2D3 resulted in growth arrest of 17 beta-E2-stimulated growth of MCF-7 cells. The inhibition of basal and 17 beta-E2-stimulated growth of MCF-7 cells was additive at early time points (4 days), but less than additive at later time points (8-10 days). It was demonstrated that with co-treatment of MCF-7 cells an equipotent inhibition of basal growth could be reached with lower concentrations of 1,25-(OH)2D3, compared to treatment with 1,25-(OH)2D3 alone.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>8012034</pmid><doi>10.1007/BF00665677</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Breast cancer research and treatment, 1994-02, Vol.29 (2), p.161-168 |
| issn | 0167-6806 1573-7217 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00665677 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Antineoplastic agents Biological and medical sciences Breast Neoplasms Calcitriol - toxicity Cell Division - drug effects Cell Line Chemotherapy Dose-Response Relationship, Drug Drug Synergism Estradiol - pharmacology Female Humans Kinetics Medical sciences Pharmacology. Drug treatments Tamoxifen - toxicity Time Factors Tumor Cells, Cultured |
| title | Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells |
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