Renin-like (angiotensinogenase) activity in human eccrine sweat
The presence of renin or renin-like activity (RLA) was demonstrated in human eccrine sweat incubated with purified sheep angiotensinogen, using rat bioassay and angiotensin I radioimmunoassay. Following cholinergic stimulation, sweat RLA was found to range between 0 (unmeasurable) and 266 ng/ml.h, i...
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| Veröffentlicht in: | Pflügers Archiv 1978-10, Vol.377 (1), p.65-67 |
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| container_title | Pflügers Archiv |
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| creator | Dahlheim, H Emrich, H M |
| description | The presence of renin or renin-like activity (RLA) was demonstrated in human eccrine sweat incubated with purified sheep angiotensinogen, using rat bioassay and angiotensin I radioimmunoassay. Following cholinergic stimulation, sweat RLA was found to range between 0 (unmeasurable) and 266 ng/ml.h, i.e. RLA-values of sweat can be about 10 times higher than those of plasma. Therefore, renin synthesis in sweat glands could be assumed. RLA following activation of beta-adrenergic receptors by the administration of isoprenaline (Aludrin) did not exceed the mean values obtained by cholinergic activation. After beta-adrenergic receptor blockade by propranolol (Dociton), RLA became unmeasurably low. Higher RLA-values were found after local injection of dibutyryl-c-AMP (90--210 ng/ml.h). The results indicate a beta-adrenergic regulation of RLA-release in human sweat glands. Human sweat glands appear to be useful for studying extrarenal renin release. |
| doi_str_mv | 10.1007/BF00584375 |
| format | Article |
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Following cholinergic stimulation, sweat RLA was found to range between 0 (unmeasurable) and 266 ng/ml.h, i.e. RLA-values of sweat can be about 10 times higher than those of plasma. Therefore, renin synthesis in sweat glands could be assumed. RLA following activation of beta-adrenergic receptors by the administration of isoprenaline (Aludrin) did not exceed the mean values obtained by cholinergic activation. After beta-adrenergic receptor blockade by propranolol (Dociton), RLA became unmeasurably low. Higher RLA-values were found after local injection of dibutyryl-c-AMP (90--210 ng/ml.h). The results indicate a beta-adrenergic regulation of RLA-release in human sweat glands. 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Following cholinergic stimulation, sweat RLA was found to range between 0 (unmeasurable) and 266 ng/ml.h, i.e. RLA-values of sweat can be about 10 times higher than those of plasma. Therefore, renin synthesis in sweat glands could be assumed. RLA following activation of beta-adrenergic receptors by the administration of isoprenaline (Aludrin) did not exceed the mean values obtained by cholinergic activation. After beta-adrenergic receptor blockade by propranolol (Dociton), RLA became unmeasurably low. Higher RLA-values were found after local injection of dibutyryl-c-AMP (90--210 ng/ml.h). The results indicate a beta-adrenergic regulation of RLA-release in human sweat glands. Human sweat glands appear to be useful for studying extrarenal renin release.</description><subject>Animals</subject><subject>Biological Assay</subject><subject>Blood Pressure - drug effects</subject><subject>Carbachol - pharmacology</subject><subject>Endopeptidases - metabolism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Rats</subject><subject>Renin - metabolism</subject><subject>Sweat - drug effects</subject><subject>Sweat - enzymology</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYP4Gqsb1y6yVGH05jHJZFW0WBUKguh6yGRuarSTlslU6b-3MqKrs_nOgfMRcsrgigHo69spQFFKoYsdkjEpeM6BiV2SAQiWK63KQ3KU0jsAcFnyA7LPmdQFy8j4GWOI-SJ8ID23cR6WPcYU4nKO0Sa8oNb14TP0GxoifVu3NlJ0rgsRafpC2x-TPW8XCU9-c0Rep3cvk4d89nT_OLmZ5Y4X0OeeK69LBcYxw7UGXjuvjEblGYcCVeM1qwulvFHGSYYa6m2laYwRUspSiRG5HHZdt0ypQ1-tutDablMxqH4cVP8OtvDZAK_WdYvNHzqcFt8zbFTs</recordid><startdate>197810</startdate><enddate>197810</enddate><creator>Dahlheim, H</creator><creator>Emrich, H M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197810</creationdate><title>Renin-like (angiotensinogenase) activity in human eccrine sweat</title><author>Dahlheim, H ; Emrich, H M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-f26f78609c1927702bcf697e6f1205e6df71b566f969c41e70bf26dd993444863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Biological Assay</topic><topic>Blood Pressure - drug effects</topic><topic>Carbachol - pharmacology</topic><topic>Endopeptidases - metabolism</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Rats</topic><topic>Renin - metabolism</topic><topic>Sweat - drug effects</topic><topic>Sweat - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dahlheim, H</creatorcontrib><creatorcontrib>Emrich, H M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pflügers Archiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dahlheim, H</au><au>Emrich, H M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renin-like (angiotensinogenase) activity in human eccrine sweat</atitle><jtitle>Pflügers Archiv</jtitle><addtitle>Pflugers Arch</addtitle><date>1978-10</date><risdate>1978</risdate><volume>377</volume><issue>1</issue><spage>65</spage><epage>67</epage><pages>65-67</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><abstract>The presence of renin or renin-like activity (RLA) was demonstrated in human eccrine sweat incubated with purified sheep angiotensinogen, using rat bioassay and angiotensin I radioimmunoassay. Following cholinergic stimulation, sweat RLA was found to range between 0 (unmeasurable) and 266 ng/ml.h, i.e. RLA-values of sweat can be about 10 times higher than those of plasma. Therefore, renin synthesis in sweat glands could be assumed. RLA following activation of beta-adrenergic receptors by the administration of isoprenaline (Aludrin) did not exceed the mean values obtained by cholinergic activation. After beta-adrenergic receptor blockade by propranolol (Dociton), RLA became unmeasurably low. Higher RLA-values were found after local injection of dibutyryl-c-AMP (90--210 ng/ml.h). The results indicate a beta-adrenergic regulation of RLA-release in human sweat glands. Human sweat glands appear to be useful for studying extrarenal renin release.</abstract><cop>Germany</cop><pmid>214751</pmid><doi>10.1007/BF00584375</doi><tpages>3</tpages></addata></record> |
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| issn | 0031-6768 1432-2013 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological Assay Blood Pressure - drug effects Carbachol - pharmacology Endopeptidases - metabolism Humans Kinetics Rats Renin - metabolism Sweat - drug effects Sweat - enzymology |
| title | Renin-like (angiotensinogenase) activity in human eccrine sweat |
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