The effect of sympathomimetic drugs on bone capillaries
Mineral transport to bone is dependent on an adequate blood supply. Thus, the role of vasoactive agents merits orthopaedic interest. This paper outlines the morphology of osteons and capillaries in cortical bone and discusses the possible morphological effects of systemic phenylephrine on mice tibia...
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| Veröffentlicht in: | Archives of Orthopaedic and Traumatic Surgery 1986, Vol.105 (1), p.62-65 |
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| container_end_page | 65 |
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| container_title | Archives of Orthopaedic and Traumatic Surgery |
| container_volume | 105 |
| creator | Döhler, J R Robertson, S Hughes, S P |
| description | Mineral transport to bone is dependent on an adequate blood supply. Thus, the role of vasoactive agents merits orthopaedic interest. This paper outlines the morphology of osteons and capillaries in cortical bone and discusses the possible morphological effects of systemic phenylephrine on mice tibiae. The frequency of dilated capillaries on histological serial sections did not significantly change. Hence, a postcapillary mechanism is likely to explain previous EM findings: i.e., an adrenaline-induced increase of the lumen diameter and perivascular cell edema. |
| doi_str_mv | 10.1007/BF00625663 |
| format | Article |
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Thus, the role of vasoactive agents merits orthopaedic interest. This paper outlines the morphology of osteons and capillaries in cortical bone and discusses the possible morphological effects of systemic phenylephrine on mice tibiae. The frequency of dilated capillaries on histological serial sections did not significantly change. Hence, a postcapillary mechanism is likely to explain previous EM findings: i.e., an adrenaline-induced increase of the lumen diameter and perivascular cell edema.</description><identifier>ISSN: 0344-8444</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/BF00625663</identifier><identifier>PMID: 2423055</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Bone and Bones - blood supply ; Bone and Bones - drug effects ; Capillaries - drug effects ; Female ; Haversian System - blood supply ; Haversian System - drug effects ; Mice ; Microscopy, Electron, Scanning ; Microtomy ; Phenylephrine - pharmacology ; Staining and Labeling ; Sympathomimetics - pharmacology ; Tibia - blood supply</subject><ispartof>Archives of Orthopaedic and Traumatic Surgery, 1986, Vol.105 (1), p.62-65</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-7f5daf382ca133b09db41ff898d430cfb5ee3415e7adfbfee04472938e35d4c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2423055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Döhler, J R</creatorcontrib><creatorcontrib>Robertson, S</creatorcontrib><creatorcontrib>Hughes, S P</creatorcontrib><title>The effect of sympathomimetic drugs on bone capillaries</title><title>Archives of Orthopaedic and Traumatic Surgery</title><addtitle>Arch Orthop Trauma Surg</addtitle><description>Mineral transport to bone is dependent on an adequate blood supply. Thus, the role of vasoactive agents merits orthopaedic interest. This paper outlines the morphology of osteons and capillaries in cortical bone and discusses the possible morphological effects of systemic phenylephrine on mice tibiae. The frequency of dilated capillaries on histological serial sections did not significantly change. Hence, a postcapillary mechanism is likely to explain previous EM findings: i.e., an adrenaline-induced increase of the lumen diameter and perivascular cell edema.</description><subject>Animals</subject><subject>Bone and Bones - blood supply</subject><subject>Bone and Bones - drug effects</subject><subject>Capillaries - drug effects</subject><subject>Female</subject><subject>Haversian System - blood supply</subject><subject>Haversian System - drug effects</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microtomy</subject><subject>Phenylephrine - pharmacology</subject><subject>Staining and Labeling</subject><subject>Sympathomimetics - pharmacology</subject><subject>Tibia - blood supply</subject><issn>0344-8444</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0FLwzAYhoMos8xdvAs5C9Uk35cmPepwKgy8zHNJky-u0q6l6Q7790429L28l4cHHsZupXiQQpjH55UQhdJFARcskwiYQymLS5YJQMwtIl6zRUrf4jiwRqtyxmYKFQitM2Y2W-IUI_mJ95GnQze4adt3TUdT43kY91-J9zte9zvi3g1N27qxoXTDrqJrEy3OP2efq5fN8i1ff7y-L5_WuVcop9xEHVwEq7yTALUoQ40yRlvagCB8rDURoNRkXIh1JBKIRpVgCXRAb2DO7k9eP_YpjRSrYWw6Nx4qKarf_uq__wjfneBhX3cU_tBzLfwAEplUlA</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Döhler, J R</creator><creator>Robertson, S</creator><creator>Hughes, S P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1986</creationdate><title>The effect of sympathomimetic drugs on bone capillaries</title><author>Döhler, J R ; Robertson, S ; Hughes, S P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-7f5daf382ca133b09db41ff898d430cfb5ee3415e7adfbfee04472938e35d4c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Bone and Bones - blood supply</topic><topic>Bone and Bones - drug effects</topic><topic>Capillaries - drug effects</topic><topic>Female</topic><topic>Haversian System - blood supply</topic><topic>Haversian System - drug effects</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microtomy</topic><topic>Phenylephrine - pharmacology</topic><topic>Staining and Labeling</topic><topic>Sympathomimetics - pharmacology</topic><topic>Tibia - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Döhler, J R</creatorcontrib><creatorcontrib>Robertson, S</creatorcontrib><creatorcontrib>Hughes, S P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Archives of Orthopaedic and Traumatic Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Döhler, J R</au><au>Robertson, S</au><au>Hughes, S P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of sympathomimetic drugs on bone capillaries</atitle><jtitle>Archives of Orthopaedic and Traumatic Surgery</jtitle><addtitle>Arch Orthop Trauma Surg</addtitle><date>1986</date><risdate>1986</risdate><volume>105</volume><issue>1</issue><spage>62</spage><epage>65</epage><pages>62-65</pages><issn>0344-8444</issn><eissn>1434-3916</eissn><abstract>Mineral transport to bone is dependent on an adequate blood supply. Thus, the role of vasoactive agents merits orthopaedic interest. This paper outlines the morphology of osteons and capillaries in cortical bone and discusses the possible morphological effects of systemic phenylephrine on mice tibiae. The frequency of dilated capillaries on histological serial sections did not significantly change. Hence, a postcapillary mechanism is likely to explain previous EM findings: i.e., an adrenaline-induced increase of the lumen diameter and perivascular cell edema.</abstract><cop>Germany</cop><pmid>2423055</pmid><doi>10.1007/BF00625663</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-8444 |
| ispartof | Archives of Orthopaedic and Traumatic Surgery, 1986, Vol.105 (1), p.62-65 |
| issn | 0344-8444 1434-3916 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00625663 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Bone and Bones - blood supply Bone and Bones - drug effects Capillaries - drug effects Female Haversian System - blood supply Haversian System - drug effects Mice Microscopy, Electron, Scanning Microtomy Phenylephrine - pharmacology Staining and Labeling Sympathomimetics - pharmacology Tibia - blood supply |
| title | The effect of sympathomimetic drugs on bone capillaries |
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